Maxillofacial Plastic and Reconstructive Surgery

Korean Association of Maxillofacial Plastic and Reconstructive Surgeons (대한악안면성형재건외과학회)
권호 표지

EFFECT OF HEPATOCYTE GROWTH FACTOR ON THE REPAIR OF DEFECT IN THE ARTICULAR DISC IN RABBIT TEMPOROMANDIBULAR JOINT

가토의 측두하악관절원판 결손에서 간세포 성장인자가 치유에 미치는 영향

  • Kim, Bok-Joo (Department of Oral & Maxillofacial surgery, Department of Dentistry, Dong-A University Medical Center) ;
  • Seong, Hwa-Sik (Department of Oral & Maxillofacial surgery, College of Dentistry, Busan National University) ;
  • Kim, Chul-Hoon (Department of Oral & Maxillofacial surgery, Department of Dentistry, Dong-A University Medical Center) ;
  • Kim, Gyoo-Cheon (Department of Oral Anatomy, College of Dentistry, Busan National University) ;
  • Hwang, Hee-Sung (Department of Oral & Maxillofacial surgery, Department of Dentistry, Dong-A University Medical Center) ;
  • Shin, Sang-Hun (Department of Oral & Maxillofacial surgery, College of Dentistry, Busan National University)
  • 김복주 (동아대학교의료원 치과학교실 구강악안면외과) ;
  • 성화식 (부산대학교 치의학전문대학원 구강악안면외과학교실) ;
  • 김철훈 (동아대학교의료원 치과학교실 구강악안면외과) ;
  • 김규천 (부산대학교 치의학전문대학원 해부학교실) ;
  • 황희성 (동아대학교의료원 치과학교실 구강악안면외과) ;
  • 신상훈 (부산대학교 치의학전문대학원 구강악안면외과학교실)
  • Published : 2009.01.31
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Abstract

Purpose: The purpose of this study is to investigate the therapeutic use of Hepatocyte growth factor(Adv.CMV.HGF) in temporomandibular joint disc defect. Materials and methods: Twelve New Zealand white rabbits, weighing 2.5 - 3.0 kg, were used in this experiment. Defects(2 mm in diameter) were created in their TMJ discs. Recombinant Adv.CMV.HGF with gelatin sponge($Gelfoam^{(R)}$) as carrier was implanted in the defects. We divided the rabbits into four batches according to the duration of the implantation - of 1, 4, 8, 12 weeks - and both left and right TMJ of each rabbit in all groups were used in the research : left joints were used as experiment group and right were control group. Each batch of rabbits was killed one, four, eight and twelve weeks after the experimentation respectively, and called Group A, B, C, and D. (Group A = 1 wk, B = 4 wks, C = 8 wks, and D = 12 wks) Results: The experimental group showed a significant increase in the number of chondroblasts and active cell differentiation at the margin of the defects. Compared to the control group, in the experiment group chondroblasts increased and chondrocytes showed a columnar arrangement, which is witnessed at the time of cell differentiation. Conclusion: This study supports the case that Avd.CMV.HGF may be useful in the repair of articular disc of the rabbit TMJ.

Keywords

References

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