Radiation Oncology Journal

The Korean Society for Radiation Oncology (대한방사선종양학회)
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A Dose Volume Histogram Analyzer Program for External Beam Radiotherapy

방사선치료 관련 연구를 위한 선량 체적 히스토그램 분석 프로그램 개발

  • Kim, Jin-Sung (Department of Radiation Oncology, Samsung Medical Center, Sungkyunkwan University, College of Medicine) ;
  • Yoon, Myong-Geun (Proton Therapy Center, National Cancer Center) ;
  • Park, Sung-Yong (Proton Therapy Center, National Cancer Center) ;
  • Shin, Jung-Suk (Department of Radiation Oncology, Samsung Medical Center, Sungkyunkwan University, College of Medicine) ;
  • Shin, Eun-Hyuk (Department of Radiation Oncology, Samsung Medical Center, Sungkyunkwan University, College of Medicine) ;
  • Ju, Sang-Gyu (Department of Radiation Oncology, Samsung Medical Center, Sungkyunkwan University, College of Medicine) ;
  • Han, Young-Yih (Department of Radiation Oncology, Samsung Medical Center, Sungkyunkwan University, College of Medicine) ;
  • Ahn, Yong-Chan (Department of Radiation Oncology, Samsung Medical Center, Sungkyunkwan University, College of Medicine)
  • 김진성 (성균관대학교 의과대학 삼성서울병원 방사선종양학교실) ;
  • 윤명근 (국립암센터 양성자치료센터) ;
  • 박성용 (국립암센터 양성자치료센터) ;
  • 신정석 (성균관대학교 의과대학 삼성서울병원 방사선종양학교실) ;
  • 신은혁 (성균관대학교 의과대학 삼성서울병원 방사선종양학교실) ;
  • 주상규 (성균관대학교 의과대학 삼성서울병원 방사선종양학교실) ;
  • 한영이 (성균관대학교 의과대학 삼성서울병원 방사선종양학교실) ;
  • 안용찬 (성균관대학교 의과대학 삼성서울병원 방사선종양학교실)
  • Received : 2009.08.12
  • Accepted : 2009.09.29
  • Published : 2009.12.31
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Abstract

Purpose: To provide a simple research tool that may be used to analyze a dose volume histogram from different radiation therapy planning systems for NTCP (Normal Tissue Complication Probability), OED (Organ Equivalent Dose) and so on. Materials and Metohds: A high-level computing language was chosen to implement Niemierko's EUD, Lyman-Kutcher-Burman model's NTCP, and OED. The requirements for treatment planning analysis were defined and the procedure, using a developed GUI based program, was described with figures. The calculated data, including volume at a dose, dose at a volume, EUD, and NTCP were evaluated by a commercial radiation therapy planning system, Pinnacle (Philips, Madison, WI, USA) for comparison. Results: The volume at a special dose and a dose absorbed in a volume on a dose volume histogram were successfully extracted using DVH data of several radiation planning systems. EUD, NTCP and OED were successfully calculated using DVH data and some required parameters in the literature. Conclusion: A simple DVH analyzer program was developed and has proven to be a useful research tool for radiation therapy.

목 적: 방사선치료 관련 연구를 수행함에 있어서 선량 체적 히스토그램(dose volume histogram, DVH)을 분석하는 것이 필수적이나 상용 방사선치료계획시스템에서 수행할 수 없다. 본 연구는 이러한 선량 체적 히스토그램의 정보를 쉽게 분석할 수 있도록 소프트웨어를 제작하였다. 대상 및 방법: 방사선치료계획 시스템에서 치료계획 후에 환자의 DVH 데이터를 텍스트로 저장하여 이를 이용해서 DVH 상에서의 필요한 특정 값들(Vx, Dx)을 지정하여 획득할 수 있도록 하였고, Niemierko의 generalized equivalent uniform dose (EUD), Lyman-Kutcher-Burman 모델을 이용한 normal tissue complication probability (NTCP) 및 방사선치료의 2차 암유발 위험도 인자인 organ equivalent dose (OED)를 계산하는 프로그램을 개발하였다. 결 과: 환자의 데이터를 가지고 실제 방사선치료계획 시스템 상에서의 Vx, Dx와 NTCP 비교를 통해 개발된 프로그램의 계산 알고리즘을 검증하였고 0.1% 내의 오차를 보였으며 EUD 및 OED도 성공적으로 계산되었다. 결 론: 선량 체적 히스토그램을 분석하는 프로그램을 개발하였으며 다양한 방사선치료 관련 연구에 활용할 수 있을 것으로 예상된다.

Keywords

References

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