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Explaining Cancer Incidence in the Jejudo Population

제주도 암발생 양상에 관한 가설 제기 및 규명

  • Bae, Jong-Myon (Department of Preventive Medicine, Cheju National University College of Medicine)
  • 배종면 (제주대학교 의과대학 예방의학교실)
  • Published : 2009.01.31

Abstract

Objectives : Using the population-based cancer registry in Jejudo, we found that Jejudo had lower incidence in stomach cancer than other regions in Korea. The aim of this study was to evaluate reasons for this difference. Methods : Citrus is the leading agricultural production in Jejudo, suggesting that lower cancer incidence in Jejudo could be explained by citrus fruit intake. We evaluated this hypothesis with quantitative systematic review(QSR). Results : Stomach cancer incidence was significantly lower, with a summary odds ratio(SOR) after QSR of 0.72 [95% CI=0.64-0.81]. In addition, the SOR of pancreatic cancer tended to be lower at 0.83 [95% CI=0.70-0.98]. The SOR of prostate cancer was slightly higher at 1.03 [0.89-1.19]. Conclusions : Quantitative systematic reviews for the effect of citrus fruit intake on cancer occurrence suggested that lower cancer incidence in Jejudo could be explained by intake of citrus fruits.

Keywords

References

  1. Hiatt RA, Rimer BK. A new strategy for cancer control research. Cancer Epidemiol Biomarkers Prev 1999; 8(11): 957-964
  2. Kabuto M, Nitta H, Yamamoto S, Yamaguchi N, Akiba S, Honda Y, et al. Childhood leukemia and magnetic fields in Japan: A case-control study of childhood leukemia and residential power-frequency magnetic fields in Japan. Int J Cancer 2006; 119(3): 643-650 https://doi.org/10.1002/ijc.21374
  3. Yang YJ, Bae JM. Survival rates of the 5 major cancers in Jeju Island residents, 2000-2001. J Prev Med Public Health 2007; 40(3): 213-217. (Korean) https://doi.org/10.3961/jpmph.2007.40.3.213
  4. Curado MP, Edwards B, Shin HR, Storm H, Ferlay J, Heanue M, et al, editors. Cancer incidence in five continents, vol. IX. IARC Scientific Publication No. 160. Lyon: IARC; 2007
  5. The community of population-based regional cancer registries in Korea: An estimation of the national cancer incidence in Korea for 2000-2002 using the databases of 8 population-based regional cancer registries. J Prev Med Public Health 2008; 41(6): 380-386. (Korean) https://doi.org/10.3961/jpmph.2008.41.6.380
  6. DeVita VT, Hellman S, Rosenberg SA. Cancer: Principles and Practice of Oncology. 7th ed. Philadelphia: Lippincott Williams & Wilkins; 2005. p.910
  7. Korea Health Industry Development Institute. 2001 Report of Korea National Health and Nutrition Survey. [cited 2008 Dec 10]. Available from: URL:http://knhanes.cdc.go.kr. (Korean)
  8. Yim JY, Kim N, Choi SH, Kim YS, Cho KR, Kim SS, et al. Seroprevalence of Helicobacter pylori in South Korea. Helicobacter 2007; 12(4): 333-340 https://doi.org/10.1111/j.1523-5378.2007.00504.x
  9. Stewart BW, Kleihues P. World Cancer Report. Lyon: WHO IARC Press; 2003. p.83-88
  10. Armstrong B, Doll R. Environmental factors and cancer incidence and mortality in different countries, with special reference to dietary practices. Int J Cancer 1975; 15(4): 617-631 https://doi.org/10.1002/ijc.2910150411
  11. Ziegler RG. A review of epidemiologic evidence that carotenoids reduce the risk of cancer. J Nutr 1989; 119(1): 116-122 https://doi.org/10.1093/jn/119.1.116
  12. Mayne ST, Graham S, Zheng TZ. Dietary retinol: Prevention or promotion of carcinogenesis in humans? Cancer Causes Control 1991; 2(6): 443-450 https://doi.org/10.1007/BF00054305
  13. Byers T, Perry G. Dietary carotenes, vitamin C, and vitamin E as protective antioxidants in human cancers. Annu Rev Nutr 1992; 12: 139-159 https://doi.org/10.1146/annurev.nu.12.070192.001035
  14. van Popple G. Carotenoids and cancer: An update with emphasis on human intervention studies. Eur J Cancer 1993; 29A(9): 1335-1344 https://doi.org/10.1016/0959-8049(93)90087-V
