The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
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Effects of Black Ginseng on Hypertension-induced Rats

흑삼이 폐고혈압 유발 흰쥐에 미치는 영향

  • Song, Nak-Keun (Department of Pathology, College of Oriental Medicine, Daejeon University) ;
  • Choi, Hak-Ju (Department of Pathology, College of Oriental Medicine, Daejeon University) ;
  • Kim, Dong-Hee (Department of Pathology, College of Oriental Medicine, Daejeon University) ;
  • Roh, Seong-Soo (Laboratory of Herbology, College of Oriental Medicine, Daegu Haany University) ;
  • Seo, Young-Bae (Department of Herbalogy, College of Oriental Medicine, Daejeon University)
  • 송낙근 (대전대학교 한의과대학 병리학교실) ;
  • 최학주 (대전대학교 한의과대학 병리학교실) ;
  • 김동희 (대전대학교 한의과대학 병리학교실) ;
  • 노성수 (대구한의대학교 한의과대학 본초학연구실) ;
  • 서영배 (대전대학교 한의과대학 본초학교실)
  • Published : 2009.12.30
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Abstract

Objectives : To access the safety and efficacy of Black Ginseng (BG), a traditional herbal medicine on hypertension, we examined various parameters involved in the pathogenesis of hypertension. Methods : We made deoxycorticosterone acetate (DOCA;25 mg/kg/3times/weeks for 3 weeks)-induced hypertension Sprague-Dawley (SD) rats. And experiment group was treated with extract of black ginseng (BG;200 mg/kg/day). Results : In results, the weight of experiment group treated with BG was increased compared with normal and control group. And the heart and lung weights of experiment group were decreased compared with control group. The blood pressure and pulse rate of group treated with BG were significantly decreased compared with control group. In addition, BG greatly reduced the levels of aldosterone. These results suggested that BG has suppressive effects on hypertension, and BG has potential as a safe and effective therapeutics for hypertension. Conclusions : The present data show evidences on anti-hypertension activity of BG in an experimental animal system, which can provide further insights into the development of anti-hypertension therapeutic agents.

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References

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