대한간호학회지 (Journal of Korean Academy of Nursing)

한국간호과학회 (Korean Society of Nursing Science)
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일측성 좌골신경손상이 쥐의 정상측 뒷다리근에 미치는 영향

Effects of Unilateral Sciatic Nerve Injury on Unaffected Hindlimb Muscles of Rats

  • 발행 : 2009.06.26
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초록

Purpose: The purpose of this study was to examine the effects of unilateral sciatic nerve injury on unaffected hindlimb muscles of rats. Methods: Adult male Sprague-Dawley rats were assigned to one of three groups: control(C) group(n=10) that had no procedures, sham(S) group(n=10) that underwent sham left sciatic nerve transection, and sciatic nerve transection(SNT) group(n=9) that underwent left sciatic nerve transection. At 15 days rats were anesthetized, and the soleus, plantaris and gastrocnemius muscles were dissected. Results: Muscle weight of the unaffected plantaris muscle in the SNT group was significantly lower than in the other two groups. Type II fiber cross-sectional areas of the unaffected plantaris and gastrocnemius muscles in the SNT group were significantly smaller than in the other two groups. The decrease of muscle weights and Type I, II fiber cross-sectional areas of the unaffected three muscles in the SNT group were significantly less than that of the affected three muscles. Conclusion: Hindlimb muscle atrophy occurs in the unaffected side after unilateral sciatic nerve injury, with changes in the plantaris and gastrocnemius muscle being more apparent than changes in the soleus muscle. These results have implications for nursing care, in the need to assess degree of muscle atrophy in unaffected muscles as well as affected muscles.

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참고문헌

  1. Brooke, M. H., & Kaiser, K. K. (1970). Muscle fiber types: How many and what kind? Archives of Neurology, 23, 369-379 https://doi.org/10.1001/archneur.1970.00480280083010
  2. Choe, M. A., & An, G. J. (2007). Effects of exercise before steroid treatment on type I and type II hindlimb muscles in a rat model. Journal of Korean Academy of Nursing, 37, 81-90
  3. Choe, M. A., & Chi, J. G. (1993). Effect of periodic weight support on type I muscle of developing suspended rats. -Animal experiment for nursing intervention of muscle atrophy in children. Journal of Korean Academy of Nursing, 23, 207-223
  4. Choe, M. A., Chi, J. G., & Kim, E. H. (1995). Effect of intermittent low-intensity, short duration exercise on type II muscle of suspended rats. Journal of Korean Academy of Nursing, 25, 193-209
  5. Choe, M. A., An, G. J., Lee, Y. K., Im, J. H., Choi-Kwon, S., & Heitkemper, M. (2004). Effect of inactivity and undernutrition after acute ischemic stroke in a rat hindlimb muscle model. Nursing Research, 53, 283-292 https://doi.org/10.1097/00006199-200409000-00001
  6. Chung, I. S. (1975). Effects of d-amphetamine and chlorpromazine on the orienting response and general behavioral activity in rats. Unpublished doctoral dissertation, Seoul National University, Seoul
  7. Cuccurullo, S. (Ed.). (2004). Physical medicine and rehabilitation board review. New York, NY: Demos
  8. Hagiwara, Y., Hatori, M., Kokubun, S., & Miyasaka, Y. (2003). Gait characteristics of sciatic nerve palsy-A report of four cases. Upsala Journal of Medical Sciences, 108, 221-227 https://doi.org/10.3109/2000-1967-116
  9. Herbison, G. J., Jaweed, M. M., & Ditunno, J. F. (1979). Muscle atrophy in rats following denervation, casting, inflammation, and tenotomy. Archives of Physical Medicine and Rehabilitation, 60, 401-404
  10. Hyun, J. K., Lee, S. J., Yoo, D. S., Park, H. G., & Kwon, B. S. (2004). The electrodiagnostic findings of sciatic nerve injury according to the locations and etiologies. Journal of Korean Academy of Rehabilitation Medicine, 28, 54-58
  11. Imaizumi, K., Tachiyashiki, K., & Jikihara, K. (1996). Responses of visceral organ size and skeletal muscle mass during whole body suspension and recovery in rats. Advances in Exercise and Sports Physiology, 2, 19-29
  12. Jakobsson, F., Borg, K., Edstro_m, L., & Grimby, L. (1988). Use of motor units in relation to muscle fiber type and size in man. Muscle &Nerve, 11, 1211-1218 https://doi.org/10.1002/mus.880111205
  13. Kim, D. H., Kwon, O. Y., Kim, Y. S., Kim, S. H., Son, S. N., Park, K. J., et al. (2004). A case of bilateral sciatic neuropathy caused by lotus position. Journal of the Korean Neurological Association, 22, 418-420
  14. Kotani, Y., Wang, Z., Furuyama, T., Sato, Y., Mori, N., & Yamashita, H. (2002). Effects of aging and denervation on the expression of uncoupling proteins in slow- and fast-twitch muscles of rats. Journal of Biochemistry, 132, 309-315 https://doi.org/10.1093/oxfordjournals.jbchem.a003225
  15. Lee, J. H., & Lee, K. R. (1990). Effect of electrical stimulation on the denervated muscle of the albino rat, sprague-dawley. The Journal of Korean Society of Physical Therapy, 2, 47-63
  16. Llovera, M., Garcia-Martinez, C., Agell, N., Lopez-Soriano, F. J., & Argiles, J. M. (1997). TNF can directly induce the expression of ubiquitin-dependent proteolytic system in rat soleus muscles. Biochemical and Biophysical Research Communications, 230, 238-241 https://doi.org/10.1006/bbrc.1996.5827
  17. Ma, Q. P., Tian, L., & Woolf, C. J. (2000). Resection of sciatic nerve re-triggers central sprouting of A-fibre primary afferents in the rat. Neuroscience Letters. 288, 215-218 https://doi.org/10.1016/S0304-3940(00)01242-8
  18. Ogard, W. K., & Stockert, B. W. (1995). Peripheral neuropathies. In D. A. Umphred (Ed.), Neurological rehabilitation (3rd ed.) (pp. 360-374). St. Louis, MO: Mosby
  19. Park, K. C., Kim, K. W., & Kim, Y. H. (2005). Combined femoral and sciatic nerve palsy associated with acetabular fracture and dislocation-A case report. Journal of Korean Fracture Society, 18, 341-344
  20. Sakakima, H., Yoshida, Y., Morimoto, N., & Sakae, K. (2002). The effect of denervation and subsequent reinnervation on the morphology of rat soleus muscles. Journal of Physical Therapy Science, 14, 21-26 https://doi.org/10.1589/jpts.14.21
  21. Thomason, D. B., & Booth F. W. (1990). Atrophy of the soleus muscle by hindlimb unweighting. Journal of Applied Physiology, 68, 1-12 https://doi.org/10.1063/1.347115
  22. van Meeteren N. L., Brakkee J. H., Hamers F. P., Helders P. J., & Gispen W. H. (1997). Exercise training improves functional recovery and motor nerve conduction velocity after sciatic nerve crush lesion in the rat. Archives of Physical Medicine and Rehabilitation, 78, 70-77 https://doi.org/10.1016/S0003-9993(97)90013-7
  23. Yoon, B. C., Yu, B. K., & Lee, M. H. (2000). Exercise effects on the atrophy of denervated muscles in rat. Journal of the Korean Academy of University Trained Physical Therapists, 7(3), 34-48

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