YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Total Synthesis of Hepatoprotective Isowogonin and a Synthetic Approach to Wogonin

간보호 효과를 나타내는 Isowogonin의 전합성 및 Wogonin 합성을 위한 반응조건 탐색

  • Kim, Kwang-Sik (College of Pharmacy, Institute of Pharmaceutical Research and Development, Wonkwang University) ;
  • Kim, Hak-Sung (College of Pharmacy, Institute of Pharmaceutical Research and Development, Wonkwang University)
  • Received : 2009.12.20
  • Accepted : 2009.12.24
  • Published : 2009.12.31
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Abstract

Isowogonin, 5,8-dihydroxy-7-methoxyflavone, is a flavonoid isolated from the root of Scutellaria baicalensis Georgi, a medicinal plant traditionally used since the ancient time. It was thought to possess a variety of biological activities, such as antioxidation, anti-inflammation and hepatoprotective effect. But a quantity of isowogonin obtained from Scutellaria baicalensis Georgi is not that enough for in vivo test. There have been no appropriate approaches available for a facile synthesis of isowogonin. So we describe a concise and efficient scheme for synthesis of isowogonin from a commercial available 2,4,6-trimethoxyphenol, which includes the Fries rearrangement and selective demethylation as key steps.

Keywords

References

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