Pediatric Infection and Vaccine

  • 제16권1호
  • /
  • Pages.92-96
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  • 2009
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  • 2384-1079(pISSN)
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  • 2384-1087(eISSN)
대한소아감염학회 (The Korean Society of Pediatric Infectious Diseases)
권호 표지

마이코플라즈마 폐렴에 속발한 심근염으로 사망한 소아 1례

A Case of Fatal Myocarditis Associated with Mycoplasma pneumoniae Pneumonia

  • 김대일 (서울대학교 의과대학 소아과학교실) ;
  • 최진형 (서울대학교 의과대학 소아과학교실) ;
  • 조은영 (서울대학교 의과대학 소아과학교실) ;
  • 최영준 (서울대학교 의과대학 소아과학교실) ;
  • 성지연 (서울대학교 의과대학 소아과학교실) ;
  • 양미애 (서울대학교 의과대학 소아과학교실) ;
  • 오지은 (서울대학교 의과대학 소아과학교실) ;
  • 김소희 (서울대학교 의과대학 소아과학교실) ;
  • 이준호 (서울대학교 의과대학 소아과학교실) ;
  • 이진아 (서울대학교 의과대학 소아과학교실) ;
  • 최은화 (서울대학교 의과대학 소아과학교실) ;
  • 이환종 (서울대학교 의과대학 소아과학교실)
  • Kim, Dae Il (Department of Pediatrics, Seoul National University College of Medicine) ;
  • Choi, Jin Hyoung (Department of Pediatrics, Seoul National University College of Medicine) ;
  • Cho, Eun Young (Department of Pediatrics, Seoul National University College of Medicine) ;
  • Choi, Young June (Department of Pediatrics, Seoul National University College of Medicine) ;
  • Sung, Ji Yeon (Department of Pediatrics, Seoul National University College of Medicine) ;
  • Yang, Mi Ae (Department of Pediatrics, Seoul National University College of Medicine) ;
  • Oh, Chi Eun (Department of Pediatrics, Seoul National University College of Medicine) ;
  • Kim, So Hee (Department of Pediatrics, Seoul National University College of Medicine) ;
  • Lee, Jun Ho (Department of Pediatrics, Seoul National University College of Medicine) ;
  • Lee, Jina (Department of Pediatrics, Seoul National University College of Medicine) ;
  • Choi, Eun Hwa (Department of Pediatrics, Seoul National University College of Medicine) ;
  • Lee, Hoan Jong (Department of Pediatrics, Seoul National University College of Medicine)
  • 투고 : 2009.05.19
  • 심사 : 2009.06.01
  • 발행 : 2009.06.25
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초록

Mycoplasma pneumoniae는 소아 및 청소년에게 발병하는 폐렴의 주요한 원인균으로, 중추신경계, 피부나 점막, 소화기계 등의 합병증을 자주 동반하는 것으로 알려져 있다. 하지만 M. pneumoniae와 관련된 심장의 합병증은 비교적 흔하지 않은 것으로 알려져 있고 특히 소아에서는 드문 것 로 알려져 있다. 이에 저자들은 M. pneumoniae 폐렴으로 입원하여 치료 중에 속발한 심근염으로 사망한 47개월 여아에 관한 증례를 보고하는 바이다.

Mycoplasma pneumoniae is a common cause of respiratory tract infections. M. pneumoniae infection frequently manifests with extrapulmonary symptoms such as central nervous system complications, skin or mucosal involvement, and gastrointestinal problems. However, cardiac complications associated with M. pneumoniae are rarely reported. We report the case of a 47-month-old girl who died of fulminant myocarditis associated with M. pneumoniae pneumonia.

