The Journal of Korean Medicine (대한한의학회지)

The Society of Korean Medicine (대한한의학회)
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Four-week Repeated Dose Toxicity Test for Myelophil in SD Rats

  • Jung, Jong-Mi (Department of Internal Medicine, Daejeon Oriental Hospital, Daejeon University) ;
  • Shin, Jang-Woo (Institute of Traditional Medicine and Bioscience, Daejeon University) ;
  • Son, Jin-Young (Institute of Traditional Medicine and Bioscience, Daejeon University) ;
  • Seong, Nak-Won (Safety Assessment Center, Korea Testing and Research Institute for Chemical Industry) ;
  • Seo, Dong-Seok (Safety Assessment Center, Korea Testing and Research Institute for Chemical Industry) ;
  • Cho, Jung-Hyo (Department of Internal Medicine, Daejeon Oriental Hospital, Daejeon University) ;
  • Cho, Chong-Kwan (Department of Internal Medicine, Daejeon Oriental Hospital, Daejeon University) ;
  • Son, Chang-Gue (Department of Internal Medicine, Daejeon Oriental Hospital, Daejeon University)
  • Published : 2009.05.30
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Abstract

Aim : To evaluate the pharmaceutical safety of the herbal formula Myelophil, composed of Astragali Radix and Salviae Radix, via systemic subacute toxicological study using SD rats. Methods : Forty male and 40 female SD rats were fed with Myelophil (5000, 2500 or 1250 mg/10 mL/kg) or distilled water for four weeks. Adverse effects were examined intensively by comparing the differences between normal and drug-administered groups using clinical signs, necropsies, histopathologic findings, hematology, urinalysis, and blood biochemical analysis. Results : No altered clinical symptoms including body weight, diarrhea, anorexia, death, and abnormal necropsy of major organs were observed in male or female rats. No drug-induced abnormalities in histopathological finding, hematological values, urinalysis, and blood biochemical values were found at any doses of Myelophil. Conclusion : Myelophil should be very safe when used in a clinical application with a wide therapeutic index.

Keywords

References

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