Journal of Yeungnam Medical Science

Yeungnam University College of Medicine, Yeungnam University Institute Medical Science (영남대 의대 학술지 편집위원회)
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A Case of Colchicine-Induced Neutropenia in Liver Cirrhosis Patient

간경변 환자에서 콜히친 사용에 의한 호중구성 백혈구감소증 1예

  • Lee, Ho-Chan (Department of Internal Medicine, College of Medicine, Yeungnam University) ;
  • Lee, Heon-Ju (Department of Internal Medicine, College of Medicine, Yeungnam University) ;
  • Kim, Yong-Gil (Department of Internal Medicine, College of Medicine, Yeungnam University) ;
  • Park, Jae-Hyun (Department of Internal Medicine, College of Medicine, Yeungnam University) ;
  • Kim, Sung-Joon (Department of Internal Medicine, College of Medicine, Yeungnam University) ;
  • Park, Jun-Seok (Department of Internal Medicine, College of Medicine, Yeungnam University)
  • 이호찬 (영남대학교 의과대학 내과학교실) ;
  • 이헌주 (영남대학교 의과대학 내과학교실) ;
  • 김용길 (영남대학교 의과대학 내과학교실) ;
  • 박재현 (영남대학교 의과대학 내과학교실) ;
  • 김성준 (영남대학교 의과대학 내과학교실) ;
  • 박준석 (영남대학교 의과대학 내과학교실)
  • Published : 2009.12.30
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Abstract

Colchicine is an alkaloid that has been used for treating acute gouty arthritis, psoriasis, scleroderma and Behcet's syndrome. Colchicine decreased liver fibrosis in rats with carbon tetrachloride induced cirrhosis and in patients with many liver diseases. Therapeutic oral doses of colchicine may cause nausea, vomiting, abdominal pain and diarrhea. The adverse effect of colchicine associated with the dose is bone marrow suppression, and especially neutopenia. Neutropenia has often been reported in patients have taken an overdose of colchicine. We describe a 64-year-old female liver cirrhosis patient with neutropenia that was induced by a therapeutic dose of colchicine.

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