키워드

참고문헌

  1. Waites KB, Talkington DF. Mycoplasma pneumoniae and its role as a human pathogen. Clin Microbiol Rev 2004;17:697-728. https://doi.org/10.1128/CMR.17.4.697-728.2004
  2. Sahez-Vargas FM, Gomez-Duarte OG. Mycoplasma pneumoniae -an emerging extra-pulmonary pathogen. Clin Microbiol Infect 2008;14:105-17. https://doi.org/10.1111/j.1469-0691.2007.01834.x
  3. Koskiniemi M. CNS manifestations associated with Mycoplasma pneumoniae infections: summary of cases at the University of Helsinki and review. Clin Infect Dis 1993;17 Suppl 1:S52-7. https://doi.org/10.1093/clinids/17.Supplement_1.S52
  4. Atkinson TP, Balish MF, Waites KB. Epidemiology, clinical manifestations, pathogenesis and laboratory detection of Mycoplasma pneumoniae infections. FEMS Microbiol Rev 2008;32:956-73. https://doi.org/10.1111/j.1574-6976.2008.00129.x
  5. Rottem S. Interaction of mycoplasmas with host cells. Physiol Rev 2003;83:417-32. https://doi.org/10.1152/physrev.00030.2002
  6. Yavlovich A, Tarshis M, Rottem S. Internalization and intracellular survival of Mycoplasma pneumoniae by nonphagocytic cells. FEMS Microbiol Lett 2004;233: 241-6. https://doi.org/10.1111/j.1574-6968.2004.tb09488.x
  7. Paddenberg R, Wulf S, Weber A, Heimann P, Beck LA, Mannherz HG. Internucleosomal DNA fragmentation in cultured cells under conditions reported to induce apoptosis may be caused by mycoplasma endonucleases. Eur J Cell Biol 1996;71:105-19.
  8. Kannan TR, Baseman JB. Hemolytic and hemoxidative activities in Mycoplasma penetrans. Infect Immun 2000; 68:6419-22. https://doi.org/10.1128/IAI.68.11.6419-6422.2000
  9. Paz A, Potasman I. Mycoplasma associated carditis. Case reports and review. Cardiology 2002;97:83-8. https://doi.org/10.1159/000057677
  10. Ponka A. Carditis associated with Mycoplasma pneumoniae infection. Acta Med Scand 1979;206:77-86. https://doi.org/10.1111/j.0954-6820.1979.tb13473.x
  11. Agarwala BN, Ruschhaupt DG. Complete heart block from Mycoplasma pneumoniae infection. Pediatr Cardiol 1991;12:233-6. https://doi.org/10.1007/BF02310573
  12. Ong K, Lai SH, Wee KP. A case of acute necrotizing eosinophilic myocarditis with an associated raised myoplasma serology: an incidental finding or a causal association? Pathology 2008;40:410-3. https://doi.org/10.1080/00313020802036780
  13. Esposito S, Droghetti R, Bosis S, Claut L, Marchisio P, Principi N. Cytokine secretion in children with acute Mycoplasma pneumoniae infection and wheeze. Pediatr Pulmonol 2002;34:122-7. https://doi.org/10.1002/ppul.10139
  14. Somers GR, Smith CR, Wilson GJ, Zielenska M, Tellier R, Taylor GP. Association of drowning and myocarditis in a pediatric population: an autopsy-based study. Arch Pathol Lab Med 2005;129:205-9.
  15. Formosa Gouder M, Bailey M, Barbara C, Muscat C, Grech V. Mycoplasma pneumonia - an unusual cause of acute myocarditis in childhood. Images Paediatr Cardiol 2006;29:7-10.
  16. Kenney RT, Li JS, Clyde WA Jr, Wall TC, O'Connor CM, Campbell PT, et al. Mycoplasmal pericarditis: evidence of invasive disease. Clin Infect Dis 1993;17: S58-62. https://doi.org/10.1093/clinids/17.Supplement_1.S58
  17. Szymanski M, Petric M, Saunders FE, Tellier R. Mycoplasma pneumoniae pericarditis demonstrated by polymerase chain reaction and electron microscopy. Clin Infect Dis 2002;34:E16-7. https://doi.org/10.1086/338158