Korean Journal of Acupuncture

Society for Meridian and Acupoint (경락경혈학회)
권호 표지

Anti-inflammatory Effect of Dianthi Semen Herbal-acupuncture at KI10 on nephritis in rats

음곡에 시술한 구맥 약침이 LPS로 유도된 흰쥐의 신장염에 미치는 영향

  • Kim, Kyung-Min (Dept. of Acupoint & Meridian, Oriental Medicine College, Daejeon University) ;
  • Lee, Hyun (Acupuncture & Moxibution, Oriental Medicine College, Daejeon University) ;
  • Kang, Hee-Jung (Daeyomedi Co., Ltd.) ;
  • Lee, Yong-Heum (Dept. of Biomedical Engineering, College of Health Science, Yonsei University) ;
  • Yim, Yun-Kyoung (Dept. of Acupoint & Meridian, Oriental Medicine College, Daejeon University)
  • 김경민 (대전대학교 한의과대학 경락경혈학교실) ;
  • 이현 (대전대학교 한의과대학 침구학교실) ;
  • 강희정 (대요메디(주)) ;
  • 이용흠 (연세대학교 보건과학대학 의공학과 한의공학연구실) ;
  • 임윤경 (대전대학교 한의과대학 경락경혈학교실)
  • Published : 2009.03.27
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Abstract

Objective : This study aimed to evaluate the effects of Dianthi Semen Herba herbal-acupuncture (DS-HA) at KI10 (Umgok) on nephritis induced by LPS in rat. Methods : Rats were injected with LPS and treated with DS-HA at KI10 3 times for a week(DS-HA), N.P. group was treated 26 gauge needle at KI10, saline group was treated with normal saline at KI10. To estimate the effects of DS-HA at KI10 on nephritis in rats, WBC, neutrophils in blood, BUN, creatinine TNF-${\alpha}$, CINC-1 in serum, urinal volume and creatinean and total protein in urine, reanl TNF-${\alpha}$, renal MPO were measured and histological analysis of renal tissue was performed. Results : DS-HA at KI10 significantly decreased WBC and neutrophil in blood and BUN and creatinin in serum, MPO in kidney, and significantly increased urinary volume in LPS-stimulated rats. DS-HA at KI10 reduced accumulation of neutrophil in renal tissue of LPS-stimulated rats. Conclusions : Taken together, DS-HA at KI10 has a protective or therapeutic effect for nephritis in LPS-stimulated rat. Therefore, it is suggested that DS-HA at KI10 may be an useful therapeutics in clinical field after further researches.

Keywords

References

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