대한한의학회지 (The Journal of Korean Medicine)

  • 제30권2호
  • /
  • Pages.79-87
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  • 2009
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  • 1010-0695(pISSN)
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  • 2288-3339(eISSN)
대한한의학회 (The Society of Korean Medicine)
권호 표지

타액침전물모델을 이용한 청구감로수 구성약물의 구취억제작용

Inhibitory Effect of Respective Herbs in Cheonggugamrosu on Oral Malodor Using Malodor Modeling of the Salivary Sediment System

  • 김진성 (경희대학교 한의과대학 비계내과학교실) ;
  • 박재우 (경희대학교 한의과대학 비계내과학교실) ;
  • 윤성우 (경희대학교 한의과대학 비계내과학교실) ;
  • 류봉하 (경희대학교 한의과대학 비계내과학교실)
  • Kim, Jin-Sung (Department of Internal Medicine, College of Oriental Medicine, Kyung Hee University) ;
  • Park, Jae-Woo (Department of Internal Medicine, College of Oriental Medicine, Kyung Hee University) ;
  • Yoon, Seong-Woo (Department of Internal Medicine, College of Oriental Medicine, Kyung Hee University) ;
  • Ryu, Bong-Ha (Department of Internal Medicine, College of Oriental Medicine, Kyung Hee University)
  • 발행 : 2009.03.31
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초록

Objective: This study assessed five respective herbs in Cheonggugamrosu (CGGRS) for ability to inhibit malodor in vitro. Methods: We used malodor modeling of the salivary sediment system. Incubation mixtures were prepared with sediment at 16.7% (v/v), amino acids (cysteine and tryptophan) at 6mM and either herb extract at 1% (w/v) or water as control. Mixtures were incubated at $37^{\circ}C$ and odor was monitored organoleptically and for volatile sulfur compounds with the Halimeter. Indole/skatole was determined by Kovac's colorimetric method. Results: Two of the herbs, Caryophilli Flos and Glycyrrhizae Radix, had inhibitory effect on malodor generation. Both of them significantly reduced VSC, organoleptic odor and indole/skatole formation (p<0.05). Conclusions: We found Caryophilli Flos and Glycyrrhizae Radix played a main role in CGGRS. Both herbs have potential as effective anti-malodor agents and this suggests they are worthy of further exploration.