  15. Steinmetz KA, Potter JD. Vegetables, fruit, and cancer: I. Epidemiology. Cancer Causes Control 1991; 2(5): 325-357 https://doi.org/10.1007/BF00051672
  16. Block G, Patterson B, Subar A. Fruit, vegetables, and cancer prevention: A review of the epidemiological evidence. Nutr Cancer 1992; 18(1): 1-29 https://doi.org/10.1080/01635589209514201
  17. Choices for good health: American cancer society guidelines for nutrition and physical activity for cancer prevention. CA Cancer J Clin 2006; 56(5): 310-312 https://doi.org/10.3322/canjclin.56.5.310
  18. Chug-Ahuja JK, Holden JM, Forman MR, Mangels AR, Beecher GR, Lanza E. The development and application of a carotenoid database for fruits, vegetables, and selected multicomponent foods. J Am Diet Assoc 1993; 93(3): 318-323 https://doi.org/10.1016/0002-8223(93)91559-9
  19. Di Mascio P, Kaiser S, Sies H. Lycopene as the most efficient biological carotenoid singlet oxygen quencher. Arch Biochem Biophys 1989; 274(2): 532-538 https://doi.org/10.1016/0003-9861(89)90467-0
  20. Di Mascio P, Murphy ME, Sies H. Antioxidant defense systems: The role of carotenoids, tocopherols, and thiols. Am J Clin Nutr 1991; 53(1 Suppl): 194S-200S https://doi.org/10.1093/ajcn/53.1.194S
  21. Halliwell B, Gutteridge JM, Cross CE. Free radicals, antioxidants, and human disease: Where are we now? J Lab Clin Med 1992; 119(6): 598-620
  22. Ames BN, Shigenaga MK, Hagen TM. Oxidants, antioxidants, and the degenerative diseases of aging. Proc Natl Acad Sci USA 1993; 90(17): 7915-7922 https://doi.org/10.1073/pnas.90.17.7915
  23. Wiseman H, Halliwell B. Damage to DNA by reactive oxygen and nitrogen species: Role in inflammatory disease and progression to cancer. Biochem J 1996; 313(Pt 1): 17-29
  24. Palozza P. Prooxidant actions of carotenoids in biologic systems. Nutr Rev 1998; 56(9): 257-265 https://doi.org/10.1111/j.1753-4887.1998.tb01762.x
  25. Federico A, Morgillo F, Tuccillo C, Ciardiello F, Loguercio C. Chronic inflammation and oxidative stress in human carcinogenesis. Int J Cancer 2007; 121(11): 2381-2386 https://doi.org/10.1002/ijc.23192
  26. World Cancer Research Fund, American Institute for Cancer Research. Food, Nutrition, Physical Activity, and the Prevention of Cancer: A Global Perspective. Washington DC: American Institute for Cancer Research; 2007. p.37-46
  27. Campbell DR, Gross MD, Martini MC, Grandits GA, Slavin JL, Potter JD. Plasma carotenoids as biomarkers of vegetable and fruit intake. Cancer Epidemiol Biomarkers Prev 1994; 3(6): 493-500
  28. Peto R, Doll R, Buckley JD, Sporn MB. Can dietary beta-carotene materially reduce human cancer rates? Nature 1981; 290(5803): 201-208 https://doi.org/10.1038/290201a0
  29. Colditz GA, Branch LG, Lipnick RJ, Willett WC, Rosner B, Posner BM, Hennekens CH. Increased green and yellow vegetable intake and lowered cancer deaths in an elderly population. Am J Clin Nutr 1985; 41(1): 32-36 https://doi.org/10.1093/ajcn/41.1.32
  30. Stahelin HB, Gey KF, Eichholzer M, Ludin E, Brubacher G. Cancer mortality and vitamin E status. Ann N Y Acad Sci 1989; 570: 391-399 https://doi.org/10.1111/j.1749-6632.1989.tb14938.x
  31. Steinmetz KA, Potter JD. Vegetables, fruits and cancer: II. Mechanisms. Cancer Causes Control 1991; 2(6): 427-442 https://doi.org/10.1007/BF00054304
  32. Wang XD, Russell RM. Procarcinogenic and anticarcinogenic effects of beta-carotene. Nutr Rev 1999; 57(9 Pt 1): 263-272 https://doi.org/10.1111/j.1753-4887.1999.tb01809.x
  33. Knekt P, Järvinen R, Seppänen R, Rissanen A, Aromaa A, Heinonen OP, et al. Dietary antioxidants and the risk of lung cancer. Am J Epidemiol 1991; 134(5): 471-479
  34. van Poppel G, Goldbohm RA. Epidemiologic evidence for beta-carotene and cancer prevention. Am J Clin Nutr 1995; 62(6 Suppl): 1393S-1402S
