The Journal of Korean Obstetrics and Gynecology (대한한방부인과학회지)

The Society of Korean Medicine Obstetrics and Gynecology (대한한방부인과학회)
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Fermented Artemisiae Argyi Folium and Epimedii Herba Mixture Effect on Macrophage' Activity

애엽과 음양곽 혼합 발효물이 대식세포 활성에 미치는 영향

  • Ryu, Hahn-Woo (Dept. of Gynecology, College of Oriental Medicine, Kyungwon University) ;
  • Kim, Yoon-Sang (Dept. of Gynecology, College of Oriental Medicine, Kyungwon University) ;
  • Lee, Eun-Mee (Dept. of Gynecology, College of Oriental Medicine, Kyungwon University)
  • 류한우 (경원대학교 한의과대학 부인과학교실) ;
  • 김윤상 (경원대학교 한의과대학 부인과학교실) ;
  • 임은미 (경원대학교 한의과대학 부인과학교실)
  • Published : 2009.05.29
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Abstract

Purpose: This research aimed to study the effect of FAE(Ferment Artemisiae Argyi Folium and Epimedii Herba) on the mouse macrophage cell activity. Methods: Effect of FAE, which was fermented by Sacchromyces cerevisiae STV89, on cell viability, amount of $H_2O_2$ within cells, amount of NO was measured and compaperd by using mouse macrophage cells. Results: 1. Result of MTT assay conducted to observe the effect of FAE on the survival rate of mouse macrophage cells illustrated that, when FAE was proccessed for each concentration, there was no significant decrease of the survival rate. 2. FAE increased the amount of $H_2O_2$ within macrophage cells and increased inhibition of amount of $H_2O_2$ in macrophage induced by LPS. 3. FAE inhibited amount of NO in macrophage cells, and significantly inhibited increase of amount of NO in mcacrophage induced by LPS. Conclusion: FAE produced by Artemisiae Argyi Folium and Epimedii Herba did not induce the decrease of macrophage cell survival rate, increased amount of $H_2O_2$ within cells, and reduced amount of NO. FAE significantly increase by LPS, reduced the increase of amount of NO in macrophage induced by LPS. These results signify FAE has significant effect on immuno modulating activity of macrophage.

Keywords

References

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