Journal of Biomedical Engineering Research (대한의용생체공학회:의공학회지)

The Korean Society of Medical and Biological Engineering (대한의용생체공학회)
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The Fluorescence Immunoassay of lung Cancer Serum Diomarkers using Quantum dots

  • Kang, Ji-Min (Medical Nano Element Development Center, Samsung Medical Center) ;
  • Ahn, Jin-Seok (Medical Nano Element Development Center, Samsung Medical Center) ;
  • Kim, Jin-Hoon (Medical Nano Element Development Center, Samsung Medical Center) ;
  • Kong, Won-Ho (Medical Nano Element Development Center, Samsung Medical Center) ;
  • Park, Keun-Chil (Medical Nano Element Development Center, Samsung Medical Center) ;
  • Kim, Won-Seog (Medical Nano Element Development Center, Samsung Medical Center) ;
  • Seo, Soo-Won (Medical Nano Element Development Center, Samsung Medical Center)
  • Published : 2009.04.30
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Abstract

Cancer serum biomarkers have advanced our ability to more accurately predict tumor classification, prognostic/metastatic potential, and response potential to novel chemotherapies. Serum amyloid A (SAA) and Vascular endothelial growth factor (VEGF) have potential utility as a serum biomarker for lung cancer. Quantum dots, nanometer-sized crystals, have a high quantum yield, sensitivity, and pronounced photostability. The properties of quantum dots can be efficiently applied to the detection of serum biomarkers in immunoassays as fluorescent probe. We used quantum dots as fluorescent probes in immunoassays and attempted to detect serum amyloid A and vascular endothelial growth factor as serum biomarkers of lung cancer. This fluorescence immunoassay based on the properties of quantum dots is applicable to the detection of serum biomarkers for lung cancer. The fluorescence immunoassay with quantum dots should allow the efficient and specific detection of serum amyloid A (SAA) for the possible diagnosis of lung cancer.

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References

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