Korean Journal of Community Nutrition (대한지역사회영양학회지)

The Korean Society of Community Nutrition (대한지역사회영양학회)
권호 표지

Nutritional Status of Zinc and Copper in Type 2 Diabetic Patients after Short-term Zinc Supplementation

제 2형 당뇨병 환자에서 단기간 아연 보충에 따른 아연과 구리 영양상태

  • Oh, Hyun-Mee (Department of Food and Nutrition, Keimyung University) ;
  • Yoon, Jin-Sook (Department of Food and Nutrition, Keimyung University)
  • Published : 2009.04.30
Download PDF
⟨ Previous Next ⟩

Abstract

This study was carried out to determine whether a short-term zinc supplementation could improve the zinc status without adverse changes in copper status among type 2 diabetic patients. Seventy-six diabetic subjects and 72 normal adults participated in this study. Subjects were randomly divided into supplemented and control groups. Forty-four diabetic patients and 34 normal subjects were supplemented with 50 mg zinc gluconate daily for 4 weeks. Dietary intakes of participants were measured for two non-consecutive days by 24-hour recall method. Nutritional status of zinc and copper were also evaluated by biochemical measurement of fasting plasma samples and spot urinary collection. At baseline, diabetic patients showed significantly lower levels of dietary zinc intake and higher urinary zinc excretion than the normal adult group(p<0.05, p<0.0001). Plasma level of zinc was not significantly different between diabetic and normal adults at baseline. However, plasma zinc level increased significantly in both diabetic patients and normal adults after zinc supplementation. The changes in plasma copper levels following zinc supplementation were not statistically significant in diabetic subjects as well as in normal adults. These results indicated that four weeks of zinc supplementation did not influence Cu status and that it may contribute to improving the zinc status. Therefore, we suggest that Zn supplementation for a short-term period may improve marginal zinc status of diabetic patients without interfering with their copper status

