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Regulation of Tumor Immune Surveillance and Tumor Immune Subversion by TGF-$\beta$

  • Park, Hae-Young (Laboratory of Immunology, Lee Gil-Ya Cancer and Diabetes Institute, Gachon University of Medicine and Science) ;
  • Wakefield, Lalage M (Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health) ;
  • Mamura, Mizuko (Laboratory of Immunology, Lee Gil-Ya Cancer and Diabetes Institute, Gachon University of Medicine and Science)
  • Received : 2009.06.20
  • Accepted : 2009.06.23
  • Published : 2009.08.31
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Abstract

Transforming growth factor-$\beta$ (TGF-$\beta$) is a highly pleiotropic cytokine playing pivotal roles in immune regulation. TGF-$\beta$ facilitates tumor cell survival and metastasis by targeting multiple cellular components. Focusing on its immunosuppressive functions, TGF-$\beta$ antagonists have been employed for cancer treatment to enhance tumor immunity. TGF-$\beta$ antagonists exert anti-tumor effects through #1 activating effector cells such as NK cells and cytotoxic $CD8^+$ Tcells (CTLs), #2 inhibiting regulatory/suppressor cell populations, #3 making tumor cells visible to immune cells, #4 inhibiting the production of tumor growth factors. This review focuses on the effect of TGF-$\beta$ on T cells, which are differentiated into effector T cells or newly identified tumor-supporting T cells.

Keywords

References

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