Maxillofacial Plastic and Reconstructive Surgery

  • 제31권1호
  • /
  • Pages.1-7
  • /
  • 2009
  • /
  • 2288-8101(pISSN)
  • /
  • 2288-8586(eISSN)
대한악안면성형재건외과학회 (Korean Association of Maxillofacial Plastic and Reconstructive Surgeons)
권호 표지

가토의 측두하악관절원판 결손에서 간세포 성장인자가 치유에 미치는 영향

EFFECT OF HEPATOCYTE GROWTH FACTOR ON THE REPAIR OF DEFECT IN THE ARTICULAR DISC IN RABBIT TEMPOROMANDIBULAR JOINT

  • 김복주 (동아대학교의료원 치과학교실 구강악안면외과) ;
  • 성화식 (부산대학교 치의학전문대학원 구강악안면외과학교실) ;
  • 김철훈 (동아대학교의료원 치과학교실 구강악안면외과) ;
  • 김규천 (부산대학교 치의학전문대학원 해부학교실) ;
  • 황희성 (동아대학교의료원 치과학교실 구강악안면외과) ;
  • 신상훈 (부산대학교 치의학전문대학원 구강악안면외과학교실)
  • Kim, Bok-Joo (Department of Oral & Maxillofacial surgery, Department of Dentistry, Dong-A University Medical Center) ;
  • Seong, Hwa-Sik (Department of Oral & Maxillofacial surgery, College of Dentistry, Busan National University) ;
  • Kim, Chul-Hoon (Department of Oral & Maxillofacial surgery, Department of Dentistry, Dong-A University Medical Center) ;
  • Kim, Gyoo-Cheon (Department of Oral Anatomy, College of Dentistry, Busan National University) ;
  • Hwang, Hee-Sung (Department of Oral & Maxillofacial surgery, Department of Dentistry, Dong-A University Medical Center) ;
  • Shin, Sang-Hun (Department of Oral & Maxillofacial surgery, College of Dentistry, Busan National University)
  • 발행 : 2009.01.31
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Purpose: The purpose of this study is to investigate the therapeutic use of Hepatocyte growth factor(Adv.CMV.HGF) in temporomandibular joint disc defect. Materials and methods: Twelve New Zealand white rabbits, weighing 2.5 - 3.0 kg, were used in this experiment. Defects(2 mm in diameter) were created in their TMJ discs. Recombinant Adv.CMV.HGF with gelatin sponge($Gelfoam^{(R)}$) as carrier was implanted in the defects. We divided the rabbits into four batches according to the duration of the implantation - of 1, 4, 8, 12 weeks - and both left and right TMJ of each rabbit in all groups were used in the research : left joints were used as experiment group and right were control group. Each batch of rabbits was killed one, four, eight and twelve weeks after the experimentation respectively, and called Group A, B, C, and D. (Group A = 1 wk, B = 4 wks, C = 8 wks, and D = 12 wks) Results: The experimental group showed a significant increase in the number of chondroblasts and active cell differentiation at the margin of the defects. Compared to the control group, in the experiment group chondroblasts increased and chondrocytes showed a columnar arrangement, which is witnessed at the time of cell differentiation. Conclusion: This study supports the case that Avd.CMV.HGF may be useful in the repair of articular disc of the rabbit TMJ.