Keywords

References

  1. Anderson RA, Roussel AM, Zouari N, Mahjoub S, Matheau JM & Kerkeni A (2001): Potential antioxidant effects of zinc and chromium supplementation in people with type 2 diabetes mellitus. J Am Coll Nutr 20(3): 212-218
  2. Baynes JW (1991): Role of oxidative stress in development of complications in Diabetes. Diabetes 40(4): 405-412 https://doi.org/10.2337/diabetes.40.4.405
  3. Bonham M, O'Connor JM, Alexander HD, Coulter J, Walsh PM, McAnena LB, Downes CS, Hannigan BM & Strain JJ (2003): Zinc supplementation has no effect on circulating levels of peripheral blood leucocytes and lymphocyte subsets in healthy adult men. Br J Nutr 89(5): 695-703 https://doi.org/10.1079/BJN2003826
  4. Bray TM, Bettger WJ (1990): The physiological role of zinc as an antioxidant. Free Radic Biol Med 8(3): 281-291 https://doi.org/10.1016/0891-5849(90)90076-U
  5. Castillo-Duran C, Heresi G, Fisberg M, Uauy R (1987): Controlled trial of zinc supplementation during recovery from malnutrition : effects on growth and immune function Am J Clin Nutr 45(3): 602-608
  6. Chandra RK (1984): Excessive intake of zinc impairs immune responses J Am Med Assoc 252(11): 1443-1446 https://doi.org/10.1001/jama.252.11.1443
  7. Chausmer AB (1998): Zinc, Insulin and Diabetes J Am Coll Nutr 17(2): 109-115
  8. Chyun JH, Choi YJ (1996): Dietary copper intakes and effect of zinc supplementation on plasma copper level in Korean adults Korean J Nutr 29(5): 528-532
  9. Cunningham JJ, Fu A, Mearkle PL, Brown RG (1994):Hyperzincuria in individuals with Insulin-Dependent diabetesmellitus : concurrent zinc status and the effect of high-dose zincsupplementation Metablism 43(12):1568-1562 https://doi.org/10.1016/0026-0495(94)90018-3
  10. Cusins RJ (1985): Absortion, transport, and hepatic metabolism of copper and zin : Special reference to metallothionein and ceruloplasma. Physiol Rev 65(2): 238-309
  11. Davis CD, Milne DB, Nielsen FH (2000): Changes in dietary zinc and copper affect zinc-status indicators of postmenopausal women, notably, extracellular superoxide dismutase and amyloid precursor proteins. Am J Clin Nutr 71(3): 781-788
  12. Disilvestro RA (2000): Zinc in relation to diabetes and oxidative disease. J Nutr 130(5S): 1509S-1511S
  13. Faure P, Roussel A, Coudray C, Richard MJ, Halimi S, Favier A (1992): Zinc and insulin sensitivity Biol Trace Elem Res 32:305-310 https://doi.org/10.1007/BF02784615
  14. Gatto LM, Samman S (1995): the effect of zinc supplementation on plasma lipids and low-density lipoprotein oxidation in males Free Radical Biol & Med 19(4): 517-521 https://doi.org/10.1016/0891-5849(95)00041-U
  15. Golik A, Cohen N, Ramot Y, Maor J, Moses R, Weissgarten J, Leonov Y, Modai D (1993): Type II diabetes mellitus, congestive heart failure, and zinc metabolism Biol Trace Elem Res 39(2):171-175 https://doi.org/10.1007/BF02783187
  16. Hawk PB, Oser BL, Summerson WH (1954): Practical physiology chemistry 13th ed pp 899, Blakiston Co Inc, Toronto
  17. King JC, Keen CL (1994): Modern nutrition in health and disease,pp. 214-230, Lea & Febiger, Malvern
  18. Korean Food Research Institute (1998): Handbook of Portion Size for Food Intake Research, Seoul
  19. Lee JH, Lee HJ, Lee IK& Yoon JS (2005): Zinc and copper status of middle- and old-aged woman in type 2 diabetes. Korean J Nutr38(1): 56-66
  20. Levine AS, McClain CJ, Handwerger BS, Brown DM, Morley JE(1983): Tissue zinc status of genetically diabetic and streptozotocin-induced diabetic mice. Am J Clin Nutr 37(3):382-386
  21. Marchesini G, Bugianesi E, Ronchi M, Flamia R, Thomaseth K & Pacini G (1998): Zinc supplementation improves glucose disposal in patients with cirrhosis. Metabolism 47(7):792-798 https://doi.org/10.1016/S0026-0495(98)90114-7
  22. Maxwell SR, Thompson H, Sandler D, Leguen C, Baxter MA, Thorpe GHG, Jones AF, Barnett AH (1997): Antioxidant status in patients with uncomplicated insulin-dependent and noninsulin- dependent diabetes mellitus. Eur J Clin Invest 27(6):484-490 https://doi.org/10.1046/j.1365-2362.1997.1390687.x
  23. Milne DB, Davis CD, Nielsen FH (2001): Low dietary zinc alters indices of copper function and status in postmenopausal women, Nutr 17(9): 701-708 https://doi.org/10.1016/S0899-9007(01)00560-3
  24. Niewoehner CB, Allen JI, Boosalis M, Levine AS & Morley JE(1986): Role of zinc supplementation in type II diabetes mellitus,Am J Med 81(1): 63 https://doi.org/10.1016/0002-9343(86)90183-X
  25. Oh HM & Yoon JS (2008): Glycemic control of type 2 diabetic patients after short-term Zinc supplementation. Nutr Res Practice 2(4):283-288 https://doi.org/10.4162/nrp.2008.2.4.283
  26. Percival SS (1995): Neutropenia caused by copper deficiency :possible mechanisms of action, Nutr Rev 53(3): 59-66 https://doi.org/10.1111/j.1753-4887.1995.tb01503.x
  27. Roussel AM, Kerkeni A, Zouari N, Mahjoub S, Matheau JM & Anderson RA (2003): Antioxidant effects of zinc supplementation in Tunisians with type 2 diabetes mellitus, J Am Coll Nutr 22(4):316-321
  28. Salgueiro MJ, Krebs N, Zubillaga MB, Weill R, Postaire E, Lysionek AE, Caro RA, Paoli TD, Hager A & Boccio J (2001): Zinc and Diabetes Mellitus. Is there a need of zinc supplementation in diabetes mellitus patients? Biol Trace Elem Res 81(3): 215-228 https://doi.org/10.1385/BTER:81:3:215
  29. Sandstrom B (2001): Micronutrient interactions : effects on absorption and bioavailability. Br J Nutr 85(2):181-185 https://doi.org/10.1079/BJN2000312
  30. Sazawal S, Black BE, Bhan MK, Jalla S, Bhandari N, Sinhha A, Majumdar S (1996): Zinc supplementation reduces the incidence of persistent diarrhea and dysentery among low socioeconomic children in India. J Nutr 126(2): 443-450
  31. The Korean Nutrition Society (2005): Dietary Reference intakes for Koreans
  32. Thomson KH, Godin DV (1995): Micronutrients and antioxidants in the progression of diabetes, Nutr Res 15(9):1377-1410 https://doi.org/10.1016/0271-5317(95)02012-K
  33. Turnlund J (1988): Copper nutriture, bioavailability, and the influence of dietary factors. J Am Diet Assoc 88(3):303-308