Journal of Environmental Science International (한국환경과학회지)

The Korean Environmental Sciences Society (한국환경과학회)
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Effects of Ore Minerals on the Damages of Animal Cells

광물성 미네랄이 동물세포의 손상에 미치는 효과

  • Jeon, Yu-Mi (Department of medical biotechnology, SoonChunHyang University) ;
  • Kim, Jum-Ji (Department of medical biotechnology, SoonChunHyang University) ;
  • Lee, Mi-Young (Department of medical biotechnology, SoonChunHyang University)
  • 전유미 (순천향대학교 의료생명공학과) ;
  • 김점지 (순천향대학교 의료생명공학과) ;
  • 이미영 (순천향대학교 의료생명공학과)
  • Published : 2009.12.31
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Abstract

In this study, we investigated the suppressive effects of ore minerals on the allergic cell damages and oxidative cell damages. The ore minerals significantly reduced the productions of tumor necrosis factor-alpha (TNF-${\alpha}$) and interleukin-4 (IL-4) in rat basophilic leukemia cells challenged with 2,4-dinitrophenol-bovine serum albumin (DNP-BSA). Lipoxygenase activity was also reduced by the ore minerals. Moreover, the ore minerals showed weak protective effects on the oxidative damage induced by hydrogen peroxide in pig kidney cells and retinal ganglion cells. Photohemolysis of erythrocytes in the presence of rose-bengal as a sensitizer was also inhibited by ore minerals. These results suggest that the ore minerals may be useful as the protectant for allergic and oxidative cell damages.

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References

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