Microbiology and Biotechnology Letters (한국미생물·생명공학회지)

The Korean Society for Microbiology and Biotechnology (한국미생물·생명공학회)
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Biosafety of the New Soft Contact Lens Materials in the Fibroblast L-929 Cell Line

흰쥐의 섬유아세포 L-929를 이용한 새로운 Soft Contact Lens 소재의 생물안전성 검증

  • 유영현 (경북대학교 자연과학대학 생명공학부) ;
  • 남주형 (경북대학교 자연과학대학 생명공학부) ;
  • 김병길 (경북대학교 자연과학대학 생명공학부) ;
  • 김순복 ((주)미광콘택트렌즈) ;
  • 문익재 ((주)웰진) ;
  • 김종필 ((주)웰진) ;
  • 서영배 (경북대학교 자연과학대학 생명공학부)
  • Published : 2009.03.28
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Abstract

In this study, we polymerized new materials for soft contact lens using HEMA (2-hydroxyethyl methacrylate) which is the based-monomer of soft contact lens, EGDMA (ethylene glycol dimethacrylate) as cross linkage agent, and the new additives of monoester or di-ester derived from itaconic acid commercially produced by the fermentation of Asp. itaconicus. New polymer materials for soft contact lens were synthesized with the mixture of HEMA and mono- or diester at different ratios and presented to a good water content and oxygen transmissibility (Dk/L) values. In case of polymerization with HEMA and mono-ester (15%), the water content and oxygen transmissibility of contact lens were found to be good values at 57.6% and 28.5 Dk respectively. The mixture of HEMA and mono-ester is more excellent than HEMA/di-ester in the water content and oxygen transmissibility. The toxicity of new contact lens materials were confirmed in the fibroblast L-929 cell line using a agar overlay test and a growth inhibition test with the extract solution of contact lens.

Keywords

References

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