Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
권호 표지

Analysis of Volatile Components of the Musk of Ondatra zibethicus by Gas Chromatography-Mass Spectrometry

가스크로마토그래피-질량분석기를 이용한 서사향의 향기성분 분석

  • Jin, Yong-Xie (Department of Food Science and Nutrition, College of Natural Science, Hallym University) ;
  • Choi, Se-Jin (Department of Food Science and Nutrition, College of Natural Science, Hallym University) ;
  • Jung, Eui-Jin (Department of Food Science and Nutrition, College of Natural Science, Hallym University) ;
  • Kim, Sun-Ju (Department of Biological Environment and Chemistry, College of Agriculture and Life Sciences, Chungnam National University) ;
  • Jeon, Young-Eun (Department of Food Science and Nutrition, College of Natural Science, Hallym University) ;
  • Kang, Il-Jun (Department of Food Science and Nutrition, College of Natural Science, Hallym University) ;
  • Chung, Cha-Kwon (Department of Food Science and Nutrition, College of Natural Science, Hallym University) ;
  • Lim, Soon-Sung (Department of Food Science and Nutrition, College of Natural Science, Hallym University)
  • 김영섭 (한림대학교 식품영양학과) ;
  • 최세진 (한림대학교 식품영양학과) ;
  • 정의진 (한림대학교 식품영양학과) ;
  • 김선주 (충남대학교 생물환경화학) ;
  • 전영은 (한림대학교 식품영양학과) ;
  • 강일준 (한림대학교 식품영양학과) ;
  • 정차권 (한림대학교 식품영양학과) ;
  • 임순성 (한림대학교 식품영양학과)
  • Published : 2009.12.31
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Abstract

Essential oils of the musk from wild muskrat (Ondatra zibethicus) were analyzed by gas chromatography/mass spectrometry. Fifty-six chemical components were separated, and 14 volatile compounds (78% of composition of total essential oil) of macrocyclic musk, mainly cyclopentadecanone, 12-hydroxy-14-methyl-oxa-cyclotetradec-6-en-2-one, cycloheptadecanone and 9-cycloheptadecen-1-one, were identified by the comparison of Wiley/NBS Library from the results of GC-MS. However, l-muscone, a compound reported by earlier workers in the musk from muskrat, was not detected using the spike test in this study. Interestingly, cyclohexadecanone, which has the same molecular weight (Mw 238) as l-muscone, was identified. In addition, it is considered that because of possessing much higher amounts of macrocyclic components compared to the original musk, muskrat has higher economic values in perfume and pharmaceutical industries.

Keywords

References

  1. 김재길. (1984) 천연약물대사전. 남산당, p345
  2. 吴晋, 孙星衍, 孙馮翼, 梅彪. (1985) 神農本草經，北京 中華書局
  3. Cho, T. S., Kim, N. D., Huh, I. H., Kwon, K. I., Park, S. K., Shim, S. H., Shin, D. H. and Park, D. K. (1997) Pharmacological Actions of l-Muscone on Cardiovascular System. J. Appl. Pharmacol. 5(3): 299-305
  4. Chen, W. K., Huang, Y. F. and Wang, H. D. (2004) An experimental study on distribution of musk into the brain through blood brain barrier. J. Chin. Integr. Med. 2(4): 288-291 https://doi.org/10.3736/jcim20040417
  5. Schmeiser, H. H., Gminski, R. and Sundermann, V.M. (2001) Evaluation of health risks caused by musk ketone. Int. J. Hyg. Environ. Health. 203: 293-299 https://doi.org/10.1078/1438-4639-00047
  6. Choi, E. W., Kim, K. N., Shin, S. D., Cho, M. H. and Mar, W. C. (2000) The comparative effects of Civet-containing and musk-containing Woohwangchungwon on the Central Nervous System. Yakhak Hoeji. 44(5): 470-477
  7. Chen, Y. S. and Wei, H. J. (2002) A New resources of Natural Animal Perfume Studies on Muskrat Perfume Product in Muskrats. Flav. Frag. Cosmetics. 5: 12-16
  8. Sokolov, V. E., Kagan, M. Z., Vasilieva, V. S., Prihodko, V. I. and Zinkevich, E. P. (1987) Musk Deer: Reinvestigation of main lipid components from preputial gland secretion. J. Chem. Ecol. 13(1): 71-83 https://doi.org/10.1007/BF01020352
  9. Kweon, O. K., Sung, H. J., Kwack, H. L., Fang, M. Z., Shin, D. H., Lee, J. Y., Park, D. K., Chung, K. H., Yoon, H. I. and Cho, M. H. (1998) Acute and subacute toxicity of new woohwangchungsimwon in beagle dogs. J. Toxicol. Pub. Health. 14(2): 249-260
  10. Li, Y. B., Xu, S. L. and Deng, D. (2001) 서사향의 독성연구. Heilongjiang J. Anim. Sci. and Vet. Med. 10: 33-34
  11. Gao, J.T., Yao, Y., Wang, W.M., Tang, H.l. and Liu,Y.M. (2000) Anti-inflammation and anti-coagulation effects of the muskrat musk. Heilongjiang med. pharm. 23(6): 9-10
  12. Chen, X. Z., Qiu, Z. D., Zhang, Y. H. and Zhang, H. (2005) Comparison of anti-inflammation and analgesia between muskrat and moschus. Journal of Jilin University. 31(3): 414-416
  13. Chen, J. X., Liu, Z. Q., Song, F. R. and Liu, S. Y. (1998) Analysis of Chemical Constitutes in Lipid From Musk-Rat Musk by Gas Chromatography/Mass Spectrometry. Chinese J. Anal. Chem. 26(9): 1142-1145
  14. Van Dorp. (1973) New macrocycle compounds for the secretions of the civet cat and the muskrat${\L}$$\AE$Recuei. 92: 9-15
  15. Li, B. T., Li, C. S., Sun, F. J., Zhang, L. X. and Song, F. R. (1994) Determination of chemical composition of muskrat musk. Chinese Pharm. J. 29(7): 396-397
  16. Hu, B. G., Liang, Z. B. and Wei, J. X. (1992) 사향, 영묘향, 서사향 중 Macrocyclic성분의 분리와 분석. Agriculture & Technology. 6: 39-41
  17. Mou, J., Yu, Y. Q., Yang, Y. H., Wang, W. J., Chen, J. X. and Shun, Y. Q. (1999) 서사향 분비물의 유효성분인macrocyclic 화합물의 분석연구. Inspection and Quarantine Science. 9(3): 41-45
  18. Wang, L. H. (1999) 인공채취 서사향의 화학성분 및 약리활성연구. Special Wild Economic Animal and Plant Research. 3: 56-60