Journal of Adhesion and Interface (접착 및 계면)

The Society of Adhesion and Interface, Korea (한국접착및계면학회)
권호 표지

Preparation of Chitosan Microcapsules Containing Rosmarinic Acid

로즈마리산을 함유한 키토산 마이크로캡슐의 제조

  • Received : 2009.02.02
  • Accepted : 2009.02.19
  • Published : 2009.03.30
Download PDF
⟨ Previous Next ⟩

Abstract

The microcapsules containing rosmarinic acid were prepared in this research. Rosmarinic acid is known that it is effective to care the winkles. Chitosan was used as a wall material, and glutaraldehyde was used as a crosslinking agent, and the microcapsules were prepared by the water-in-oil (W/O) emulsion method. In this method Span80 was used as an emulsifier, and mineral oil was used as a medium material. Perfectly spherical microcapsules were obtained in the size range of $0.5{\sim}0.9{\mu}m$. The effects of emulsifier concentration and stirring speed on the average particle size and distribution, and encapsulation efficiency were investigated. The release behavior of the microcapsules with different amount of the crosslinking agent and different emulsifier concentrations were also investigated.

본 연구에서는 주름 개선 효과가 있는 것으로 알려진 rosmarinic acid를 함유하는 마이크로캡슐을 제조하였다. 벽재 물질로는 키토산을 사용하였고, 글루타르알데히드를 가교제로 사용하였으며, W/O 형태의 유화법으로 마이크로캡슐을 제조하였다. 유화제로는 span80을 사용하였으며, 가교가 시행되는 bath상의 물질은 mineral oil을 사용하였다. 제조된 키토산 마이크로캡슐은 완벽한 구의 형태로 평균 $0.5{\sim}0.9{\mu}m$ 크기를 보였으며, 교반속도와 유화제의 농도에 따른 캡슐의 크기 및 형태 변화 그리고 함유 효율을 관찰하였다. 마이크로캡슐의 방출특성을 실험하기 위하여 가교제와 유화제의 양을 변화시키면서 방출 속도를 측정하였다.

Keywords

References

  1. S. Sosnowski, M. Gadziowski, and S. Slomkowski, Macromolecules, 29, 4556 (1996). https://doi.org/10.1021/ma951542h
  2. R. C. Mehta, B. C. Thanoo, and P. P. Deluca, J. Control. Release, 41, 277 (1996).
  3. R. J. H. Stenekes, O. Franssen, E. M. G. van Bommel, D. J. A. Crommelin, and W. E. Hennink, Int. J. Pharm., 183, 29 (1999). https://doi.org/10.1016/S0378-5173(99)00038-1
  4. S. Y. Jeong, J. H. Choi, and Y. D. Ma, Polymer (Korea), 26, 523 (2002).
  5. B. O'Donnell and J. W. McGinity, Adv. Drug Del. Rev., 28, 25 (1997). https://doi.org/10.1016/S0169-409X(97)00049-5
  6. K. A. Johnson, Adv. Drug Del. Rev., 26, 3 (1997). https://doi.org/10.1016/S0169-409X(97)00506-1
  7. S. Benita, Microencapsulation-Methods and Industrial Applications, Marcel Dekker, New York (1996).
  8. A. Kondo, Microcapsules Processing and Technology, Marcel Dekker, New York (1979).
  9. C. J. Kim and P. I. Lee, Pharm. Res., 9, 10 (1992). https://doi.org/10.1023/A:1018963223484
  10. A. Kim, S. J. Park, and J. R. Lee, J. Colloid Interface Sci., 197, 119 (1998). https://doi.org/10.1006/jcis.1997.5208
  11. S. J. Park and J. R. Lee, J. Colloid Interface Sci., 291, 178 (1999).
  12. T. Kidchob, S. Kimura, and Y. Imanishi, J. Control. Release, 54, 283 (1998). https://doi.org/10.1016/S0168-3659(98)00012-1
  13. S. J. Park, Y. S. Shin, and J. R. Lee, J. Colloid Interface. Sci., 241, 502 (2001). https://doi.org/10.1006/jcis.2001.7727
  14. K. Hirech, S. Payan. G. Carnelle, L. Brujes, and J. Legrand, Powder Technol., 130, 324 (2000).
  15. X. Y. Shi and T. W. Tan, Biomaterials, 23, 4469 (2002). https://doi.org/10.1016/S0142-9612(02)00165-5
  16. R. A. A. Muzzarelli, Chitin, Pergamon Press, New York (1997).
  17. L. Illum, Pharm. Res., 15, 1326 (1998). https://doi.org/10.1023/A:1011929016601
  18. D. K. Singh and A. R. Ray, J. Memb. Sci., 155, 107 (1999). https://doi.org/10.1016/S0376-7388(98)00311-1