생명과학회지 (Journal of Life Science)

  • 제19권5호
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  • Pages.688-691
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  • 2009
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  • 1225-9918(pISSN)
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  • 2287-3406(eISSN)
한국생명과학회 (Korean Society of Life Science)
권호 표지
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참외추출물이 스코폴라민 유도 기억상실 흰쥐의 인지능 회복에 미치는 효과

Cognition Enhancing Effect of Muskmelon (Cucumis melo) Extracts on Scopolamine-induced Memory Impairment in Mice

  • 박상신 (동국대학교 경주캠퍼스 과학기술대학 바이오학부) ;
  • 박나오미 (동국대학교 경주캠퍼스 과학기술대학 바이오학부) ;
  • 강주억 (동국대학교 경주캠퍼스 과학기술대학 바이오학부) ;
  • 신석철 (동국대학교 경주캠퍼스 과학기술대학 바이오학부) ;
  • 이동웅 (동국대학교 경주캠퍼스 과학기술대학 바이오학부)
  • 발행 : 2009.05.30
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초록

The methanol extract of muskmelon (Cucumis melo) has been investigated for its cognition enhancing effects by evaluation of inhibitory activities on acetylcholinesterase, a degrading enzyme of acetylcholine, a brain neurotransmitter, and ${\beta}$- secretase, which forms the ${\beta}$-amyloid toxic protein from its precursor protein. A passive avoidance task, one of the animal model experiments for learning and memory, was also performed. As a result, the melon extract showed 15.8% and 35.3% inhibition on acetylcholinesterase and ${\beta}$-secretase, respectively, with a final concentration of 100 mg/ml. In the animal model test, melon extract significantly (p<0.05) lengthened the step-through latency time by 22.7% compared to the control group, suggesting that melon extract has, indeed, an effect on cognition enhancement.

키워드

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