키워드

참고문헌

  1. Wakitani S, Imoto K : Hepatocyte growth factor facilitates cartilage repair. Acta Orthop Scand 68 : 474-480, 1997 https://doi.org/10.3109/17453679708996266
  2. Grano M, Galimi F, Zambonin G et al : Hepatocyte growth factor is a coupling factor for osteoclasts and osteoblasts in vitro. Proc Natl Acad Sci USA 93 : 7644-7648, 1996 https://doi.org/10.1073/pnas.93.15.7644
  3. Blanquaert F, Delany AM, Canalis E : Fibroblast growth factor-2 induces hepatocyte growth factor/scatter factor expression in osteoblasts. Endocrinology 140 : 1069-1074, 1999 https://doi.org/10.1210/en.140.3.1069
  4. Fuller K, Ewens J, Chambers TJ : The effect of hepatocyte growth factor on the behavior of osteoclasts. Biochem Biophys Res Commun 212 : 334-340, 1995 https://doi.org/10.1006/bbrc.1995.1974
  5. Skrtic S, Ohlsson C : Cortisol decreases hepatocyte growth factor levels in human osteoblast-like cells. Calcif Tissue Int 66 : 108-112, 2000 https://doi.org/10.1007/PL00005831
  6. Takai K, Hara J, Matsumoto K et al : Hepatocyte growth factor is consititutively produced by human bone marrow stromal cells and indirectly promotes hematopoiesis. Blood 89 : 1560-1565, 1997
  7. Weimar IS, Miranda N, Muller EJ et al : Hepatocyte growth factor/scatter factor(HGF/SF) is produced by human bone marrow stromal cells and promotes proliferation, adhesion and survival of human hematopoietic progenitor cells($CD34^{+}$). Exp Hematol 26 : 885-894, 1998
  8. Amano O, Koshimizu U, Nakamura T et al : Enhancement by hepatocyte growth factor of bone and cartilage formation during embryonic mouse mandibular development in vitro. Arch Oral Biol 44 ; 935-946, 1999 https://doi.org/10.1016/S0003-9969(99)00086-2
  9. G. D’ippolito, PC Schiller, C Perez-Stable et al : Cooperative Actions of Hepatocyte Growth Factor and 1,25-Dihydroxy vitamin D3 in Osteoblastic Differation of Human Vertebral Bone Marrow Stromal Cells. Bone 31 : 269-275, 2002 https://doi.org/10.1016/S8756-3282(02)00820-7
  10. Takebayashi T, Myoukai F, Koyama E, et al : Hepatocyte growth factor/scatter factor modulates cell motility, proliferation, and proteoglycan synthesis of chondrocytes. J Cell Biol 129 : 1411-1419, 1995 https://doi.org/10.1083/jcb.129.5.1411
  11. Wakitani S, Imoto K, Kimura T et al : Hepatocyte growth factor facilitates cartilage repair. Full thickness articular cartilage defect studied in rabbit knees. Acta Orthop Scand 68 : 474-480, 1997 https://doi.org/10.3109/17453679708996266
  12. Giovanni Z, Claudia C, Giobanni G et al : Hydroxyapatite coated with hepatocyte growth factor(HGF) stimulates human osteoblasts in vitro. J bone Joint surg[Br] 82-B : 457, 2000
  13. Quan Dai, Laura Manfield, Tao Wang et al : Adenovirusmediated gene transfer to healing tendon-enhanced efficiency using a gelatin sponge. J Orthopaedic Research 21 : 604-609, 2003 https://doi.org/10.1016/S0736-0266(02)00239-5
  14. Busolino F, Di Renzo MF, Ziche M et al : Hepatocyte growth factor is a potent angiogenic factor which stimulates endothelial cell motility and growth. J Cell Biol 119 : 629-641, 1992 https://doi.org/10.1083/jcb.119.3.629
  15. Roos F, Ryan AM, Chamow SM et al : Induction of liver growth in normal mice by infusion of hepatocyte growth factor/scatter factor. Am J Physiol 268 : G380-G386, 1995
  16. Takayama H, LaRochelle WJ, Anver M et al : Scatter factor/ hepatocyte growth factor as a regulator of skeletal muscle and neural crest development. Proc Natl Acad Sci USA 93 : 5866-5871, 1996 https://doi.org/10.1073/pnas.93.12.5866
  17. Yaskashiwa M, Nakayama S, Ohnuma K et al : Simultaneous or delayed administration of hepatocyte growth factor (HGF) equally repress the fibrotic change in murine lung injury induced by bleomycric a morphogenic study. Am J Reap Crit Care Med 158 : 1937-1944, 1997
