A Study on the Relationship between Sasang Constitution and Framingham Coronary Risk Score

사상체질(四象體質)과 Framingham Coronary Risk Score의 상관성(相關性)에 관한 연구(硏究)

  • Shim, Gyue-Hearn (Dept. of Sasang Constitutional Medicine College of Oriental Medicine, Sangji University) ;
  • Yoo, Jun-Sang (Dept. of Sasang Constitutional Medicine College of Oriental Medicine, Sangji University) ;
  • Koh, Sang-Baek (Dept. of Preventive Medicien Wonju College of Medicine, Yonsei University) ;
  • Park, Jong-Ku (Dept. of Preventive Medicien Wonju College of Medicine, Yonsei University)
  • 심규헌 (상지대학교 한의과대학) ;
  • 유준상 (상지대학교 한의과대학) ;
  • 고상백 (연세대학교 원주의과대학 예방의학교실) ;
  • 박종구 (연세대학교 원주의과대학 예방의학교실)
  • Published : 2009.04.30

Abstract

1. Objectives This study was designed to research the relationship between Sasang Constitution and Framingham coronary risk score(FRS), 2. Methods 666 people, over 40 years old, were participated in the community-based cohort in Wonju, South Korea from July 2nd to August 30th in 2006, Sasang Constitutional Diagnosis was carried out using PSSC(Phonetic System of Sasang Constitution), face and tongue photos and a checkup list, Framingham coronary risk score(FRS) was calculated using previously studied sheets adopted from KCDC(Korea Center for Disease Control and Prevention). 3. Results The average FRS of men was 7,06 and that of female was 8,19 which was significantly higher than that of men. There were significant differences between Taeeumin and other constitutions in women, whereas no differences among male constitutions. Analyzing adjusted ORs for CHD risk intervals according to Sasang constitution, they were 0.96 in Taeeumin and 1.70 in Soyangin to Soeumin. Also 0.55 in Taeeumin and 3.39 in Soyangin to Soeumin in men, 1.96 in Taeeumin and 1.87 in Soyangin to Soeumin in women. Women had highet FRS than men and female Taeeumin group have highet FRS points and CRP than other constitutions. 4. Conclusions Regarding the positive relationship between FRS, APG and CRP, it is thought to be useful to understand APG and CRP results at the same time when calculating FRS. When it comes to prevention and screening of CHD, female Taeeumin should be more careful and female Soyangin also should have a consideration of heart disease.

