Usefulness of Minimally Invasive Radio-Guided Parathyroidectomy in Patients with Prior Central Neck Exploration

중앙 경부 수술의 과거력이 있는 환자에서의 방사능 유도 최소 침습 부갑상선 절제술의 유용성

  • Lee, Sung-Hwan (Thyroid Cancer Center, Department of Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine) ;
  • Kim, Bup-Woo (Thyroid Cancer Center, Department of Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine) ;
  • Kim, Kuk-Jin (Thyroid Cancer Center, Department of Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine) ;
  • Lee, Yong-Sang (Thyroid Cancer Center, Department of Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine) ;
  • Jeong, Jong-Ju (Thyroid Cancer Center, Department of Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine) ;
  • Nam, Kee-Hyun (Thyroid Cancer Center, Department of Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine) ;
  • Chung, Woong-Youn (Thyroid Cancer Center, Department of Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine) ;
  • Chang, Hang-Seok (Thyroid Cancer Center, Department of Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine) ;
  • Park, Cheong-Soo (Thyroid Cancer Center, Department of Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine)
  • 이성환 (연세대학교 의과대학 외과학교실, 강남세브란스병원 갑상선암센터) ;
  • 김법우 (연세대학교 의과대학 외과학교실, 강남세브란스병원 갑상선암센터) ;
  • 김국진 (연세대학교 의과대학 외과학교실, 강남세브란스병원 갑상선암센터) ;
  • 이용상 (연세대학교 의과대학 외과학교실, 강남세브란스병원 갑상선암센터) ;
  • 정종주 (연세대학교 의과대학 외과학교실, 강남세브란스병원 갑상선암센터) ;
  • 남기현 (연세대학교 의과대학 외과학교실, 강남세브란스병원 갑상선암센터) ;
  • 정웅윤 (연세대학교 의과대학 외과학교실, 강남세브란스병원 갑상선암센터) ;
  • 장항석 (연세대학교 의과대학 외과학교실, 강남세브란스병원 갑상선암센터) ;
  • 박정수 (연세대학교 의과대학 외과학교실, 강남세브란스병원 갑상선암센터)
  • Published : 2009.11.30

Abstract

Introduction : Although bilateral exploration has been thought to be the standard therapeutic modality for primary hyperparathyroidism(pHPT) due to the admirable cure rate, questions have remained as to whether bilateral neck exploration for all patients with pHPT is needed because 80-85% of patients with pHPT have a single parathyroid adenoma. If the diseased parathyroid can be determined preoperatively, a directed and minimal operation is appropriate using the recent innovations of preoperative diagnosis and operation techniques for parathyroid diseases, the radio-guided parathyroid surgery(RGPS) is one of the standards. In especial, RGPS has been reported beneficial in special circumstances, such as in recurrent disease, ectopic parathyroid, and in mediastinal parathyroid. It can be also useful for the parathyroid disease in previously explored or irradiated neck. Material and Methods : We experienced 2 cases of pHPT successfully treated by RGPS in who previously underwent extensive neck dissection and concomitant external or internal radiotherapy. We adopted and modified the technique described by Dr. James Norman at the University of South Florida-the minimally invasive parathyroidectomy using intraoperative nuclear mapping with 99mTc-sestamibi scanning and radioactivity detection probe. Results : We acquired the successful results for these patients. Conclusion : RGPS is thought to be the alternative technique for the patients with prior central neck exploration and irradiation.

