Journal of Animal Science and Technology

Korean Society of Animal Sciences and Technology (한국축산학회)
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Effects of Dietary Garlic Powder on Growth Performance and mRNA Expression of Hepatic HMG-CoA Reductase in Broiler Chickens

육계 사료 내 마늘분말의 첨가급여가 육계 성장과 HMG-CoA Reductase의 mRNA 발현에 미치는 영향

  • You, Sun-Jong (Animal Resources Research Center, College of Animal Bioscience and Technology, Konkuk University) ;
  • Ahn, Byoung-Ki (Animal Resources Research Center, College of Animal Bioscience and Technology, Konkuk University) ;
  • Kang, Chang-Won (Animal Resources Research Center, College of Animal Bioscience and Technology, Konkuk University)
  • 유선종 (건국대학교 동물생명과학대학 동물자원연구센터) ;
  • 안병기 (건국대학교 동물생명과학대학 동물자원연구센터) ;
  • 강창원 (건국대학교 동물생명과학대학 동물자원연구센터)
  • Received : 2009.02.20
  • Accepted : 2009.07.14
  • Published : 2009.08.01
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Abstract

This experiment was conducted to investigate the effects of dietary garlic powder (GP) on growth performance and mRNA expression of hepatic 3-hydroxy-3-methylglutaryl-CoA reductase (HMG-CoA reductase) in broiler chickens. Day-old male chicks (Ross, n=270) were fed diets containing 0% [positive control (PC) with antibiotics or negative control (NC) without antibiotics], 1%, 3% and 5% GP for 6 wks. There were no significant differences in feed intake among the treatments throughout the experimental period. Body weight gains in groups fed dietary GP at 3% and 5% were significantly higher than that of NC group (P<0.05). Feeding GP up to 5% did not exert any adverse effect on weight gain and feed intake. There were no significant differences in the relative weights of liver, spleen, cecum and breast muscle. The content of meat cholesterol in GP containing dietary groups tended to be reduced as compared to NC group. Average infectious bronchitis antibody titers in chicks fed GP containing diets were significantly higher than that of NC group (P<0.05). The mRNA expression of hepatic HMG-CoA reductase was reduced by dietary GP. These results indicate that dietary GP has growth promoting effects and tended to alter cholesterol metabolism in broiler chickens.

육계사료 내 마늘분말의 첨가급여가 육계의 성장성적과 간 HMG-CoA reductase의 발현에 미치는 영향을 규명하기 위해 본 연구를 수행하였다. 1일령의 육계 Ross 수평아리에게 마늘분말을 0%(항생제 첨가 또는 항생제 무첨가), 1%, 3% 및 5%의 수준으로 첨가한 실험사료를 각각 6주간 급여하였다. 증체량은 항생제 무첨가 대조구에 비하여 마늘분말 3% 및 5%를 첨가한 처리구에서 유의하게 증가하였으며(P<0.05), 사료섭취량은 처리구간 차이가 없었다. 육계 사료 내 5%까지의 마늘분말의 첨가급여는 증체량과 사료섭취량에 부정적인 영향을 주지 않았다. 간, 비장, 맹장 및 가슴 근육에 대한 상대적 중량은 처리가 유의한 차이가 관찰되지 않았다. 근육 내 콜레스레롤 함량은 항생제 첨가 대조구에 비해 감소하였으나 통계적인 유의차는 나타나지 않았다. IB 항체 생성량은 항생제 무첨가 대조구에 비하여 유의적으로 증가하였다(P<0.05). 간의 HMGCoA reductase mRNA의 발현은 대조구에 비해 마늘분말을 첨가한 모든 처리구에서 저하된 것으로 관찰되었다. 본 연구에서 사료 내 마늘의 첨가급여는 육계의 성장촉진 효과를 나타내었으며, 콜레스테롤 대사에 영향을 미칠 수 있음이 시사되었다.

Keywords

References

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