소아 메티실린내성 황색포도알균 감염증의 임상양상과 치료

Clinical Manifestation and Treatment of Methicillin-resistant Staphylococcus aureus Infections in Children

  • 최은화 (서울대학교 의과대학 소아과학교실)
  • Choi, Eun Hwa (Department of Pediatrics, Seoul National University College of Medicine)
  • 투고 : 2009.05.10
  • 심사 : 2009.06.05
  • 발행 : 2009.06.25

초록

Methicillin-resistant Staphylococcus aureus (MRSA), a leading cause of nosocomial infections, has been increasingly recognized in communities of the United States. This article will review the clinical spectrum and treatment of MRSA infections in children in the context of recent epidemiological changes of MRSA infections. In general, community-associated (CA) MRSA most frequently causes skin and soft tissue infections and has an increased association with invasive infections, particularly pneumonia and musculoskeletal infections. Hospital-associated (HA) MRSA strains tend to be associated with bloodstream infections, pneumonia, and surgical site infections. Different from the United States, CA-MRSA infections are not common in Korea (only 5.9%); however, there are some CA-MRSA clones that are different from HA-MRSA clones in Korea and from CA-MRSA clones in other countries. The treatment of MRSA infections should be guided by antimicrobial susceptibility testing, the site of infection, and the infection severity. Vancomycin is the treatment of choice for invasive MRSA infections. Other agents such as trimethoprim-sulfamethoxazole, clindamycin, linezolid, quinupristin-dalfopristin, and daptomycin have been used for some conditions.