  35. Hennekens CH, Buring JE, Manson JE, Stampfer M, Rosner B, Cook NR, et al. Lack of effect of long-term supplementation with beta carotene on the incidence of malignant neoplasms and cardiovascular disease. N Engl J Med 1996; 334(18): 1145-1149 https://doi.org/10.1056/NEJM199605023341801
  36. Omenn GS, Goodman GE, Thornquist MD, Balmes J, Cullen MR, Glass A, et al. Effects of a combination of beta carotene and vitamin A on lung cancer and cardiovascular disease. N Engl J Med 1996; 334(18): 1150-1155 https://doi.org/10.1056/NEJM199605023341802
  37. Lee IM, Cook NR, Manson JE, Buring JE, Hennekens CH. Beta-carotene supplementation and incidence of cancer and cardiovascular disease: The Women s Health Study. J Natl Cancer Inst 1999; 91(24): 2102-2106 https://doi.org/10.1093/jnci/91.24.2102
  38. Virtamo J, Pietinen P, Huttunen JK, Korhonen P, Malila N, Virtanen MJ, et al. Incidence of cancer and mortality following alphatocopherol and beta-carotene supplementation: A postintervention follow-up. JAMA 2003; 290(4): 476-485 https://doi.org/10.1001/jama.290.4.476
  39. Goodman GE, Thornquist MD, Balmes J, Cullen MR, Meyskens FL Jr, Omenn GS, et al. The beta-carotene and retinol efficacy trial: Incidence of lung cancer and cardiovascular disease mortality during 6-year follow-up after stopping beta-carotene and retinol supplements. J Natl Cancer Inst 2004; 96(23): 1743-1750 https://doi.org/10.1093/jnci/djh320
  40. Malila N, Taylor PR, Virtanen MJ, Korhonen P, Huttunen JK, Albanes D, et al. Effects of alpha-tocopherol and beta-carotene supplementation on gastric cancer incidence in male smokers (ATBC study, Finland). Cancer Causes Control 2002; 13(7): 617-623 https://doi.org/10.1023/A:1019556227014
  41. Bjelakovic G, Nikolova D, Simonetti RG, Gluud C. Antioxidant supplements for prevention of gastrointestinal cancers: A systematic review and meta-analysis. Lancet 2004; 364(9441): 1219-1228 https://doi.org/10.1016/S0140-6736(04)17138-9
  42. Davies AA, Davey Smith G, Harbord R, Bekkering GE, Sterne JA, Beynon R, et al. Nutritional interventions and outcome in patients with cancer or preinvasive lesions: Systematic review. J Natl Cancer Inst 2006; 98(14): 961-973 https://doi.org/10.1093/jnci/djj263
  43. Arab L, Steck-Scott S, Bowen P. Participation of lycopene and beta-carotene in carcinogenesis: Defenders, aggressors, or passive bystanders? Epidemiol Rev 2001; 23(2): 211-230 https://doi.org/10.1093/oxfordjournals.epirev.a000803
  44. Goodman GE, Schaffer S, Omenn GS, Chen C, King I. The association between lung and prostate cancer risk, and serum micronutrients: Results and lessons learned from beta-carotene and retinol efficacy trial. Cancer Epidemiol Biomarkers Prev 2003; 12(6): 518-526
  45. Mannisto S, Smith-Warner SA, Spiegelman D, Albanes D, Anderson K, van den Brandt PA, et al. Dietary carotenoids and risk of lung cancer in a pooled analysis of seven cohort studies. Cancer Epidemiol Biomarkers Prev 2004; 13(1): 40-48 https://doi.org/10.1158/1055-9965.EPI-038-3
  46. Ministry of Agriculture & Forestry, Republic of Korea. Agricultural & Forestry Statistical Yearbook 2007. [cited 2008 Dec 10]. Available from: URL: http://ebook.maf.go.kr. (Korean)
  47. Ahn YO, Yoo KY, Park BJ, Kim DH, Bae JM, Kang DH, et al. Epidemiology: The Principles and Applications. Seoul: Seoul National University Press; 2005. p.232-247. (Korean)
  48. Mulrow CD. Rationale for systematic reviews. BMJ 1994; 309(6954): 597-599 https://doi.org/10.1136/bmj.309.6954.597
  49. Flather MD, Farkouh ME, Pogue JM, Yusuf S. Strengths and limitations of meta-analysis: Larger studies may be more reliable. Control Clin Trials 1997; 18(6): 568-579 https://doi.org/10.1016/S0197-2456(97)00024-X
  50. Bae JM, Lee EJ, Guyatt G. Citrus fruit intake and stomach cancer risk: A quantitative systematic review. Gastric Cancer 2008; 11(1): 23-32 https://doi.org/10.1007/s10120-007-0447-2