키워드

참고문헌

  1. Attia EL, Marshall KG. Halitosis. Can Med Assoc J. 1982;126:1281-5.
  2. Rosenberg M. Bad breath: diagnosis and treatment. Univ Toronto Dent J. 1990;3(2):7-11.
  3. Waler SM. On the transformation of sulfurcontaining amino acids and peptides to volatile sulfur compounds (VSC) in the human mouth. Eur J Oral Sci. 1997;105:534-7. https://doi.org/10.1111/j.1600-0722.1997.tb00241.x
  4. Krespi YP, Shrime MG, Kacker A. The relationship between oral malodor and volatile sulfur compoundproducing bacteria. Otolaryngol Head Neck Surg. 2006;135(5):671-6. https://doi.org/10.1016/j.otohns.2005.09.036
  5. Goldberg S, Kozlovsky A, Gordon D, Gelernter I, Sintov A, Rosenberg M. Cadaverine as a putative component of oral malodor. J Dent Res. 1994;73(6):1168-72
  6. Flotra L. Side effects of chlorohexidine mouth washes. Scan J Dent Res. 1971;79:119-25.
  7. Rule KL, Ebbett VR, Vikes PJ. Formation of chloroform and chlorinated organics by freechlorine- mediated oxidation of triclosan. Environ Sci Technol. 2005;39:3176-85. https://doi.org/10.1021/es048943+
  8. Sim SY, Kim KJ. Literary Study on Halitosis. J East Med. 2000;4(1): 86-104.
  9. Eom GH, Kim JS. Deodorizing effect of Cheonggugamrosu. Korean J Orient Int Med. 2007;28 (2):354-62.
  10. Tonzetich J. Production and origin of oral malodor: a review of mechanisms and methods of analysis. Journal of eriodontology. 1977;48:13-20. https://doi.org/10.1902/jop.1977.48.1.13
  11. Yaegaki K, Coil JM. Examination, classification and treatment of halitosis; cinical perspectives. J Can Dent Assoc. 2000;66:257-61.
  12. Park JH, Han KS, Kim MK. Effect of tongue scraping, Zncl2 mouth rinse, and periodontal treatment on the reduction of oral malodor. Kor J Oral Med. 2000;25(1):41-51.
  13. Jung SH, Bae KH, Moon HS, Paik DI, Kim JB, Park DY. Effects of mouth spray containing GFSe, tea extract and UDCA on antimicrobial effect of Streptococcus mutans, reducing of oral malodor and reduction of gingivitis. J Kor Acad Dent Health. 1998;22(1):37-46.
  14. Bae KH, Lee BJ, Jang YK, Lee BR, Lee WJ, Chang DS, Moon HS, Paik DI, Kim JB. The effect of mouthrinse products containing sodium fluoride, cetylpyridinium chloride(CPC), pine leaf extracts and green tea extracts on the plaque, gingivitis, dental caries and halitosis. J Kor Acad Dent Health. 2001;25(1):51-9.
  15. Kim JS, Hong JH, Park JW, Jeon WH, Kim JS, Yun SH, Ryu BH, Ryu KW. The effect of several herbs on reducing halitosis and the comparison of efficacy with EUNDAN and GARGLIN. J Oriental Chr Dis. 2001;7(1):1-8.
  16. Lee JH, Kim ME, Kim KS, Kim SB. Study on development of mouth rinse containing herbal extracts. Kor J Oral Med. 2003;28(1):1-9.
  17. Kida K, Suzuki M, Takagaki A, Nanjo F. Deodorizing effects of tea catechins on amines and ammonia. Biosci Biotechnol Biochem. 2002;66 (2):373-7. https://doi.org/10.1271/bbb.66.373
  18. Choi IW, Kim SR, Jung CH, Park MW. Measurements of deodorizing activities of the beverage formulated with green tea extract, champignon extract and cyclodextrin. Food Sci Biotechnol. 2004;13(3):318-22.
  19. Greenberg M, Urnezis P, Tian M. Compressed mints and chewing gum containing magnolia bark extract are effective against bacteria responsible for oral malodor. J Agric Food Chem. 2007; 55(23):9465-9. https://doi.org/10.1021/jf072122h
  20. YG Hyung, SS Rno, YS Joo. Review on treatment method of Stomatitis(구창), Oral malodor(구취), Oral sweet sense(구감), errosive oral mucous(구미), Dry mouth(구건). Korean Journal of Oriental Medical Ophthalmolony & Otolaryngology & Dermatology. 1997;10(1):50-90.
  21. 허준. 동의보감. 서울:남산당; 1983, 245-6.
  22. 한의과대학 본초학 편집위원회. 본초학. 서울:영림사; 2004, 386-7, 685-6, 586-8, 336-7, 179-80, 170-1.
  23. 생약학교재편찬위원회. 생약학. 서울:동명사; 2005. 362-3, 424-6, 458-61, 348-50, 351-2, 303-5.
  24. Kleinberg I, Codipilly M. Modeling of the oral malodor system and methods of analysis. Quintessence Int. 1999;30:357-69.
  25. Tonzetich J, Carpenter PAW. Production of volatile sulphur compounds from cysteine, cystineand methionine by human dental plaque. Arch Oral Biol. 1971;15:599-607
  26. Rosenberg M, Septon I, Eli I, Bar-Ness R, Gelernter I, Brenner S, Gabbay J. Halitosis measurement by an industrial sulphide monitor. J Periodontol. 1991;62(8):487-9. https://doi.org/10.1902/jop.1991.62.8.487
  27. Gadebusch HH, Gabriel S. Modified stable Kovac's reagent for the detection of indole. Am J Clin Pathol. 1956;26:1373-75.
  28. Codipilly DP, Kaufman HW, Kleinberg I. Use of a novel group of oral malodor measurements to evaluate an anti-oral malodor mouthrinse (Tri- OralTM) in humans. J Clin Dent. 2004;15(4): 98-104.