대한본초학회지 (The Korea Journal of Herbology)

  • 제24권4호
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  • Pages.107-113
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  • 2009
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  • 1229-1765(pISSN)
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  • 2288-7199(eISSN)
대한본초학회 (The Korea Association of Herbology)
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배발효 음료가 천식이 유발된 생쥐의 기도 과민성 및 면역 글로불린 분비에 미치는 영향

Effects of Pear Alcoholic Fermentation Beverage on Airway Hyperresponsiveness and Immunoglobulin Production in Asthmatic Mice

  • 정영민 (부산대학교 한의학전문대학원) ;
  • 김형우 (부산대학교 한의학전문대학원) ;
  • 정희진 (부산대학교 한의학전문대학원) ;
  • 최유진 (부산대학교 한의학전문대학원) ;
  • 도윤호 (동신대학교 친환경농식품산업화센터) ;
  • 최정식 (동신대학교 친환경농식품산업화센터) ;
  • 조수인 (부산대학교 한의학전문대학원)
  • Joung, Young-Min (School of Oriental Medicine, Pusan National University) ;
  • Kim, Hyung-Woo (School of Oriental Medicine, Pusan National University) ;
  • Chung, Hee-Jin (School of Oriental Medicine, Pusan National University) ;
  • Choi, Eu-Gene (School of Oriental Medicine, Pusan National University) ;
  • Do, Yoon-Ho (Center for Organic Agri-Food Industrialization, Dongshin University) ;
  • Choi, Jeong-Sik (Center for Organic Agri-Food Industrialization, Dongshin University) ;
  • Cho, Su-In (School of Oriental Medicine, Pusan National University)
  • 발행 : 2009.12.30
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초록

Objectives : This study was designed to investigate the effects of alcoholic fermentation beverage using pear, Bae Ro Mi In (BRMI) on airway hyperresponsiveness and immunoglobulin production in asthmatic mice Methods : We investigated the effects of BRMI on airway hyperresponsiveness by measurement of enhanced pause (Penh), and also investigated the effects on production levels of antigen specific antibody and subclasses such as IgG1, IgG2a and IgE by using ELISA methods. Prednisolone (PD, 5 mg/kg) was used as positive control. Results : Treatment with BRMI did not lowered airway hyperresponsiveness, but PD lowered significantly. Oral administration of BRMI lowered production level of ovalbumin (OVA) specific total antibody significantly. Especially, BRMI decreased IgE levels compared to non-treated control effectively. Treatment with PD lowered production levels of total antibody, IgG1 and IgE. Conclusions : These result suggest that BRMI can lower production levels of antigen specific total antibody and IgE in asthmatic mice. We also suggest that BRMI has the possibility to prevent or cure asthma through regulation of antigen specific antibody production.