  51. Heinonen OP, Albanes D, Virtamo J, Taylor PR, Huttunen JK, Hartman AM, et al. Prostate cancer and supplementation with alphatocopherol and beta-carotene: Incidence and mortality in a controlled trial. J Natl Cancer Inst 1998; 90(6): 440-446 https://doi.org/10.1093/jnci/90.6.440
  52. Cook NR, Stampfer MJ, Ma J, Manson JE, Sacks FM, Buring JE, et al. Beta-carotene supplementation for patients with low baseline levels and decreased risks of total and prostate carcinoma. Cancer 1999; 86(9): 1783-1792 https://doi.org/10.1002/(SICI)1097-0142(19991101)86:9<1783::AID-CNCR21>3.0.CO;2-N
  53. Helzlsouer KJ, Huang HY, Alberg AJ, Hoffman S, Burke A, Norkus EP, et al. Association between alpha-tocopherol, gamma-tocopherol, selenium, and subsequent prostate cancer. J Natl Cancer Inst 2000; 92(24): 2018-2023 https://doi.org/10.1093/jnci/92.24.2018
  54. Hoenjet KM, Dagnelie PC, Delaere KP, Wijckmans NE, Zambon JV, Oosterhof GO. Effect of a nutritional supplement containing vitamin E, selenium, vitamin c and coenzyme Q10 on serum PSA in patients with hormonally untreated carcinoma of the prostate: A randomised placebo-controlled study. Eur Urol 2005; 47(4): 433-439 https://doi.org/10.1016/j.eururo.2004.11.017
  55. Kirsh VA, Mayne ST, Peters U, Chatterjee N, Leitzmann MF, Dixon LB, et al. A prospective study of lycopene and tomato product intake and risk of prostate cancer. Cancer Epidemiol Biomarkers Prev 2006; 15(1): 92-98 https://doi.org/10.1158/1055-9965.EPI-05-0563
  56. Bae JM, Lee EJ, Guyatt G. Citrus fruit intake and prostate cancer risk: A quantitative systematic review. J Prev Med Public Health 2008; 41(3): 159-164 https://doi.org/10.3961/jpmph.2008.41.3.159
  57. World Cancer Research Fund in association with the American Institute of Cancer Research. Food, Nutrition, and Cancer Prevention: A Global Perspective.Washington DC: American Institute of Cancer Research; 1997
  58. Howe GR, Jain M, Miller AB. Dietary factors and risk of pancreatic cancer: Results of a Canadian population-based case-control study. Int J Cancer 1990; 45(4): 604-608 https://doi.org/10.1002/ijc.2910450405
  59. Ghadirian P, Boyle P, Simard A, Baillargeon J, Maisonneuve P, Perret C. Reported family aggregation of pancreatic cancer within a population-based case-control study in the Francophone community in Montreal, Canada. Int J Pancreatol 1991; 10(3-4): 183-196
  60. Kalapothaki V, Tzonou A, Hsieh CC, Karakatsani A, Trichopoulou A, Toupadaki N, et al. Nutrient intake and cancer of the pancreas: A case-control study in Athens, Greece. Cancer Causes Control 1993; 4(4): 383-389 https://doi.org/10.1007/BF00051342
  61. Howe GR, Burch JD. Nutrition and pancreatic cancer. Cancer Causes Control 1996; 7(1): 69-82 https://doi.org/10.1007/BF00115639
  62. Coulter ID, Hardy ML, Morton SC, Hilton LG, Tu W, Valentine D, et al. Antioxidants vitamin C and vitamin E for the prevention and treatment of cancer. J Gen Intern Med 2006; 21(7): 735-744 https://doi.org/10.1111/j.1525-1497.2006.00483.x
  63. Bae JM, Lee EJ, Guyatt G. Citrus fruit intake and pancreatic cancer risk: A quantitative systematic review. Pancreas 2008 Sep 26. [Epub ahead of print] https://doi.org/10.1097/MPA.0b013e318188c497
  64. Shapiro S. Meta-analysis/Shmeta-analysis. Am J Epidemiol 1994; 140(9): 771-778 https://doi.org/10.1093/oxfordjournals.aje.a117324
  65. Shapiro S. Is there is or is there ain t no baby? Dr. Shapiro replies to Drs. Petitti and Greenland. Am J Epidemiol 1994; 140(9): 788-791 https://doi.org/10.1093/oxfordjournals.aje.a117327
  66. Petitti DB. Of babies and bathwater. Am J Epidemiol 1994; 140(9): 779-782 https://doi.org/10.1093/oxfordjournals.aje.a117325
  67. Greenland S. Can meta-analysis be salvaged? Am J Epidemiol 1994; 140(9): 783-787 https://doi.org/10.1093/oxfordjournals.aje.a117326
  68. Egger M, Schneider M, Davey Smith G. Spurious precision? Meta-analysis of observational studies. BMJ 1998; 316(7125): 140-144 https://doi.org/10.1136/bmj.316.7125.140

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