Keywords

References

  1. McGovern PG, Pankow JS, Shahar E, Doliszny KM, Folsom AR, Blackburn H, Luepker RV, the Minesota Heart Survey Investigators. Recent trends in acute coronary heart disease: Mortality, morbidity, medical care, and risk factors. N Engl J Med 1996;334:884-890. https://doi.org/10.1056/NEJM199604043341403
  2. 통계청. 2005년 사망원인 통계. Available from http://kosis.nso.go.kr
  3. 미국립보건원(NIH) 산하 국립심폐혈액연구원 (NHLBI) Available from http://www.nhlbi.nih.gov
  4. Andrew Beswick, Peter Brindle. Risk Scoring in the Assessment of Cardiovascular Risk, Current Opinion in Lipidology 2006;17: 375-386. https://doi.org/10.1097/01.mol.0000236362.56216.44
  5. Wilson PW, D'Agostino RB, Levy D, Belanger AM, Silbersharz H, Kannel WB. Prediction of coronary heart disease using risk factor categories. Circulation 1998;97: 1837-1847. https://doi.org/10.1161/01.CIR.97.18.1837
  6. Expert Pannel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Summary of the third report of the National Cholesterol Education Progtacn(NCEP) Expert Pannel on Detection, Evaluation, and Treatment of High Blood Cholestetol in Adults (Adult Treatment Pannel Ill). JAMA. 2001;285:2486-2497. https://doi.org/10.1001/jama.285.19.2486
  7. Pearson TA New tools for coronary risk assessment: What are their advantages and limitations? Circulation 2002;105: 886-892. https://doi.org/10.1161/hc0702.103727
  8. Ridker PM, Rifai N, Clearfield M, Downs JR, Weis SE, Miles JS. Measurement of C-reactive protein for the targeting of statintherapy in the primary prevention of acute coronary events. NEngl J Med. 2001;344:1959 -1965. https://doi.org/10.1056/NEJM200106283442601
  9. Danesh J, Whincup P, Walker M, Lennon L, Thomas A, Appleby P, Gallimore JR, Pepys MB. Low grade inflmmation and coronary heart disease: Prospective study and updated meta-analyses. BMJ. 2000;321: 199-204. https://doi.org/10.1136/bmj.321.7255.199
  10. Philip Greenlan, Jonathan Abrams, Gerard P. Aurigemma et al. Prevention Conference V; Beyond Secondary Prevention: Identifying the High-Risk Patient for Primary Prevention Noninvasive Tests of Atherosclerotic Burden. Circulation 2000;101:e16-e22. https://doi.org/10.1161/01.CIR.101.1.e16
  11. 김영조. Framingham 관상동맥 위험 점수와 C-반응성 단백의 연관성. 영남대학교 대학원 석사논문, 2004
  12. Sonia S. Anand, Fahad Razak, Qilong Yi, Bonnie Davis, Ruby Jacobs, VIad Vuksan, Eva Lonn, Koon Teo, Matthew McQueen, Salim Yusuf. C-Reactive Protein as a Screening Test for Cardiovascular Risk in a Multiethnic Population. Arterioscler Thromb Vasc Biol. 22004;24:1509-1515. https://doi.org/10.1161/01.ATV.0000135845.95890.4e
  13. Luiz A Bortolotto, Jacques Blacher, Takeshi Kondo, Kenji Takazawa, Michel E. Safar. Assessment of Vasucular Aging and Atherosclerosis in Hypertensive Subjects: Second Derivative of Photoplethysmogram Versus Pulse Wave Velocity. American Journal of Hypertension. 2000; 13: 165-171. https://doi.org/10.1016/S0895-7061(99)00192-2
  14. Kenji Takazawa, Nobuhiro Tanaka, Masami Fujita, Osamu Matsuoka, Tokuyu Saiki, Masaru Aikawa, Sinobu Tamura, Chiharu Ibukiyarna. Assessment of Vasoactive Agents and Vascular Aging by the Second Derivative of Photoplethysmogram Waveform. Hypertension 1998;32:365-370. https://doi.org/10.1161/01.HYP.32.2.365
  15. Taylor AJ, Burke AP, O'Malley PG, Farb A, Malcom GT, Smialek J, Virmani R. A comparison of the Framingham risk index, coronary artery calcification, and culprit plaque morphology in sudden cardiac death. Circulation 2000; 101: 1243-1248. https://doi.org/10.1161/01.CIR.101.11.1243
  16. Cobb FR, Kraus WE, Root M, Allen JD. Assessing risk for coronary heart disease: beyond Framingham. Am Heart J. 2003; 146:572-580. https://doi.org/10.1016/S0002-8703(03)00500-3
  17. 송일병 외 16 인. 사상의학. 집문당, 발행지 2004:164.
  18. 이태규, 황민우, 이수경, 최봉근, 고병희, 송일병. 사상체질에 따른 대사증후군의 유병률과 위험인자에 대한 연구. 대한한의학회지. 2006;27(2): 14-22
  19. JP Empana, P Ducimetiere, D Arveiler, J Ferrieres, A Evans, JB Ruidavets, B Haas, J Yarnell, A Bingham, P Amouyel, J Dallongeville, on behalf of the PRIME Study Group. Are the Framingham and PROCAM coronary heart disease risk functions applicable to different European populations? European Heart Journal. 2003;24:1903-1911. https://doi.org/10.1016/j.ehj.2003.09.002
  20. Jialal I, Devaraj S. Inflammation, and atherosclerosis: The value of the high sensitive C-reactive protein assay as a marker. Am J Clin pathol. 2001;116:S108-115.
  21. Ledue TB, Rifai N. Preanalytic and analytic sources of variations in C-reactive protein measurement: Implications for cardiovascular disease risk assessment. Clin Chem. 2003;49: 1258-1271. https://doi.org/10.1373/49.8.1258
  22. Tracy RP. Inflammation markers and coronary heart disease. Curr Opin Lipidol. 1999;10:435-551. https://doi.org/10.1097/00041433-199910000-00008
  23. Pearson TA, Mensah GA, Alexander RW, Anderson JL, Cannon RO Ill, Criqui M. Markers of inflammation and cardiovascular disease: Appliation to clinical and public health practice: A starement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association. Circulation. 2003;107:499-511. https://doi.org/10.1161/01.CIR.0000052939.59093.45
  24. Ridker PM, Hennekens CH, Buring JE, Rifai N. C-reactive protein and other markers of inflammation in the prediction of coronary artery disease in women. N Engl J Med. 2000; 342:836-843. https://doi.org/10.1056/NEJM200003233421202
  25. Ridker PM, Rifai N, Rose L, Buring JE, Cook NR Comparison of C-reactive protein and low density lipoprotein cholesterol levels in the prediction of first cardiovascular events. N Engl J Med. 2002;347: 1557-1565. https://doi.org/10.1056/NEJMoa021993
  26. Ridker PM, Cuslunan M, Stampfer MJ, Tracy RP, Hennekens CH. Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men. N Engl J Med. 1997;336:973-979. https://doi.org/10.1056/NEJM199704033361401
  27. Ballantyne CM, Hoogeveen RC, Bang HJ, Coresh J, Folsom AR, Heiss G, Sharrett AR Lipoprotein-associated phospholipase A2, high-snsitivity C-reactive protein, and risk for incident coronary heart disease in middle-aged men and women in the Atherosclerosis Risk in Communities(ARIC) Srudy. Circulation. 2004;109:837-842. https://doi.org/10.1161/01.CIR.0000116763.91992.F1
  28. Van der Meer I, de Maat MP, Kiliaan AJ, van der Kuip DA, Hofman A, Witteman JC. The value of C-reactive protein in cardiovascular risk prediction: the Rotterdam Study. Arch Intern Med. 2003;163: 1323-1328. https://doi.org/10.1001/archinte.163.11.1323