The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
권호 표지

The Effect of Yangganhwadam-tang(YHT) on Hypertension

양간화담탕(凉肝化痰湯)이 고혈압에 마치는 영향

  • Oh, Yong-Sung (Dept. of Internal Medicine College of Oriental Medicine, Dae-Jeon University) ;
  • An, Joung-Jo (Dept. of Internal Medicine College of Oriental Medicine, Dae-Jeon University) ;
  • Jo, Hyun-Kyung (Dept. of Internal Medicine College of Oriental Medicine, Dae-Jeon University) ;
  • Yoo, Ho-Rhyong (Dept. of Internal Medicine College of Oriental Medicine, Dae-Jeon University) ;
  • Seol, In-Chan (Dept. of Internal Medicine College of Oriental Medicine, Dae-Jeon University) ;
  • Kim, Yoon-Sik (Dept. of Internal Medicine College of Oriental Medicine, Dae-Jeon University)
  • 오용성 (대전대학교 한의과대학 심계내과학교실) ;
  • 안정조 (대전대학교 한의과대학 심계내과학교실) ;
  • 조현경 (대전대학교 한의과대학 심계내과학교실) ;
  • 유호룡 (대전대학교 한의과대학 심계내과학교실) ;
  • 설인찬 (대전대학교 한의과대학 심계내과학교실) ;
  • 김윤식 (대전대학교 한의과대학 심계내과학교실)
  • Published : 2009.12.30
Download PDF
⟨ Previous Next ⟩

Abstract

This experiment was performed to determine the antihypertensive effect of Yangganhwadam-tang(YHT) on hypertension in spontaneously hypertensive rat. The results obtained were as follows : 1. YHT showed scavenging activity on DPPH free radical and SOD-like activity. 2. YHT significantly decreased heart weight. 3. YHT significantly decreased blood pressure and pulse. 4. YHT significantly decreased the level of plasma aldosterone. 5. YHT significantly decreased the level of norepinephrine. 6. YHT significantly decreased the levels of potassium and calcium. 7. YHT significantly decreased the level of BUN. 8. YHT decreased eosinophilic changes in the heart cells, and dilated renal arterioles stenosis. These results suggest that YHT might be effective in treatment and prevention of hypertension.

