Maxillofacial Plastic and Reconstructive Surgery

Korean Association of Maxillofacial Plastic and Reconstructive Surgeons (대한악안면성형재건외과학회)
권호 표지

ORAL MANIFESTATION AND TREATMENT OF ACUTE MYELOID LEUKEMIA: A CASE REPORT

급성 골수성 백혈병의 구강 내 발현 및 치료: 증례 보고

  • Kim, Ji-Youn (Department of Oral and Maxillofacial Surgery, School of Dentistry, Seoul National University) ;
  • Min, Seung-Ki (Department of Oral and Maxillofacial Surgery, School of Dentistry, Seoul National University) ;
  • Lim, Ho-Kyung (Department of Oral and Maxillofacial Surgery, School of Dentistry, Seoul National University) ;
  • Suh, Jin-Won (Department of Oral and Maxillofacial Surgery, School of Dentistry, Seoul National University) ;
  • Hwang, Soon-Jung (Department of Oral and Maxillofacial Surgery, School of Dentistry, Seoul National University)
  • 김지연 (서울대학교 치의학대학원 구강악안면외과학교실) ;
  • 민승기 (서울대학교 치의학대학원 구강악안면외과학교실) ;
  • 임호경 (서울대학교 치의학대학원 구강악안면외과학교실) ;
  • 서진원 (서울대학교 치의학대학원 구강악안면외과학교실) ;
  • 황순정 (서울대학교 치의학대학원 구강악안면외과학교실)
  • Received : 2009.08.10
  • Accepted : 2009.11.12
  • Published : 2009.11.20
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Abstract

Proliferation of abnormal hematopoietic cells with impaired differentiation, regulation and programmed cell death leads to leukemia. AML(acute myeloid leukemia) is a malignancy with malfunction of myeloid hematopoietic cells with acute behavior. The oral manifestations of the disease are posterior palate hemorrhage, gingival bleeding and gingival ulceration as a result of infection by normal oral flora and gingival infiltration by leukemic cells. A 49-year-old male patient was referred from local dental clinic. The patient was diagnosed with AML FAB M1 (acute myeloid leukemia French-American-British classification M1 myeloblastic leukemia without maturation). The oral infection focus was removed by a conservative treatment. 2 days after the dental treatment, the patient underwent chemotherapy. At 8-month follow-up, the overall outcome was excellent. Oral manifestations of AML are often the first indications of the malignancy. Therefore it is essential for dentists, especially oral and maxillofacial surgeons, to be aware of the diagnostic signs and complications associated with leukemia for better diagnosis and subsequent treatment and management.

Keywords

References

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