Journal of Pharmaceutical Investigation

The Korean Society of Pharmaceutical Sciences and Technology (한국약제학회)
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Enhanced Topical Delivery of Arbutin using Intense Pulsed Light (IPL)

Intense Pulsed Light(IPL)를 이용한 알부틴의 경피 흡수 개선

  • Choi, Joon-Ho (College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University) ;
  • Chung, Suk-Jae (College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University) ;
  • Shim, Chang-Koo (College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University) ;
  • Kim, Dae-Duk (College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University)
  • Published : 2009.04.27
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Abstract

The objective of this study was to investigate the feasibility of applying the Intense Pulsed Light (IPL) as a tool to enhance the skin absorption of arbutin, a well-known skin-whitening agent. Arbutin solution or skin formulation was applied on the back of hairless mouse skin in vivo after IPL treatment, and then the skin deposition of arbutin was determined by HPLC. IPL treatment significantly increased the amount of arbutin in the skin after 6 hours when arbutin solution was applied 20 times. IPL also enhanced the skin deposition of arbutin when arbutin formulation was applied, although it was not significantly different. Significant increase of surface skin temperature was observed by IPL treatment, which might be a mechanism of the enhanced skin absorption of arbutin. These results suggest the feasibility of using IPL as a tool to increase the skin absorption of whitening agents, although further research needs to be conducted to understand its exact mechanism.

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References

  1. D.K. Hincha, A.E. Oliver and J.H. Crowe, Lipid composition determines the effects of arbutin on the stability of membranes, Biophysical J., 77, 2024-2034 (1999). https://doi.org/10.1016/S0006-3495(99)77043-8
  2. C.S. Yong, J.D. Rhee and H.G. Choi, Factors affecting percutaneous absorption, The J.S.B.R., 2, 49-67 (2000).
  3. J.E. Riviere and M.C. Heit, Electrically-assisted transdermal drug delivery, Pharm. Res., 14, 687-697 (1997). https://doi.org/10.1023/A:1012129801406
  4. R.H. Guy and J. Hadgraft, Transdermal Drug Delivery, Marcel Dekker, New York, U.S.A, 59-81 (1989)
  5. H.A. Ahn, Transdermal delivery of cationic drug, isopropamide through rat skin by iontophoresis, Thesis of Pharm. Seoul Nati. Univ., (1991).
  6. P. Tyle and P. Agrawala, Drug delivery by phonophoresis, Pharmaceutical Research, 6, 355-359 (1989). https://doi.org/10.1023/A:1015967012253
  7. S. Mitragotri, D. Blankschtein and R. langer, Transdermal drug delivery using low-frequency sonophoresis, Pharm. Res., 13, (1996). https://doi.org/10.1023/A:1016096626810
  8. D. Bommannan, H. Okuyama, P. Stauffer and R.H. Guy, Sonophoresis. I. The use of high-frequency ultrasound to enhance transdermal drug delivery, Pharm. Res., 9, 559-564 (1992). https://doi.org/10.1023/A:1015808917491
  9. C. RaulinRaulin, S. Werner, W. Hartschuh and M.P. Schonermark, Effective treatment of hypertrichosis with pulsed light : a report of two cases, Ann. Plast. Surg., 39, 169-173 (1997). https://doi.org/10.1097/00000637-199708000-00009
  10. C.A. Schroeter and H.A. Neumann, An intense light source. The Photoderm VL-flashlamp as a new treatment possibliity for vascular skin lesions, Dermatol. Surg., 24, 743-748 (1998). https://doi.org/10.1016/S1076-0512(97)00505-0
  11. M.P. Goldman, Treatment of benign vascular lesions with the Photoderm VL high-intensity pulsed light source, Adv. Dermatol., 13, 503-521 (1997).
  12. M.H. Gold, T.D. Foster and M.W. Bell, Nevus spilus successfully treated with an intense pulsed light source, Dermatol. Surg., 25, 254-255 (1999). https://doi.org/10.1046/j.1524-4725.1999.08192.x
  13. G.A. Moreno Arias and J. Ferrando, Intense pulsed light for melanocytic lesions, Dermatol. Surg., 27, 397-400 (2001). https://doi.org/10.1046/j.1524-4725.2001.00315.x
  14. J.M. Yarborough, Dermabrasion by wire brush, J. Dermatol. Surg. Oncol., 13, 610-615 (1987). https://doi.org/10.1111/j.1524-4725.1987.tb00526.x
  15. H.M. Heise, L. Kupper and L.N. Butvina, Mid-infrared attenuated total reflection spectroscopy of human stratum corneum using a silver halide fiber probe of square crosssection and adhesive tape stripping, J. Mol. Struct., 661, 281-289 (2003). https://doi.org/10.1016/j.molstruc.2003.07.019
  16. B. Friedrich, D. Michael, H. Ulrich, K. Roland, K. Gerd, K. Wolfgang, L. Michael, N. Reinhard, R. Christian and S. Nikolaus, Recommendations for medical and aesthetic treatment of the skin using laser or intense pulsed light (IPL) systems, Medical Laser Application, 20, 105-114 (2008).
  17. F.N. Craig, E.G. Cummings and V.M. Sim, Environmental temperature and the percutaneous absorption of a cholinesterase inhibitor VX, J. Invest. Dermatol., 68, 357-361 (1977). https://doi.org/10.1111/1523-1747.ep12496487