한방병원에 입원한 뇌경색 환자의 기능회복과 관련된 특성에 대한 연구

The Study about Characteristics Affecting Functional Recovery of Stroke Patients Treated in an Oriental Medical Center

  • 김영지 (경희대학교 한의과대학 심계내과학교실) ;
  • 김미영 (경희대학교 한의과대학 심계내과학교실) ;
  • 이승엽 (경희대학교 한의과대학 심계내과학교실) ;
  • 최원우 (경희대학교 한의과대학 심계내과학교실) ;
  • 박주영 (경희대학교 한의과대학 심계내과학교실) ;
  • 권승원 (경희대학교 한의과대학 심계내과학교실) ;
  • 정우상 (경희대학교 한의과대학 심계내과학교실) ;
  • 문상관 (경희대학교 한의과대학 심계내과학교실) ;
  • 조기호 (경희대학교 한의과대학 심계내과학교실) ;
  • 김영석 (경희대학교 한의과대학 심계내과학교실) ;
  • 박성욱 (경희대학교 동서신의학병원 중풍.뇌혈관질환센터) ;
  • 박정미 (경희대학교 동서신의학병원 중풍.뇌혈관질환센터) ;
  • 고창남 (경희대학교 동서신의학병원 중풍.뇌혈관질환센터) ;
  • 배형섭 (경희대학교 동서신의학병원 중풍.뇌혈관질환센터) ;
  • 나병조 (강남경희한방병원 내과학교실)
  • Kim, Young-Jee (Dept. of Cardiovascular & Neurologic Diseases(Stroke center), College of Oriental Medicine, Kyung-Hee University) ;
  • Kim, Mi-Young (Dept. of Cardiovascular & Neurologic Diseases(Stroke center), College of Oriental Medicine, Kyung-Hee University) ;
  • Lee, Seung-Yeop (Dept. of Cardiovascular & Neurologic Diseases(Stroke center), College of Oriental Medicine, Kyung-Hee University) ;
  • Choi, Won-Woo (Dept. of Cardiovascular & Neurologic Diseases(Stroke center), College of Oriental Medicine, Kyung-Hee University) ;
  • Park, Joo-Young (Dept. of Cardiovascular & Neurologic Diseases(Stroke center), College of Oriental Medicine, Kyung-Hee University) ;
  • Kwon, Seung-Won (Dept. of Cardiovascular & Neurologic Diseases(Stroke center), College of Oriental Medicine, Kyung-Hee University) ;
  • Jung, Woo-Sang (Dept. of Cardiovascular & Neurologic Diseases(Stroke center), College of Oriental Medicine, Kyung-Hee University) ;
  • Moon, Sang-Kwan (Dept. of Cardiovascular & Neurologic Diseases(Stroke center), College of Oriental Medicine, Kyung-Hee University) ;
  • Cho, Ki-Ho (Dept. of Cardiovascular & Neurologic Diseases(Stroke center), College of Oriental Medicine, Kyung-Hee University) ;
  • Kim, Young-Suk (Dept. of Cardiovascular & Neurologic Diseases(Stroke center), College of Oriental Medicine, Kyung-Hee University) ;
  • Park, Sung-Wook (Stroke & Neurological Disorders Center, East-West Neo Medical Center, Kyung-Hee University) ;
  • Park, Jung-Mi (Stroke & Neurological Disorders Center, East-West Neo Medical Center, Kyung-Hee University) ;
  • Ko, Chang-Nam (Stroke & Neurological Disorders Center, East-West Neo Medical Center, Kyung-Hee University) ;
  • Bae, Hyung-Sup (Stroke & Neurological Disorders Center, East-West Neo Medical Center, Kyung-Hee University) ;
  • Na, Byong-Jo (Dept. of Internal Medicine, Kang-Nam Kyung-Hee Oriental Medicine Hospital)
  • 발행 : 2009.12.30

초록

Objectives : Stroke is the most common disabling neurological disease of adult life. The treatment and rehabilitation of stroke patients is an important and challenging area in the field of medicine. In Korea, a lot of stroke patients are treated using oriental medicine and there have been reports on their functional recovery. The aim of this study was to prove the therapeutic effect of oriental medicine on ischemic stroke. We also tried to identify characteristics of patients whose functional recovery was prominent and studied whether or not the use of fluids, anticoagulants, antiplatelets and neuroprotective agents increased the functional recovery of patients. Methods : We studied 794 patients within 2 weeks after first attack of ischemic stroke who were admitted to Kyung-Hee Oriental Medical Center from 1999 to 2000. Their maximum admission period was 60 days. Results : Motor power grade, NIHSS and MBI scores of patients improved during hospitalization significantly. Factors affecting functional recovery were admission period, motor power grade, NIHSS and MBI at admission. Age, waist-hip ratio and HDL cholesterol also affected functional recovery of patients. Whether or not fluids, anticoagulants, antiplatelets and neuroprotective agents were administered had nothing to do with functional recovery. Conclusion : Oriental medicine is effective for treatment and rehabilitation of ischemic stroke patients. When we manage stroke, we have to consider some important factors.

