Pediatric Infection and Vaccine

The Korean Society of Pediatric Infectious Diseases (대한소아감염학회)
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A Case of Hereditary Spherocytosis with Hemolytic Anemia due to Mycoplasma pneumonia

마이코플라즈마 폐렴에 의해 용혈성 빈혈이 발현된 유전성 구상 적혈구증 1례

  • Na, Hye-Yeon (Department of Pediatrics, College of Medicine, Hallym University) ;
  • Shin, Seon-Hee (Department of Pediatrics, College of Medicine, Hallym University) ;
  • Lee, Kyu-Man (Department of Laboratory Medicine, College of Medicine, Hallym University) ;
  • Kim, Kwang-Nam (Department of Pediatrics, College of Medicine, Hallym University)
  • 나혜연 (한림대학교 의과대학 소아과학교실) ;
  • 신선희 (한림대학교 의과대학 소아과학교실) ;
  • 이규만 (한림대학교 의과대학 진단검사의학교실) ;
  • 김광남 (한림대학교 의과대학 소아과학교실)
  • Received : 2009.08.07
  • Accepted : 2009.09.13
  • Published : 2009.12.25
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Abstract

Mycoplasma pneumoniae is a common cause of community-acquired pneumonia in children, with a peak incidence at 5-14 years. Extrapulmonary manifestations occur in 20-25% of patients with M. pneumoniae infection. Most auto-antibodies that cause immune hemolytic anemia in humans are cold agglutinins. The formation of cold agglutinins is frequently observed during M. pneumoniae infections, and cold agglutinin disease usually occurs during M. pneumoniae infections. Nevertheless, severe hemolysis is exceptional. If a patient has any underlying disease related to hemolysis, it is possible to accelerate hemolysis. Hereditary spherocytosis is a common cause of hereditary hemolytic anemia resulting from red blood cell membrane defects. Hemolysis of red cells may result from corpuscular abnormalities or extracorpuscular abnormalities, such as immune or non-immune mechanisms. We report a case of hereditary spherocytosis associated with severe hemolytic anemia due to Mycoplasma pneumonia.

5-14세에 호발하는 마이코플라즈마 폐렴은 20-25%에서 폐외 증상을 일으키는 것으로 알려져 있으며 이 중 혈액계 질환에는 용혈성 빈혈, 혈소판 감소증, 혈구포식세포 증식증(hemophagocytosis) 등이 있다. 마이코플라즈마 폐렴에서의 냉항체에 의한 자가면역성 용혈로 용혈성 빈혈이 발생할 수 있으며, 이 때 항체의 역가와 용혈의 정도에 상관관계가 있을 수 있다. 저자들은 마이코플라즈마 폐렴에 의해 용혈성 빈혈이 발현된 유전성 구상 적혈구증 1례를 경험하였기에 보고하는 바이다.

Keywords

References

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