Keywords

References

  1. Wang C. Surgical management of primary hyperparathyroidism. Curr Probl Surg. 1985;22:4-50 https://doi.org/10.1016/0011-3840(85)90019-X
  2. ReMine SG. Management of recurrent or persistent hyperparathyroidism. Probl Gen Surg. 1985;2:440-449
  3. Denham D, Norman J. Cost effectiveness of preoperative sestamibi scan for primary hyperparathyroidsm is dependent soley on surgeon's choice of operative procedure. J Am Coll Surg. 1998;186:293-304 https://doi.org/10.1016/S1072-7515(98)00016-7
  4. Yeng HC, Ng WT, Kong CK. Endoscopic thyroid and parathyroid surgery. Surg Endosc. 1997;11:1135 https://doi.org/10.1007/s004649900551
  5. Udelsman R, Donovan PI, Sokoll LJ. One hundred consecutive minimally invasive parathyroid explorations: Ann Surg. 2000; 232:331-339 https://doi.org/10.1097/00000658-200009000-00005
  6. Norman J, Chheda H. Minimally invasive parathyroidectomy fascillitated by intraopertive nuclear mapping. Surgery. 1997;122: 998-1004 https://doi.org/10.1016/S0039-6060(97)90201-4
  7. Norman J, Denham D. Minimally invasive radioguided parathyroidectomy in the reoperative neck. Surgery. 1998;124:1088-1092 https://doi.org/10.1067/msy.1998.92007
  8. Inabnet WB, Dakin GF, Haber RS, Rubino F, Diamond EJ, Gagner M. Targeted parathyroidectomy in the era of intraoperative parathormone monitoring. World J Surg. 2002;26:921-925 https://doi.org/10.1007/s00268-002-6619-7
  9. Purcell GP, Derbas FM, Jeffrey RB, Lane Mi, Desser T, Mc-Dougall IR, et al. Parathyroid localization with high-resolution ultrasound and technetium Tc-99m sestamibi. Arch Surg. 1999;134:824-830 https://doi.org/10.1001/archsurg.134.8.824
  10. Gagner M. Endoscopic parathyroidectomy. Br J Surg. 1996;83:875 https://doi.org/10.1002/bjs.1800830656
  11. Micolli P, Berti P, Materazzi G, Donatini G. Minimally invasive video assisted parathyroidectomy. Eur J Surg Oncol. 2003;29:188-190 https://doi.org/10.1053/ejso.2002.1313
  12. Miura D, Wada N, Arici C, Morita E, Duh QY, Clark OH. Does intraoperative quick parathyroid hormone assay improve the results of parathyroidectomy? World J Surg. 2002;26:926-930 https://doi.org/10.1007/s00268-002-6620-1
  13. Feo ML, Colagrande S, Biagini C, Tonarelli A, Bisi G, Vaggelli L, et al. Parathyroid glands: Combination of Tc-99m MIBi scintigraphy and ultrasonography for demonstration of parathyroid glands and nodules. Radiology. 2000;214:393-402 https://doi.org/10.1148/radiology.214.2.r00fe04393
  14. Clark OH, Duh QY, Siperstein AE, Wilkes W. Diagnosis and management of asymptomatic hyperparathyroidism: Safety, efficacy, and deficiencies in our knowledge. J Bone Miner Res. 1991;6: S135-S142 https://doi.org/10.1002/jbmr.5650061428
  15. Mundschenk J, Lose S, Lorenz K, Dralle H, Lehnert H. Diagnostic strategies and surgical procedures in persistent or recurrent primary hyperparathyroidism. Exp Clin Endocrinol Diabetes. 1999;107:331-336 https://doi.org/10.1055/s-0029-1212122
  16. Norman JG, Jaffrary CE, Chedda H. The false-positive parathyroid scan: A real or perceived problem and a case for radioguided parathyroidectomy. Ann Surg. 2000;231:31-37 https://doi.org/10.1097/00000658-200001000-00005
  17. Agarwal G, Barraclough BH, Reeve TS, Delbridge LW. Minimally invasive parathyroidectomy using the 'focused' lateral approach. II. Surgical technique. ANZ J Surg. 2002;72:147-151 https://doi.org/10.1046/j.1445-2197.2002.02332.x
  18. Henry JF, Raffaelli M, Jacobone M, Volot F. Video-assisted parathyroidectomy via the lateral approach vs conventional surgery in treatment of sporadic primary hyperparathyroidism. Surg Endosc. 2001;10:1116-1119 https://doi.org/10.1007/s00464-001-9013-x
  19. Chung WY, Chang HS, Lee JD, Park CS. Minimally invasive radio-guided parathyroid surgery. Korean J Head Neck Oncol. 1999;15:194-199
  20. Inabnet WB. The use of radioguided parathyroidectomy in persistent or recurrent hyperparathyroidism. Ann Surg. 2001;233:453 https://doi.org/10.1097/00000658-200103000-00022
  21. Yun JS, Lee YS, Jung JJ, Nam KH, Chung WY, Park CS. Central neck recurrence patterns and morbidity following reoperation for recurrent papillary thyroid carcinoma. J Korean Surgical Society. 2008;74:42-47