키워드

참고문헌

  1. 통계청. 사망원인통계연보. 2009.
  2. 박주영, 임형호. Modified Barthel Index, NIH Stroke Scales, Pulses Profile을 이용한 뇌졸중 환자의 평가. 한방재활의학회지. 1997;7(1):483-520.
  3. 한태륜, 김진호, 김진숙. 뇌졸중 환자의 방사선학적 소견과 기능적 회복에 관한 연구. 대한재활의학회지. 1990;14(2):169-75.
  4. 김진숙, 하정상, 변영주. 급성뇌경색 환자의 기능 회복에 관한 예지적 연구. 대한신경과학회지. 1991;11:281-92.
  5. Kim JS, Yoon SS. Perspectives of stroke in persons living in Seoul, South Korea: a survey of 1000 subjects. Stroke. 1997;28:1165-69. https://doi.org/10.1161/01.STR.28.6.1165
  6. Choi KS, Lee SK, Park HA, Kwon SU, Ahn JS, Kim JS. What stroke patients want to know and what medical professionals think they should know about stroke: Korean perspectives. Patient Educ Couns. 2005;56(1):85-92. https://doi.org/10.1016/j.pec.2003.12.011
  7. 노진환, 최동준, 문상관, 조기호, 김영석, 배형섭 등. 한방병원에 입원한 중풍환자의 기능회복도 평가: MBI와 NIH Stroke Scale 이용. 한방성인병학회지. 1999;5(1):40-9.
  8. Wardlaw J, Dennis M, Lindley R, Sellar R, Warlow C. The validity of a simple clinical classification of acute ischaemic stroke. J Neurol. 1996;243:274-9. https://doi.org/10.1007/BF00868526
  9. Wlodek A, Sarzyn'ska-Dlugosza I, Sandercockc P, Czlonkowska A. Agreement between the clinical Oxfordshire Community Stroke Project classification and CT findings in Poland. European Journal of Neurology. 2004;11:91-6. https://doi.org/10.1046/j.1351-5101.2003.00712.x
  10. 고성규, 고창남, 조기호, 김영석, 배형섭, 이경섭. 뇌졸중환자의 기능평가방법에 대한 연구. 대한한의학회지. 1996;17(1):48-83.
  11. 홍근식. 뇌졸중 임상시험에서 치료결과의 측정 및 효과 판정. J Korean Neurol Assoc. 2006;24(5):411-20.
  12. 윤성상, 부선희, 박기정, 장혜정, 권영대. NIH Stroke Scale을 이용한 초기 뇌졸중 중증도에 대한 후향적 평가의 타당성. J Korean Neurol Assoc. 2006;24(1):14-20.
  13. 고성규, 오희라. 급성기 뇌졸중 환자의 기능회복도에 대한 임상적 고찰: MBI, MAS를 이용하여. 한방성인병학회지. 1997;3(1):206-30.
  14. 최동준, 구본수, 고창남, 조기호, 김영석, 배형섭. 급성기 중풍 환자에 대한 성향정기산의 임상적 효능. 대한한방내과학회지. 2002;23(3):440-6.
  15. Ko CN, Moon SK, Cho KH, Kim YS, Bae HS, Lee KS. Clinical research on the rehabilitation of stroke patients' motor ability. Korean Journal of Oriental Medicine. 2002;3(1):107-19.
  16. 조태성, 손인석, 김철홍, 서정철, 윤현민, 장경전 등. 동씨침을 가미한 치료가 중풍환자의NIH Stroke Scale과 MBI상의 기능 회복에 미치는 영향. 대한침구학회지. 2002;20(5):35-45.
  17. 류재춘, 박인범, 김상우, 김철홍, 서정철, 윤현민 등. 두침이 중풍환자의 단기간 NIHSS와 MBI에 미치는 영향. 한의학연구소 동의한의연. 2002;6:7-18.
  18. Wade DT, Hewer RL. Functional abilities after stroke: measurement, natural history and prognosis. J Neurol Neurosurg Psychiatry. 1987;50:177-82. https://doi.org/10.1136/jnnp.50.2.177
  19. Jonbleod. Prediction of function after stroke: a critical review. Stroke. 1986;7:765-76.
  20. Feibel JH, Springer CJ. Depression and failure to resume social activities after stroke. Arch Phvs Med Rehabil. 1982;63:276-7.
  21. Denti L, Agosti M, Franceschini M. Outcome predictors of rehabilitation for first stroke in the elderly. Eur J Phys Rehabil Med. 2008;44:3-11.
  22. Nakayama H, Jorgensen HS, Raaschou HO, Olsen TS. The influence of age on stroke outcome: The Copenhagen Stroke Study. Stroke. 1994;25(4):808-13. https://doi.org/10.1161/01.STR.25.4.808
  23. Falconer JA, Naughton BJ, Strasser DC, Sinacore JM. Stroke inpatient rehabilitation: a comparison across age groups. J Am Geriatr Soc. 1994;42(1):39-44.
  24. Tilling K, Sterne J, Rudd A, Glass T, Wityk R, Wolfe C. A new method for predicting recovery after stroke. Stroke. 2001:32:2867-73. https://doi.org/10.1161/hs1201.099413
