Biomedical Science Letters (대한의생명과학회지)

The Korean Society for Biomedical Laboratory Sciences (대한의생명과학회)
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Association of Hepatocyte Nuclear Factor-$4{\alpha}$ (HNF-$4{\alpha}$) Polymorphisms (rs1884614) with Type 2 Diabetes in Korean Population

  • Kim, Su-Won (Department of Biology, College of Natural Sciences, Keimyung University) ;
  • Yoo, Min (Department of Biology, College of Natural Sciences, Keimyung University)
  • ;
  • 유민 (계명대학교 자연과학대학 생물학과)
  • Published : 2009.03.31
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Abstract

The hepatocyte nuclear factor-$4{\alpha}$ (HNF-$4{\alpha}$), transcription factor involved in the regulation of serum lipid and glucose levels, has recently been reported to be associated with type 2 diabetes. Therefore, we investigated the genotype for the rs1884614 of HNF-$4{\alpha}$ gene in Korean population and compared genotype of patients with control group. 100 patients (Male 63, Female 37), who previously underwent type 2 diabetes (T2DM) and 100 controls (Male 36, Female 64) participated in this study. According to our present study there was no association between rs1884614 polymorphism in HNF-$4{\alpha}$ gene and T2DM in Koreans although other reports showed that HNF-$4{\alpha}$ polymorphisms might be associated with the pathogenesis of T2DM in Pima Indians et al. We assume that this finding should contribute to understanding of type 2 diabetes in Korean population in detail at genetic level.

Keywords

References

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