  18. Birchmeier C, Gharardi E : Developmental roles of HGF/SF and its receptor, c-Met tyrosine kinase. Trends Cell Biol 8 : 404-409, 1998 https://doi.org/10.1016/S0962-8924(98)01359-2
  19. Balkovota DF, Lipochutz IH : Hepatocyte growth factor and the kidney: it is just not for the liver. Int Rev Cytol 188 : 225-260, 1999
  20. Zarnegar R, Michalopoulos GK : The many faces of hepatocyte growth factor from hepatopoiesis. J Cell Biol 129 : 1177-1180, 1995 https://doi.org/10.1083/jcb.129.5.1177
  21. Matsumoto K, Nakamura T : Hepatocyte growth factor (HGF) as a tissue organizer for organogenesis and regeneration. Biochem Biophys Res Commun 239 : 639-644, 1997 https://doi.org/10.1006/bbrc.1997.7517
  22. Kopp JB : Hepatocyte growth factor. mesenchymal signal for epithelial homeostasis. Kidney Int 54 : 1392-1393, 1998 https://doi.org/10.1046/j.1523-1755.1998.00126.x
  23. Van Bolle E, Wizanbichter B, Chon D et al :Potential angiogenic effect of scatter factor/hepatocyte growth factor via induction of vascular endothelial growth factor. the case for paracrine amplification of angiogenesis. Circulation 97 : 381-390, 1998 https://doi.org/10.1161/01.CIR.97.4.381
  24. Morishita R, Nakamura S, Hayashi S et al : Therapeutic angiogenesis induced by human recombinant hepatocyte growth factor in rabbit hind limb ischemia model as cytokine supplement therapy. Hypertension 33 : 1379-1384, 1999 https://doi.org/10.1161/01.HYP.33.6.1379
  25. Miszuno S, Matsumoto K, Kurosawa T et al : Reciprocal balance of hepatocyte growth factor and transforming growth factor-$\beta$1 in renal fibrosis in mice. Kidney Int 57 : 937-948, 2000 https://doi.org/10.1046/j.1523-1755.2000.00910.x
  26. Matsuda Y, Matsumoto K, Ichida T et al : Hepatocyte growth factor suppresses the onset of liver cirrhosis and abrogates lethal hepatic dysfunction in rats. J Biochem 118 : 643-649, 1995
  27. Yasuda H, Imai E, Shiota A et al : Anti-fibrogenic effect of a deletion variant of hepatocyte growth factor on liver fibrosis in rats. Hepatology 24 : 638-642, 1996 https://doi.org/10.1053/jhep.1996.v24.pm0008781336
  28. Minuno S, Kurosawa T, matsumoto K et al : Hepatocyte growth factor prevents renal fibrosis and dysfunction in a mouse model of chronic renal disease. J Clin Invest 113 : 1827-1834, 1998 https://doi.org/10.1172/JCI1709
  29. Kosai K, Matsumoto K, Nakamura T : Hepatocyte growth factor prevents endotoxin-induced lethal hepatic failure in mice. Hepatology 30 : 151-159, 1999 https://doi.org/10.1002/hep.510300102
  30. Tahara M, Matsumoto K, Nukiwa T et al : Hepatocyte growth factor leads to recovery from alcohol-induced fatty liver in rats. J Clin Invest 103 : 313-320, 1999 https://doi.org/10.1172/JCI4433
  31. Ueki T, Kanada Y, Tsutiu H et al : Hepatocyte growth factor gene therapy of liver chirrhosis in rats. Nature Med 5 : 226-230, 1999 https://doi.org/10.1038/5593
  32. Takada S, Takushuwa S, Nakamura K et al : Effect of hepatocyte growth factor on tacrolimus-induced nephrotoxicity in spontaneously hypertensive rats. Transplant Int 12 : 27-32, 1999 https://doi.org/10.1111/j.1432-2277.1999.tb00572.x
  33. Rashid M. A, Akita S, Razzaque M. S et al : Coadministration of basic fibroblast growth factor and sucrose octasulfate(sucral-fate) facilitates the rat dorsal flap survival and viability. Plast Reconstr Surg 103 : 941-948, 1999 https://doi.org/10.1097/00006534-199903000-00026
  34. Krebsbach PH, Mankani MH, Satomura K et al : Repair of crainotomy defect using bone marrow stromal cells. Transplantation 66 : 1272-1278, 1998 https://doi.org/10.1097/00007890-199811270-00002