  25. Bagg S, Pombo AP, Hopman W. Effect of age on functional outcomes after stroke rehabilitation. Stroke. 2002;33:179-85. https://doi.org/10.1161/hs0102.101224
  26. Larsson B, Svardsudd K, Welin L, Wilhhelmsen L, Biorntorp P, Tibblin G. Abdominal adipose tissue distribution, obesity and risk of cardiovascular disease and death: a 13 year follow up of participants in the study of men born in 1913. Br Med J. 1984;288:1401-4. https://doi.org/10.1136/bmj.288.6428.1401
  27. Choi SH, Kim DJ, Lee KE, Kim YM, Song YD, Kim HD, Ahn CW, Cha BS, Huh KB, Lee HC. Cut-off value of waist circumference for metabolic syndrome patients in Korea adult population. Journal of Korean Society for the Study of Obesity. 2004:13(1):53-60.
  28. Jia WP, Xiang KS, Chen L, Lu JX, Wu YM. Epidemiology study on obesity and its comorbidities in urban Chinese older than 20years of age in Shanghai, China. Obesity Review. 2002;3:157-65. https://doi.org/10.1046/j.1467-789X.2002.00071.x
  29. Jung WS, Kwon DI, Bae JM, Moon SK, Kim YS, Cho KH. Correlation among obesity factor in stroke in Korea. Journal of Korean Oriental Med. 2003;24(4):6-10.
  30. Bu SA, Ko SG, Jung YS, Park KH. The case-control study on the risk factors of stroke in Korean adults. Korean Journal of Oriental Int Med. 2001:22(3):423-30.
  31. Hankey GJ. Potential new risk factor for ischemic stroke: What is their potential? Stroke. 2006;37:2181-8. https://doi.org/10.1161/01.STR.0000229883.72010.e4
  32. 유병찬, 강경원, 오영선, 임승민, 조현경, 김윤식 등. 뇌졸중의 위험지표로서 의미가 있는 비만 지수는 무엇인가?: 환자-대조군 연구. 대한한방내과학회지. 2008:fal:71-92.
  33. Lewington S, Whitlock G, Clarke R et al. Blood cholesterol and vascular mortality by age, sex, and blood pressure: a meta analysis of individual data from 61 prospective studies with 55,000 vascular deaths. The Lancet. 2007;370(9602):1829-39. https://doi.org/10.1016/S0140-6736(07)61778-4
  34. Barter P, Gotto AM, LaRosa JC et al. HDL cholesterol, very low levels of LDL cholesterol, and cardiovascular events. The New England Journal of Medicine. 2007;357(13):1301-10. https://doi.org/10.1056/NEJMoa064278
  35. Clarke R, Emberson JR, Parish S et al. Cholesterol fractions and apolipoproteins as risk factors for heart disease mortality in older men. Archives of Internal Medicine. 2007;167(13):1373-8. https://doi.org/10.1001/archinte.167.13.1373
  36. Koren-Morag N, Tanne D, Graff E, Goldbourt U. Low- and high-density lipoprotein cholesterol and ischemic cerebrovascular disease: the bezafibrate infarction prevention registry. Arch Intern Med. 2002;162:993-9. https://doi.org/10.1001/archinte.162.9.993
  37. Tirschwell DL, Smith NL, Heckbert SR, Lemaitre RN, Longstreth WT Jr., Psaty BM. Association of cholesterol with stroke risk varies in stroke subtypes and patient subgroups. Neurology. 2004;63:1868-75. https://doi.org/10.1212/01.WNL.0000144282.42222.DA
  38. Wannamethee SG, Shaper AG, Ebrahim S. HDL-Cholesterol, total cholesterol, and the risk of stroke in middle-aged British men. Stroke. 2000;31:1882-8. https://doi.org/10.1161/01.STR.31.8.1882
  39. 김종환, 신우진, 장자원, 김지윤, 민성순, 황원덕. 급성기 뇌졸중 환자의 한양방 협진치료에 대한 임상적 고찰. 대한한방내과학회지. 2004;25(4):65-74.