Molecular & Cellular Toxicology

The Korean Society of Toxicogenomics and Toxicoproteomics (대한독성유전 단백체학회)
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The Food Safety of Superfine Saengshik Processed by Top-down Technique in Mice

  • Kim, Dong-Heui (Department of Environmental Medical Biology, Wonju College of Medicine, Yonsei University) ;
  • Song, Soon-Bong (Department of Environmental Medical Biology, Wonju College of Medicine, Yonsei University) ;
  • Qi, Xu-Feng (Department of Environmental Medical Biology, Wonju College of Medicine, Yonsei University) ;
  • Kang, Wie-Soo (Department of Plant Biotechnology, School of Bioscience and Biotechnology, Kangwon National University) ;
  • Jeong, Yeon-Ho (Department of Molecular and Medical Biotechnology, School of Biotechnology, Kangwon National University) ;
  • Teng, Yung-Chien (Department of Environmental Medical Biology, Wonju College of Medicine, Yonsei University) ;
  • Lee, Seon-Goo (Department of Pathology, College of Oriental Medicine, Sangji University) ;
  • Kim, Soo-Ki (Department of Microbiology, Wonju College of Medicine, Yonsei University) ;
  • Lee, Kyu-Jae (Department of Environmental Medical Biology, Wonju College of Medicine, Yonsei University)
  • Published : 2009.03.31
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Abstract

Saengshik is an uncooked and powdered functional food composed of various edible plants, and has been consumed widely due to its health benefits and convenient uptake. Recently, superfine ground saengshik, which contains a certain extent of nanoscale particles, has been commercialized to enhance efficacy, but its safety has not been determined. This study was conducted to evaluate the food safety of superfine saengshik (SS) through general toxicity examination after oral uptake in mice compared to conventional fine saengshik (FS). The SS particle size distribution was 0.479-26.303 f.1m in diameter, with about 68.92% of particles with a diameter < $0.955{\mu}m$. From our safety evaluation, the number of white blood cells (WBCs) and biochemical values in the serum fell into the normal range, and the weight of organs showed no significant difference between FS and SS groups. Histological observation of the liver, small intestine and large intestine did not show any abnormal or pathological findings under light microscopy. Our results suggest that oral intake of SS is not harmful to mice in terms of general toxicity.

Keywords

References

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