키워드

참고문헌

  1. Benner EJ, Kayser FH. Growing clinical significance of methcillin-resistant Staphylococcus aureus. Lancet 1968;2:741-4.
  2. Kallen AJ, Driscoll TJ, Thornton S, Olson PE, Wallace MR. Increase in community acquired Methicillinresistant Staphylococcus aureus at a Naval Medical Center. Infect Control Hosp Epidemiol 2000;21:223-6. https://doi.org/10.1086/501750
  3. Salmenlinna S, Lyytikainen O, Vuopio-Varkila J. Community- acquired Methicillin-resistant Staphylococcus aureus, Finland. Emerg Infect Dis 2002;8:602-7. https://doi.org/10.3201/eid0806.010313
  4. The National Committee for Clinical Standards. Performance standards for antimicrobial susceptibility testing. 8th information supplement, NCCLS document M100- S14. Wayne (PA): The Committee; 2004.
  5. Kreiswirth B, Kornblum J, Arbeit RD, Eisner W, Maslow JN, McGeer A, et al. Evidence for a clonal origin of methicillin resistance in Staphylococcus aureus. Science 1993;259:227-30. https://doi.org/10.1126/science.8093647
  6. Crisostomo MI, Westh H, Tomasz A, Chung M, Oliveira DC, de Lencastre H. The evolution of methicillin resistance in Staphylococcus aureus: similarity of genetic backgrounds in historically early methicillinsusceptible and -resistant isolates and contemporary epidemic clones. Proc Natl Acad Sci USA 2001;98: 9865-70. https://doi.org/10.1073/pnas.161272898
  7. Enright, MC, Robinson, DA, Randle, G, Feil EJ, Grundmann H, Spratt BG. The evolutionary history of methicillin-resistant Staphylococcus aureus (MRSA). Proc Natl Acad Sci USA 2002;99:7687-92. https://doi.org/10.1073/pnas.122108599
  8. Herold BC, Immergluck LC, Maranan MC, Lauderdale DS, Gaskin RE, Boyle-Vavra S, et al. Communityacquired methicillin-resistant Staphylococcus aureus in children with no identified predisposing risk. JAMA 1998;279:593-8.. https://doi.org/10.1001/jama.279.8.593
  9. Klevens RM, Morrison MA, Nadle J, Petit S, Gershman K, Ray S, et al. Invasive methicillin-resistant Staphylococcus aureus infections in the United States. JAMA 2007;298:1763-71. https://doi.org/10.1001/jama.298.15.1763
  10. Davis, KA, Stewart, JJ, Crouch, HK, Florez CE, Hospenthal DR. Methicillin-resistant Staphylococcus aureus (MRSA) nares colonization at hospital admission and its effect on subsequent MRSA infection. Clin Infect Dis 2004;39:776-82. https://doi.org/10.1086/422997
  11. Thompson RL, Cabezudo I, Wenzel RP. Epidemiology of nosocomial infections caused by methicillin- resistant Staphylococcus aureus. Ann Intern Med 1982;97:309-17. https://doi.org/10.7326/0003-4819-97-3-309
  12. Wisplinghoff H, Bischoff T, Tallent SM, Seifert H, Wenzel RP, Edmond MB. Nosocomial bloodstream infections in US hospitals: Analysis of 24,179 cases from a prospective nationwide surveillance study. Clin Infect Dis 2004;39:309-17. https://doi.org/10.1086/421946
  13. Sader HS, Streit JM, Fritsche TR, Jones RN. Antimicrobial susceptibility of gram-positive bacteria isolated from European medical centres: results of the Daptomycin Surveillance Programme (2002-2004). Clin Microbiol Infect 2006;12:844-52. https://doi.org/10.1111/j.1469-0691.2006.01550.x
  14. Ko KS, Kim YS, Song JH, Yeom JS, Lee H, Jung SI, et al. Genotypic diversity of methicillin-resistant Staphylococcus aureus isolates in Korean hospitals. Antimicrob Agents Chemother 2005;49:3583-5. https://doi.org/10.1128/AAC.49.8.3583-3585.2005
  15. Charlebois ED, Perdreau-Remington F, Kreiswirth B, Bangsberg DR, Ciccarone D, Diep BA, et al. Origins of community strains of methicillin-resistant Staphylococcus aureus. Clin Infect Dis 2004;39:47-54. https://doi.org/10.1086/421090
  16. Naimi TS, LeDell KH, Como-Sabetti K, Borchardt SM, Boxrud DJ, Etienne J, et al. Comparison of community- and health care-associated methicillin-resistant Staphylococcus aureus infection. JAMA 2003; 290:2976-84. https://doi.org/10.1001/jama.290.22.2976
  17. Salgado CD, Farr BM, Calfee DP. Community acquired methicillin-resistant Staphylococcus aureus: a meta-analysis of prevalence and risk factors. Clin Infect Dis 2003;36:131-9. https://doi.org/10.1086/345436
  18. Jeong HY, Jang SJ, Lee SD, Park SH, Chang JY, Min CS, et al. Antibiotic resistance of Staphylococcus aureus isolated from community in Korea. [SL-09] In: Program and abstracts of the 4th International Symposium on Antimicrobial Agents and Resistance (Seoul). Republic of Korea: Asian-Pacific Research Foundation for Infectious Diseases, 2003.
  19. Ma SH, Lee YS, Lee SH, Kim HK, Jin JS, Shin EK, et al. distinct clinical and microbiological features in a Korean community. J Med Microbiol 2007;56:866-8. https://doi.org/10.1099/jmm.0.46962-0
  20. Ko KS, Lee JY, Baek JY, Peck KR, Rhee JY, Kwon KT, et al. Characterization of Staphylococcus aureus nasal carriage from children attending an outpatient clinic in Seoul, Korea. Microb Drug Resist 2008; 14:37-44. https://doi.org/10.1089/mdr.2008.0776
  21. King MD, Humphrey BJ, Wang YF, Kourbatova EV, Ray SM, Blumberg HM. Emergence of community acquired methicillin-resistant Staphylococcus aureus USA 300 clone as the predominant cause of skin and soft-tissue infections. Ann Intern Med 2006;144: 309-17. https://doi.org/10.7326/0003-4819-144-5-200603070-00005
  22. Fridkin, SK, Hageman, JC, Morrison, M, Sanza LT, Como-Sabetti K, Jernigan JA, et al. Methicillinresistant Staphylococcus aureus disease in three communities. N Engl J Med 2005;352:1436-44. https://doi.org/10.1056/NEJMoa043252
  23. Gorwitz, RJ. A review of community-associated methicillin- resistant Staphylococcus aureus skin and soft tissue infections. Pediatr Infect Dis J 2008;27:1-7. https://doi.org/10.1097/INF.0b013e31815819bb
  24. Diederen BM, Kluytmans JA. The emergence of infections with community-associated methicillin resistant Staphylococcus aureus. J Infect 2006;52:157-68. https://doi.org/10.1016/j.jinf.2005.09.001
  25. American Academy of Pediatrics. Staphylococcal infections. In: Red Book: 2006 Report of the Committee on Infectious Diseases, 27th ed, Pickering, LK (Ed), American Academy of Pediatrics, Elk Grove Village, IL 2006. p.598.
  26. Karchmer, AW. Staphylococcus aureus and vancomycin: The sequel. Ann Intern Med 1991;115:739-41. https://doi.org/10.7326/0003-4819-115-9-739