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참고문헌

  1. Kao ST, Wang SD, Wang JY, Yu CK, Lei HY. The effect of Chinese herbal medicine, xiao-qinglong tang (XQLT ), on allergen-induced bronchial inflammation in mite-sensitized mice. Allergy. 2000 ; 55 : 1127-33. https://doi.org/10.1034/j.1398-9995.2000.00728.x
  2. Kurt J Lsselbacher et al. Harrison's principles of internal medicine. 13th ed. Seoul : Jung Dam. 1997 : 1258.
  3. Sugita M, Kuribayashi K, Nakagomi T, Miyata S, Matsuyama T, Kitada O. Allergic bronchial asthma: airway inflammation and hyperresponsiveness. Intern Med. 2003 ; 42(8) : 636-43. https://doi.org/10.2169/internalmedicine.42.636
  4. Maezawa Y, Nakajima H, Kumano K, Kubo S, Karasuyama H, Iwamoto I. Role of IgE in Th2 cell-mediated allergic airway inflammation. Int Arch Allergy Immunol. 2003 ; 131 : 2-6. https://doi.org/10.1159/000070473
  5. Leynadier F, Lambin P, Murrieta M, Dry J. Blocking antibodies to inhalant allergens and asthma. Allerg Immunol. 1991 ; 23(8) : 341-7.
  6. 陣貴廷. 本草綱目通釋. 北京 : 學苑出版社 1992 : 1449-50.
  7. 나창수, 정종길, 윤대환. 배(梨) 추출 Phenolic Compound 및 길경(桔梗) 행인(杏仁) 배합 투여가 Ovalbumin으로 유발된 천식 동물 모델에서 기관지평활근 장력, 호산구 및 IL-4에 미치는 영향. 대한본초학회지. 2007 ; 22(2) : 25-33.
  8. 나창수, 윤대환, 최동희, 정종길, 은종방, 김정상. 배에서 추출된 Pextin과 Phenolic compound가 흰쥐의 국소뇌혈류 및 심혈관계에 미치는 영향. 대한본초학회지. 2003 ; 18(2) : 101-8.
  9. 나창수, 윤대환, 최동희, 김정상, 조춘화, 은종방. 배추출 펙틴이 2KIC 고혈압 흰쥐의 혈압, 혈장 Renin, ANP 및 Cardiac Hypertrophy에 미치는 영향. 한국식품영양과학회지. 2003 ; 32(5) : 700-5.
  10. 김정상, 나창수. 생지황과 배의 Phenolic Compound가 Streptozotocin으로 유발된 고혈당 생쥐에 미치는 영향. 한국식품영양과학회지. 2004 ; 33(1) : 66-71.
  11. Lee JC, Pak SC, Lee SH, Na CS, Lim SC, Song CH, Bai YH, Jang CH. Asian pear pectin administration during pre-sensitization inhibits allergic response to ovalbumin in BALB/C mice. J Altern Complement Med. 2004 ; 10(3) : 527-34. https://doi.org/10.1089/1075553041323867
  12. 나창수, 윤대환, 정종길. 배(梨) 추출 Phenolic Compound 및 길경(桔梗) 행인(杏仁) 배합 투여가 Ovalbumin으로 유발된 천식 동물 모델에서 기관지 평활근 장력, 호산구 및 IL-4에 미치는 영향. 대한본초학회지. 2007 ; 22(2) : 25-33.
  13. 안봉전, 이진태, 곽재훈, 박정미, 이진영, 손준호, 배종호, 최청. 한국산 배과피 폴리페놀 분획군의 생리활성효과. 한국응용생명화학회지. 2004 ; 47(1) :92-5.
  14. 김형우, 김경윤, 김병주, 강수우, 도윤호, 남내이, 정현우, 최정식, 조수인. 배의 씨방 및 과피의 알콜 발효 추출물이 피부에 미치는 영향. 대한본초학회지. 2009 ; 24(1) : 133-9.
  15. 김창민, 신민교, 안덕균, 이경순 외. 중약대사전. 서울 : 정담. 1997 : 3452.
  16. Corry DB, Folkesson HG, Warnock ML, Erle DJ, Matthay MA, Wiener- Kronish JP, Locksley RM. Interleukin 4, but not interleukin 5 or eosinophils, is required in a murine model of acute airway hyperreactivity. J Exp Med. 1996 ; 183(1) : 109- 17. https://doi.org/10.1084/jem.183.1.109
  17. 이숙영, 송정섭, 김영균, 김관형, 문화식, 박성학. 기관지 천식의 기도과민 반응과 기관지폐포세척액 소견. 대한내과학회지. 1995 ; 48(2) : 171-80.
  18. Barnes PL. A new approach to the treatment of asthman. Engl J Med. 1989 ; 321 : 1517. https://doi.org/10.1056/NEJM198911303212206
  19. O'Byrne PM, Walters EH, Gold BD, Aizawa HA, Fabbri LM, Alpert SE, Nadel JA, Holtzman MJ. Neutrophil depletion inhibits airway hyperresponsiveness induced by ozone exposure. Am Rev Respir Dis. 1984 ; 130(2) : 214-9.
  20. Murphy KR, Wilson MC, Irvin CG, Glezen LS, Marsh WR, Haslett C, Henson PM, Larsen GL. The requirement for polymorphonuclear leukocytes in the late asthmatic response and heightened airways reactivity in an animal model. Am Rev Respir Dis. 1986 ; 134(1) : 62-8.
  21. Cho SJ, Kim HW, Kim BY, Cho SI. Sam So Eum, a herb extract, as the remedy for allergen-induced asthma in mice. Pulm Pharmacol Ther. 2008 ; 21(3) : 578-83. https://doi.org/10.1016/j.pupt.2008.02.001
  22. Sziksz E, Kozma GT, Pallinger E, Komlosi ZI, Adori C, Kovács L, Szebeni B, Rusai K, Losonczy G, Szabo A, Vannay A. Galectin-9 in Allergic Airway Inflammation and Hyper-Responsiveness in Mice. Int Arch Allergy Immunol. 2009 ; 151(4) : 308-17. https://doi.org/10.1159/000250439
  23. 윤호주. 기관지천식의 치료원칙. Tuberculosis and Respiratory Diseases. 2006 ; 60(6) : 601-7. https://doi.org/10.4046/trd.2006.60.6.601
  24. Visser MJ, van der Veer E, Postma DS, Arends LR, de Vries TW, Brand PL et al. Side-effects of fluticasone in asthmatic children: no effects after dose reduction. Eur Respir J. 2004 ; 24 : 420-5. https://doi.org/10.1183/09031936.04.00023904
  25. Gea-Banacloche JC, Opal SM, Jorgensen J, Carcillo JA, Sepkowitz KA, Cordonnier C. Sepsis associated with immunosuppressive medications: an evidence-based review. Crit Care Med. 2004 ; 32 : 578-90. https://doi.org/10.1097/01.CCM.0000143020.27340.FF
  26. Eid N, Morton R, Olds B, Clark P, Sheikh S, Looney S. Decreased morning serum cortisol levels in children with asthma treated with inhaled fluticasone propionate. Pediatrics. 2002 ; 109 : 217-21. https://doi.org/10.1542/peds.109.2.217
  27. Wen MC, Wei CH, Hu ZQ, Srivastava K, Ko J, Xi ST et al. Efficacy and tolerability of anti-asthma herbal medicine intervention in adult patients with moderate-severe allergic asthma. J Allergy Clin Immunol. 2005 ; 116 : 517-24. https://doi.org/10.1016/j.jaci.2005.05.029
  28. Lynch EL, Little FF, Wilson KC, Center DM, Cruikshank WW. Immuno-modulatory cytokines in asthmatic inflammation. Cytokine Growth Factor Rev. 2003 ; 14(6) : 489-502. https://doi.org/10.1016/S1359-6101(03)00056-X
  29. Nagao K, Akabane H, Masuda T, Komai M, Tanaka H, Nagai H. Effect of MX-68 on airway inflammation and hyperresponsive -ness in mice and guinea-pigs. J Pharm Pharmacol. 2004 ; 56 : 187-96. https://doi.org/10.1211/0022357022548
  30. Barnes PJ. Immunomodulation as asthma therapy: where do we stand? Eur Respir J Suppl. 1996 ; 22 : 154-9.