Keywords

References

  1. 전국한의과대학 심계내과학교실. 심계내과학. 서울: 군자출판사; 2008, p. 154-62.
  2. 의학교육연수원 편. 가정의학. 서울: 서울대학교 출판부; 2003, p. 414-25.
  3. World Health Organization(WHO). World Health Statistic. 2007.
  4. 통계청. 2007년 사망원인통계. 2008.
  5. 이영우. 순환기학. 서울: 일조각; 2003, p. 193-216.
  6. 대한내과학회. 내과학. 서울: MIP; 2003, p. 215-7.
  7. Koike G. Current and future strategy for antihypertensive medication. Folica Pharmacol, Jpn. 2006;127:393-8. https://doi.org/10.1254/fpj.127.393
  8. Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL Jr, et al. The seventh report of the Joint National Committee on prevention, detection, evaluation, and treatment of high blood pressure: the JNC 7 report. JAMA. 2003;289(19):2560-72. https://doi.org/10.1001/jama.289.19.2560
  9. Akiyama, S. Blood clinical data and drug side-effects that require attention during physical therapy. Rigakuryoho kagaku. 2005; 20(1):69-73. https://doi.org/10.1589/rika.20.69
  10. Strauch B, Petrak O, Wichterle D, Zelinka T, Holaj R, Widimsky J Jr. Increased arterial wall stiffness in primary aldosteronism in comparison with essential hypertension. Am J hypertension. 2006;19(9):909-14. https://doi.org/10.1016/j.amjhyper.2006.02.002
  11. 屈松柏, 李家庚 主編. 實用中醫心血管病學. 北京: 科學技術文獻出版社; 1993, p. 347-54.
  12. 何紹奇 主編. 現代中醫內科學. 北京: 醫藥科技出版社; 1991, p. 263-8.
  13. 백경민, 조현경, 유호룡, 김윤식, 설인찬. 加味滋陰降火湯이 SHR의 혈압에 미치는 영향. 대한한방내과학회. 2006;27(1):1-15.
  14. 문형권, 조현경, 유호룡, 설인찬, 김윤식. 加味除 濕順氣湯이 고혈압에 미치는 영향. 동의생리병리학회지. 2006;20(4):887-95.
  15. 송낙근, 구영선, 김동희. 加味四物湯이 고혈압 병태 모델과 활성산소에 미치는 영향. 동의생리병리학회지. 2007;20(6):1485-96.
  16. 송영용, 홍 석, 김동희, 전상윤. 加味天麻鉤藤飮이 고혈압 병태모델에 미치는 영향. 동의생리병리학회지. 2007;21(2):504-10.
  17. 박경호, 최학주, 노성수, 구영선, 김동희. 청열도담탕이 고혈압에 미치는 영향. 동의생리병리학회지. 2007;21(3):626-33.
  18. 김은혜, 안정조, 조현경, 유호룡, 설인찬, 김윤식. 天麻鉤藤飮加味方이 고혈압에 미치는 영향. 동의생리병리학회지. 2007;21(5) :1176-84.
  19. 이영헌, 전상윤, 홍 석, 조국령, 김남욱, 정종안, 강성인. 加味順氣活血湯이 DOCA-salt로 유발된 고혈압 흰 쥐에 미치는 작용기전. 동의생리병리학회지. 2008;22(1):162-70.
  20. Burt VL, Whelton P, Roccella EJ, Brown C, Cutler JA, Higgins M, et al. Prevalence of hypertensive in the US adult populations. Hypertension 1995;25:305-14. https://doi.org/10.1161/01.HYP.25.3.305
  21. Vasan RS, Beiser A, Seshadri S, Larson MG, Kannel WB, D'Agostino RB. et al. Residual lifetime risk for developing hypertension in middle-aged women and men: the framingham heart study. JAMA. 2002;287(8) :1003-10. https://doi.org/10.1001/jama.287.8.1003
  22. 해리슨내과학 편찬위원회 편. 해리슨내과학 제1권, 서울: 도서출판 정담; 1997, p. 445-59, 1202-20.
  23. 장남섭, 김영식, 박영우, 정순희, 이한기, 백홍석. 생리학. 서울: 수문사; 2005, p. 128-34.
  24. 의학교육연수원. 약물요법. 서울: 서울대학교출판부; 1988, p. 135-9.
  25. 李迎雨, 吳秉熙, 金哲鎬. 고혈압. 서울: 고려의학; 2000, p. 11-55
  26. 전국한의과대학 본초학교수 공편. 본초학. 서울: 도서출판 영림사; 1994, p. 146-7, 167-8, 169-70, 193-5, 287-8, 347-9, 427-8, 466-7, 503-4, 511-2, 581-3, 540-1, 578-80, 600-1.
  27. Dhawan, V, Jain, S. Effect of garlic supplementation on oxidized low density lipoproteins and lipid peroxidation in patients of essential hypertension. Mol Cell Biochem. 2004;266(1-2):109-15.
  28. Greenwald RA. Superoxide dismutase and catalase as therapeutic agents for human diseases: a critical review. Free Radic Biol Med. 1990;8(2):201-9. https://doi.org/10.1016/0891-5849(90)90092-W
  29. Kitani K, Minami C, Yamamoto T, Kanai S, Ivy GO, Carrillo MC. Pharmacological interventions in aging and age-associated disorders: potentials of propargylamines for human use. Ann N Y Acad Sci. 2002;959:295-307.
  30. Wilson, SK. Role of oxygen-derived free radicals in acute angiotensin II-induced hypertensive vascular disease in the rat. Circ Res. 1990;66(3):722-34. https://doi.org/10.1161/01.RES.66.3.722
  31. U Ackermann. Regulation of arterial blood pressure. Surgery (Oxford). 2004;22(5):120a-120f. https://doi.org/10.1383/surg.22.5.120a.33383
  32. Navar, LG, Harrison-Bernard, LM, Nishiyama, A, Kobori, H. Regulation of intrarenal angiotensin II in hypertension. Hypertension. 2002;39(2 Pt 2):316-22. https://doi.org/10.1161/hy0202.103821
  33. 성호경, 김기환. 생리학. 서울: 의학문화사; 1996, p. 374-6.
  34. Booth, RE, Johnson, JP, Stockand, JD. Aldosterone. Adv Physiol Educ. 2002;26:8-20.
  35. Buss SJ, Backs J, Kreusser MM, Hardt SE, Maser-Gluth C, Katus HA, et al. Spironolactone preserves cardiac norepinephrine reuptake in salt-sensitive Dahl rats. Endocrinology. 2006;147(5):2526-34. https://doi.org/10.1210/en.2005-1167
  36. Takase B, Akima T, Satomura K, Ohsuzu F, Mastui T, Ishihara M, et al. Effects of chronic sleep deprivation on autonomic activity by examining heart rate variability, plasma catecholamine, and intracellular magnesium levels. Biomed Pharmacother. 2004;1:S35-9.
  37. 대한내분비학회. 내분비학. 서울: 고려의학; 1999, p. 532-45.
  38. 대한병리학회. 병리학. 서울: 고문사; 1995, p. 112-22.
  39. 30명의 의과대학교수편 역. 생리학. 서울: 한우리; 1999, p. 778-80.
  40. Feig DI, Nakagawa T, Karumanchi SA, Oliver WJ, Kang DH, Finch J, et al. Hypothesis: Uric acid, nephron number, and the pathogenesis of essential hypertension. Kidney Int. 2004;66(1):281-7. https://doi.org/10.1111/j.1523-1755.2004.00729.x
  41. Kang DH, Nakagawa T, Feng L, Watanabe S, Han L, Mazzali M, et al. A role for uric acid in the progression of renal disease. J Am Soc Nephrol. 2002;13(12):2888-97. https://doi.org/10.1097/01.ASN.0000034910.58454.FD
  42. 진호준, 나기영, 김연수, 채동완, 김성권. 한국인에서 고요산혈증 및 대사증후군이 고혈압의 발생에 미치는 영향. 대한내과학회지. 2007;73(1):58-66.
  43. 이귀녕, 권오헌. 임상병리파일. 서울: 의학문화사; 2003, p. 95-8, 102-5.