Korean Journal of Head & Neck Oncology (대한두경부종양학회지)

The Korean Society for Head and Neck Oncology (대한두경부종양학회)
권호 표지

Clinical Manifestation and Treatment Results of the Extranodal Marginal Zone B-Cell Lymphoma of Mucosa-Associated Lymphoid Tissue Arising in the Head and Neck Region

두경부의 점막연관 림프조직에서 발생한 림프절외 변연부 B세포 림프종의 임상 양상 및 치료 결과에 대한 고찰

  • Rah, Yoon-Chan (Department of Otorhinolaryngology, Seoul National University College of Medicine) ;
  • Han, Kyu-Hee (Department of Otorhinolaryngology, Seoul National University College of Medicine) ;
  • An, Soo-Youn (Department of Otorhinolaryngology, Seoul National University College of Medicine) ;
  • Kwon, Tack-Kyun (Department of Otorhinolaryngology, Seoul National University College of Medicine) ;
  • Sung, Myung-Whun (Department of Otorhinolaryngology, Seoul National University College of Medicine) ;
  • Kim, Kwang-Hyun (Department of Otorhinolaryngology, Seoul National University College of Medicine) ;
  • Hah, J.-Hun (Department of Otorhinolaryngology, Seoul National University College of Medicine)
  • 나윤찬 (서울대학교 의과대학 이비인후과학교실) ;
  • 한규희 (서울대학교 의과대학 이비인후과학교실) ;
  • 안수연 (서울대학교 의과대학 이비인후과학교실) ;
  • 권택균 (서울대학교 의과대학 이비인후과학교실) ;
  • 성명훈 (서울대학교 의과대학 이비인후과학교실) ;
  • 김광현 (서울대학교 의과대학 이비인후과학교실) ;
  • 하정훈 (서울대학교 의과대학 이비인후과학교실)
  • Published : 2009.11.30
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Abstract

Objectives : Mucosa-associated lymphoid tissue(MALT) lymphoma of the head and neck region is relatively rare, but it has variable clinical and biological characteristics. Although there were few studies on this topic, there is still controversy regarding the best treatment. The authors retrospectively investigated the clinical courses and treatment results in 10 patients presenting with MALT-lymphoma in head and neck region except ocular adnexa. Material and Methods : Ten patients with a histologically verified diagnosis of the extranodal marginal zone B cell lymphoma arising in thyroid glands(3), larynx(3), oral cavity(2), oropharynx(1), salivary glands(1) were analyzed. Results : Four patients were allocated to stage IE and another six patients to stage IIE according to the Ann Arbor staging system. Treatment consisted of local therapy(surgical resection and/or radiotherapy) in four patients and systemic chemotherapy with/without local therapy in six patients. Complete remission and partial remission were achieved in seven patients(70%) and two patients(20%), respectively. No recurrence or mortality was observed with a mean follow-up of 40.5 months. Conclusion : Patients with MALT-lymphomas of the head and neck region were potentially treated by local modality in localized disease state. However systemic chemotherapy was also effective even in localized disease state and was well tolerated by patients. And strict staging and close long-term monitoring were recommended considering its indolent progression.

Keywords

References

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