Journal of Yeungnam Medical Science
- Volume 26 Issue 2
- /
- Pages.143-147
- /
- 2009
- /
- 2799-8010(eISSN)
A Case of Intravesical Cidofovir Treatment of BK Virus-Associated Hemorrhagic Cystitis after Allogeneic Peripheral Blood Stem Cell Transplantation
동종말초조혈모세포이식 후 발생한 BK 바이러스 출혈성 방광염의 Cidofovir 방광 내 주입 치험 1례
- Kang, Seong-Hun (Department of Internal Medicine, Daegu Fatima Hospital) ;
- Lee, Hwa-Jeong (Department of Internal Medicine, Daegu Fatima Hospital) ;
- Jang, Ye-Su (Department of Internal Medicine, Daegu Fatima Hospital) ;
- Ji, Jun-Ho (Department of Internal Medicine, Daegu Fatima Hospital) ;
- Lee, Sun-Ah (Department of Internal Medicine, Daegu Fatima Hospital) ;
- Lee, Won-Sik (Department of Internal Medicine, Daegu Fatima Hospital) ;
- Lee, Jung-Lim (Department of Internal Medicine, Daegu Fatima Hospital) ;
-
Lee, Kyung-Hee
(Department of Internal Medicine, College of Medicine, Yeungnam University)
- 강성훈 (대구파티마병원 내과) ;
- 이화정 (대구파티마병원 내과) ;
- 장예수 (대구파티마병원 내과) ;
- 지준호 (대구파티마병원 내과) ;
- 이선아 (대구파티마병원 내과) ;
- 이원식 (대구파티마병원 내과) ;
- 이정림 (대구파티마병원 내과) ;
-
이경희
(영남대학교병원 내과)
- Published : 2009.12.30
Abstract
Hemorrhagic cystitis (HC) is a common complication after allogeneic transplantation. Early posttransplant HC occurs in association with cyclophosphamide, while later on HC results from viral infections such as polyomavirus BK (BKV) and adenovirus. We report here the case of a 57-year-old woman who received an instillation of cidofovir into the bladder for the treatment of hemorrhagic cystitis after allogeneic peripheral stem cell transplantation for her acute myeloid leukemia. Cyclophosphamide and busulfan were used as conditioning treatments. Cyclosporin was administered daily. On the 71st day after transplantation, the patient developed acute severe hemorrhagic cystitis, and BK virus was demonstrated in the urine samples using polymerase chain reaction. Her urinary symptoms did not improve in spite of palliative treatment, but a response was evident after intravesical cidofovir treatment.