대한한의학방제학회지 (Herbal Formula Science)

  • 제17권2호
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  • Pages.175-186
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  • 2009
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  • 1229-1218(pISSN)
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  • 2288-5641(eISSN)
대한한의학방제학회 (The Korean Medicine Society for the Herbal Formula Study)
권호 표지

담죽엽 추출물의 혈관이완 기전에 대한 연구

Effect of Lophatherum gracile on the mechanism of vasorelaxation in thoracic aorta

  • 김혜윰 (원광대학교 한의학전문대학원) ;
  • 리향 (원광대학교 한의학전문대학원) ;
  • 이윤정 (원광대학교 한의학전문대학원) ;
  • 서환호 (원광대학교 한의과대학 침구학교실) ;
  • 조남근 (원광대학교 한의과대학 침구학교실) ;
  • 강대길 (원광대학교 한의학전문대학원) ;
  • 이호섭 (원광대학교 한의학전문대학원)
  • Kim, Hye-Yoom (Professional Graduate School of Oriental Medicine, College of Oriental Medicine, Wonkwang University) ;
  • Li, Xiang (Professional Graduate School of Oriental Medicine, College of Oriental Medicine, Wonkwang University) ;
  • Lee, Yun-Jeong (Professional Graduate School of Oriental Medicine, College of Oriental Medicine, Wonkwang University) ;
  • Seo, Hwan-Ho (Dept. of Acupuncture and Moxibustion, College of Oriental Medicine, Wonkwang University) ;
  • Cho, Nam-Geun (Dept. of Acupuncture and Moxibustion, College of Oriental Medicine, Wonkwang University) ;
  • Kang, Dae-Gill (Professional Graduate School of Oriental Medicine, College of Oriental Medicine, Wonkwang University) ;
  • Lee, Ho-Sub (Professional Graduate School of Oriental Medicine, College of Oriental Medicine, Wonkwang University)
  • 발행 : 2009.12.30
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초록

The vasorelaxant effect of an extract of Lophatherum gracile Brongn (ELB) and its possible action mechanism were ascertained in aortic tissues isolated from rats. ELB relaxed endothelium-intact thoracic aorta in a dose-dependent manner. However, the induced vascular relaxation was abolished by removal in endothelium of the thoracic aorta. Pretreatment of endothelium-intact vascular tissues with $N^G$-nitro-L-arginine methyl ester (L-NAME) or 1H-[1,2,4]-oxadiazole-[4,3-$\alpha$]-quinoxalin-1-one (ODQ) significantly inhibited vascular relaxation induced by ELB. Moreover, ELB significantly increased cGMP production in aortic tissues, which was blocked by pretreatment with L-NAME or ODQ. The vasorelaxant effect of ELB was attenuated by tetraethylammonium (TEA), and glibenclamide. ELB-induced vasorelaxation was not blocked by atropine, propranolol, indomethacin, verapamil, and diltiazem. Taken together, the present study demonstrates that ELB dilates vascular smooth muscle via an endothelium-dependent NO-cGMP signaling pathway, which may be at least in part related with the function of $K^+$ channels.

키워드

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