Progress in Medical Physics (한국의학물리학회지:의학물리)

Korean Society of Medical Physics (한국의학물리학회)
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Comparison of F-18 FDG Radioacitivity to Determine Accurate Dose Calibrator Activity Measurements

방사능 측정기를 이용한 F-18 FDG 방사능의 비교

  • Jin, Gye-Hwan (Department of Radiologic Science, Nambu University) ;
  • Kweon, Dae-Cheol (Department of Radiologic Science, Shinheung College University) ;
  • Oh, Ki-Baek (Department of Nuclear Medicine, Severance Hospital, Yonsei University Medical Center) ;
  • Park, Hoon-Hee (Department of Nuclear Medicine, Severance Hospital, Yonsei University Medical Center) ;
  • Kim, Jung-Yul (Department of Nuclear Medicine, Severance Hospital, Yonsei University Medical Center) ;
  • Park, Min-Soo (Department of Nuclear Medicine, Severance Hospital, Yonsei University Medical Center) ;
  • Park, Dae-Sung (Heart Research Center, Chonnam National University Hospital)
  • 진계환 (남부대학교 방사선학과) ;
  • 권대철 (신흥대학 방사선과) ;
  • 오기백 (연세의료원 세브란스병원 핵의학과) ;
  • 박훈희 (연세의료원 세브란스병원 핵의학과) ;
  • 김정열 (연세의료원 세브란스병원 핵의학과) ;
  • 박민수 (연세의료원 세브란스병원 핵의학과) ;
  • 박대성 (전남대학교병원 심장질환 치료기술 개발 특성화 연구센터)
  • Published : 2009.09.30
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Abstract

Obviously, the administration of the prescribed amount of activity to the patient requires proper operation of the dose calibrator, which shall be verified by implementing the required quality control on the instrument. This investigation examined the accuracy and precision of dose calibrator activity measurement of the radiopharmaceutical F-18 FDG. To investigate the status of the nuclear medicine centers in Korea for the performance of dose calibrators, 10 centers providing PET/CT system services in Korea were inspected in 2008. We measured accuracy and precision in 10 equipments in consideration of PET/CT model, installation area, and installation time. According to the results of comparative analysis of 10 dose calibrators used to measure radioactivity of F-18 FDG, accuracy was -5.00~4.50% and precision was 0.05~0.45%, satisfying the international standards, which are accuracy ${\pm}$10% and precision ${\pm}$5%. This study demonstrated that, for accurate measurements, no adjustment is necessary for a dose calibrator setting when measuring different dose calibrators of F-18 FDG activity prescriptions.

국내병원에 설치된 PET와 PET/CT의 영상품질관리와 방사능 피폭을 효과적으로 관리하기 위해서는 환자에게 투여하는 F-18 FDG 방사능 측정에 사용하는 방사능 측정기에 따른 정도관리가 필요하다. F-18 FDG의 정확도와 정밀도를 방사능 측정기로 방사능을 측정하기 위해 시료제조 및 방사능을 측정하였다. F-18 FDG의 방사능 측정에 사용하는 방사능 측정기의 정확도와 정밀도를 파악하여 방사능 측정기에서 측정한 방사능을 보정하였다. 국내 의료기관의 PET 시스템 10대를 시간간격으로 측정하여 한국표준과학원에서 측정한 방사능을 기준 값으로 병원에서 측정한 방사능과 비교하여 정확도와 정밀도를 산출하였다. 정확도를 이용하여 팬텀에 주입하는 방사능을 보정함으로써 팬텀에 주입하는 방사능량에 대한 신뢰성을 확보하였다. F-18 FDG의 방사능 측정기의 정확도는 -5.00%에서 +4.50%, 정밀도 0.05%에서 0.45%으로 국제기준인 정확도 ${\pm}$10%, 정밀도 ${\pm}$5%를 모두 만족하였다. PET/CT 시스템들에 대한 정량적 비교 분석 자료는 PET/CT의 진단율을 높이는 효과가 기대된다.

Keywords

References

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