대한한방내과학회지 (The Journal of Internal Korean Medicine)

대한한방내과학회 (The Society of Internal Korean Medicine)
권호 표지

대분청음(大分淸飮)이 Cisplatin으로 유발(誘發) 된 흰쥐의 급성신부전(急性腎不全)에 미치는 영향(影響)

Nephroprotective Effects of Daebuncheong-eum Aqueous Extracts on Cisplatin-induced Acute Renal Failure in Rats

  • 이연경 (대구한의대학교 부속한방병원 신계내과학교실) ;
  • 윤경민 (대구한의대학교 부속한방병원 신계내과학교실) ;
  • 장수영 (대구한의대학교 부속한방병원 신계내과학교실) ;
  • 강석봉 (대구한의대학교 부속한방병원 신계내과학교실)
  • Lee, Yeon-Keong (Dept. of Oriental Internal Medicine Graduate School, Dea-Gu Haany University) ;
  • Yoon, Kyeong-Min (Dept. of Oriental Internal Medicine Graduate School, Dea-Gu Haany University) ;
  • Jang, Su-Yeong (Dept. of Oriental Internal Medicine Graduate School, Dea-Gu Haany University) ;
  • Kang, Seok-Bong (Dept. of Oriental Internal Medicine Graduate School, Dea-Gu Haany University)
  • 발행 : 2009.12.30
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초록

Purpose : This study was to observe the nephroprotective effects of the traditional prescription, Daebuncheong-eum (DBCE). DBCE has generally been used for treating various renal diseases, including renal failure. Methods : Three different dosages of DBCE extract were orally administered once a day for 28 days. At the 23rd day after DBCE extract treatment, cisplatin was also treated. Then, 5 days after cisplatin treatment, all rats (6 groups of 8 rats each) were sacrificed. Changes on the body weight, kidney weight, serum BUN and creatinine levels were observed, along with changes to the kidney MDA and GSH contents. The results were compared with captopril 100mg/kg, from which the effects on cisplatin-induced acute renal failures have already been confirmed. Results : Cisplatin induced ARF are induced by oxidative stress and related lipid peroxidation in the present study. However, these ARFs and inhibition of antioxidant effects induced by cisplatin were dose-dependently reduced by treatment of all three different dosages of DBCE extracts. Conclusion : This study suggests that DBCE extracts show favorable effects on cisplatin-induced rat ARF.

키워드

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