The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
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Effect of Buddleja officinalis in Diabetic Atherosclerotic Mouse Model Using High Fat Diet

고지방 식이로 유도된 당뇨병성 죽상경화 마우스 모델에서 밀몽화의 효능 연구

  • Hwang, Sun-Mi (Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Lee, Yun-Jung (Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Kim, Eun-Ju (Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Kim, Hye-Yoom (Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Li, Xiang (Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Choi, Yong-Jun (Department of Acupuncture & Moxibustion, College of Oriental Medicine, Wonkwang University) ;
  • Cho, Nam-Geun (Department of Acupuncture & Moxibustion, College of Oriental Medicine, Wonkwang University) ;
  • Lee, Ho-Sub (Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Kang, Dae-Gill (Professional Graduate School of Oriental Medicine, Wonkwang University)
  • 황선미 (원광대학교 한의학전문대학원) ;
  • 이윤정 (원광대학교 한의학전문대학원) ;
  • 김은주 (원광대학교 한의학전문대학원) ;
  • 김혜윰 (원광대학교 한의학전문대학원) ;
  • 리향 (원광대학교 한의학전문대학원) ;
  • 최용준 (원광대학교 한의과대학 침구학교실) ;
  • 조남근 (원광대학교 한의과대학 침구학교실) ;
  • 이호섭 (원광대학교 한의학전문대학원) ;
  • 강대길 (원광대학교 한의학전문대학원)
  • Published : 2009.12.30
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Abstract

Objectives : This study was designed to investigate the effects of an aqueous extract from Buddleja officinalis Maxim (ABO) on vascular dysfunction in low-density lipoprotein receptor deficient (LDLr KO) mice. Methods : Present study showed that LDLr KO mice were fed a high fat diet consisting of 60 kcal% fat, with or without 200 mg/day/kg ABO of diet, for 14 weeks. Results : High fat diet-LDLr KO mice were treated with ABO were completely normalized by lowering glucose. ABO reduced intima/media thickness in a high fat diet-LDLr KO mice without affecting plasma cholesterol and triglyceride levels. ABO caused endothelium-dependent relaxation in the acetylcholine-precontracted aorta of high fat diet-LDLr KO mice. ABO increased eNOS expression, while decreased cell adhesion molecules expression in high fat diet-LDLr KO mice. Conclusions : In conclusion, chronic treatment with ABO improved hyperglycemia and endothelium-dependent vascular relaxation as well as exhibited anti-inflammatory effect in diabetic atherosclerotic mouse model, independent of effects on plasma lipids.

Keywords

References

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