Radiation Oncology Journal

The Korean Society for Radiation Oncology (대한방사선종양학회)
권호 표지
DOI QR코드

DOI QR Code

A Case Report of Intraocular Metastasis Treated with Radiotherapy

방사선치료를 시행한 전이성 안구암 1예

  • Kim, Ok-Bae (Departments of Radiation Oncology, Keimyung University School of Medicine) ;
  • Byun, Sang-Jun (Departments of Radiation Oncology, Keimyung University School of Medicine) ;
  • Kim, Kwang-Soo (Departments of Ophthalmology, Keimyung University School of Medicine) ;
  • Lee, Ho-Jun (Department of Radiation Oncology, Daegu Catholic University School of Medicine) ;
  • Kim, Jin-Hee (Departments of Radiation Oncology, Keimyung University School of Medicine)
  • 김옥배 (계명대학교 의과대학 방사선종양학교실) ;
  • 변상준 (계명대학교 의과대학 방사선종양학교실) ;
  • 김광수 (계명대학교 의과대학 안과학교실) ;
  • 이호준 (대구가톨릭대학교 의과대학 방사선종양학교실) ;
  • 김진희 (계명대학교 의과대학 방사선종양학교실)
  • Received : 2009.04.30
  • Accepted : 2009.06.25
  • Published : 2009.09.30
Download PDF
⟨ Previous Next ⟩

Abstract

Intraocular metastasis is the most common malignancy of the eye. The frequency of intraocular metastasis in all the patients dying of cancer is about 12% and ocular metastases will be detected more frequently in the future because the patients with malignant tumor are now living longer. Intraocular metastasis can cause a serious clinical problem such as blindness. The early recognition and treatment of intraocular metastasis are very important clinical oncologic issues to maintain vision and to maximize the quality of life. However, significance of intraocular metastasis is still under-evaluated for practicing oncologists. External beam radiotherapy is a safe, effective palliative treatment in terms of preserving both the vision and the eye globe.

안구의 전이암은 안구의 악성 종양 중에서 가장 흔한 암이다. 많게는 암으로 인해 사망한 환자의 약 12%에서 안구의 전이가 보고되며, 암 환자의 생존 기간이 늘어남에 따라 안구로의 전이 가능성 또한 증가할 것으로 추정된다. 안구 전이는 실명과 같은 심각한 임상적 증상을 야기할 수 있으며, 조기 발견과 치료를 통해 시력을 보존하고 삶의 질을 최대화 할 수 있으나, 암 환자에 있어 안구 전이의 중요성은 비교적 낮게 평가되고 있다. 안구 전이에 대한 방사선치료는 국소치료이므로 전신적인 부작용이 없으며, 치료에 대한 반응이 조기에 나타나므로 실명 위기에 있는 안구 전이 환자에게 효과적인 치료법이 될 수 있다.

Keywords

References

  1. Perls M. Contributions to the pathology of tumors. Virchows Arch Pathol Anat 1872;56:437-467 https://doi.org/10.1007/BF01973432
  2. Eliassi-Rad B, Albert DM, Green WR. Frequency of ocular metastases in patients dying of cancer in eye bank populations. Br J Ophthalmol 1996;80:125-128 https://doi.org/10.1136/bjo.80.2.125
  3. Nelson CC, Hertzberg BS, Klintworth GK. A histopathologic study of 716 unselected eyes in patients with cancer at the time of death. Am J Ophthalmol 1983;95:788-793 https://doi.org/10.1016/0002-9394(83)90066-1
  4. Bloch RS, Gartner S. The incidence of ocular metastatic carcinoma. Arch Ophthalmol 1971;85:673-675 https://doi.org/10.1001/archopht.1971.00990050675005
  5. Maor M, Chan RC, Young SE. Radiotherapy of choroidal metastases: breast cancer as primary site. Cancer 1977;40:2081-2086 https://doi.org/10.1002/1097-0142(197711)40:5<2081::AID-CNCR2820400515>3.0.CO;2-O
  6. Freedman MI, Folk JC. Metastatic tumors to the eye and orbit: patient survival and clinical characteristics. Arch Ophthalmol 1987;105:1215-1219 https://doi.org/10.1001/archopht.1987.01060090073031
  7. Shields CL, Shields JA, Gross NE, Schwartz GP, Lally SE. Survey of 520 eyes with uveal metastases. Ophthalmology 1997;104:1265-1276 https://doi.org/10.1016/S0161-6420(97)30148-1
  8. Godtfredsen E. On the frequency of secondary carcinomas in the choroid. Acta Ophthalmol 1944;22:394-400 https://doi.org/10.1111/j.1755-3768.1944.tb07467.x
  9. Brady LW, Shields JA, Augsburger JJ, Day JL. Malignant intraocular tumors. Cancer 1982;49:578-585 https://doi.org/10.1002/1097-0142(19820201)49:3<578::AID-CNCR2820490330>3.0.CO;2-A
  10. Minatel E, Trovo MG, Forner L, et al. The efficacy of radiotherapy in the treatment of intraocular metastases. Br J Radiol 1993;66:699-702 https://doi.org/10.1259/0007-1285-66-788-699
  11. Rudoler SB, Shields CL, Corn BW, et al. Functional vision is improved in the majority of patients treated with external external-beam radiotherapy for choroid metastases: a multivariate analysis of 188 patients. J Clin Oncol 1997;15:1244-1251 https://doi.org/10.1200/JCO.1997.15.3.1244
  12. Rudoler SB, Corn BW, Shields CL, et al. External beam irradiation for choroid metastases: identification of factors predisposing to long-term sequelae. Int J Radiat Oncol Biol Phys 1997;38:251-256 https://doi.org/10.1016/S0360-3016(97)00050-3
  13. Letson AD, Davidorf FH, Bruce RA Jr. Chemotherapy for treatment of choroidal metastases from breast carcinoma. Am J Ophthalmol 1982;93:102-106 https://doi.org/10.1016/0002-9394(82)90707-3
  14. Dobrowsky W. Treatment of choroid metastases. Br J Radiol 1988;61:140-142 https://doi.org/10.1259/0007-1285-61-722-140
  15. Mewis L, Young SE. Breast carcinoma metastatic to the choroid:analysis of 67 patients. Ophthalmology 1982;89:147-151 https://doi.org/10.1016/S0161-6420(82)34838-1
  16. Tkocz HJ, Hoffmann S, Schnabel K, et al. Bilateral radiotherapy in cases of one-sided choroidal metastases. Front Radiat Ther Oncol 1997;30:160-164