Journal of Preventive Medicine and Public Health

  • 제42권1호
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  • Pages.29-34
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  • 2009
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  • 1975-8375(pISSN)
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  • 2233-4521(eISSN)
대한예방의학회 (The Korean Society for Preventive Medicine)
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일부 농촌 지역 성인에서 C-reactive protein농도와 경동맥 내중막 두께

C-reactive Protein and Carotid Intima-media Thickness in a Population of Middle-aged Koreans

  • 서민아 (연세대학교 의과대학 예방의학교실) ;
  • 이주영 (연세대학교 의과대학 예방의학교실) ;
  • 안성복 (연세대학교 의과대학 예방의학교실) ;
  • 김현창 (연세대학교 의과대학 예방의학교실) ;
  • 서일 (연세대학교 의과대학 예방의학교실)
  • Suh, Min-A (Department of Preventive Medicine, Yonsei University College of Medicine) ;
  • Lee, Joo-Young (Department of Preventive Medicine, Yonsei University College of Medicine) ;
  • Ahn, Song-Vogue (Department of Preventive Medicine, Yonsei University College of Medicine) ;
  • Kim, Hyeon-Chang (Department of Preventive Medicine, Yonsei University College of Medicine) ;
  • Suh, Il (Department of Preventive Medicine, Yonsei University College of Medicine)
  • 발행 : 2009.01.31
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초록

Objectives : This study was performed to evaluate the relationship between C-reactive protein(CRP) and carotid intima-media thickness(carotid IMT) in a population of middle-aged Koreans. Methods : A total of 1,054 men and 1,595 women(aged 40-70 years) from Kanghwa County, Korea, were chosen for the present study between 2006 and 2007. We measured high-sensitivity CRP and other major cardiovascular risk factors including anthropometrics, blood pressure, blood chemistry, and carotid ultrasonography. Health related questionnaires were also completed by each study participant. Carotid IMT value was determined by the maximal IMT at each common carotid artery. The relationship between CRP level and carotid IMT was assessed using multiple linear and logistic regression models after adjustment for age, body mass index, menopause(women), systolic blood pressure, total/HDL cholesterol ratio, triglyceride level, fasting glucose, smoking, and alcohol consumption. Results : Mean carotid IMT values from the lowest to highest quartile of CRP were 0.828, 0.873, 0.898, and 0.926 mm for women(p for trend<0.001), and 0.929, 0.938, 0.949, and 0.979 mm for men(p for trend=0.032), respectively. After adjustment for major cardiovascular risk factors, the relationship between CRP and carotid IMT was significant in women(p for trend=0.017), but not in men(p for trend=0.798). Similarly, adjusted odds ratio of increased IMT, defined as the sex-specific top quartile, for the highest versus lowest CRP quartiles was 1.55(95% CI=1.06-2.26) in women, but only 1.05(95% CI=0.69-1.62) in men. Conclusions : CRP and carotid IMT levels appear to be directly related in women, but not in men.

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참고문헌

  1. Berliner JA, Navab M, Fogelman AM, Frank JS, Demer LL, Edwards PA, et al. Athero sclerosis: Basic mechanisms. Oxidation, inflammation, and genetics. Circulation 1995; 91(9): 2488-2496 https://doi.org/10.1161/01.CIR.91.9.2488
  2. Hansson GK. Inflammation, atherosclerosis, and coronary artery disease. N Engl J Med 2005; 352(16): 1685-1695 https://doi.org/10.1056/NEJMra043430
  3. Rifai N, Ridker PM. High-sensitivity C-reactive protein: A novel and promising marker of coronary heart disease. Clin Chem 2001; 47(3): 403-411
  4. Ferranti SD, Rifai N. C-reactive protein: A nontraditional serum marker of cardiovascular risk. Cardiovasc Pathol 2007; 16(1): 14-21 https://doi.org/10.1016/j.carpath.2006.04.006
  5. Ridker PM, Cushman M, Stampfer MJ, Tracy RP, Hennekens CH. Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men. N Engl J Med 1997; 336(14): 973-979 https://doi.org/10.1056/NEJM199704033361401
  6. Ridker PM, Hennekens CH, Buring JE, Rifai N. C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. N Engl J Med 2000; 342(12): 836-843 https://doi.org/10.1056/NEJM200003233421202
  7. Chambless LE, Heiss G, Folsom AR, Rosamond W, Szklo M, Sharrett AR, et al. Association of coronary heart disease incidence with carotid arterial wall thickness and major risk factors: The Atherosclerosis Risk in Communities (ARIC) Study, 1987-1993. Am J Epidemiol 1997; 146(6): 483-494
  8. Pearson TA , Mensah GA, Alexander RW, Anderson JL, Cannon RO, Criqui M, et al. Markers of inflammation and cardiovascular disease: Application to clinical and public health practice: A statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association. Circulation 2003; 107(3): 499-511 https://doi.org/10.1161/01.CIR.0000052939.59093.45
  9. Lorenz MW, Karbstein P, Markus HS, Sitzer M. High-sensitivity C-reactive protein is not associated with carotid intima-media pro gression: The Carotid Atherosclerosis Progression Study. Stroke 2007; 38(6): 1774-1779 https://doi.org/10.1161/STROKEAHA.106.476135
  10. Hayaishi-Okano R, Yamasaki Y, Katakami N, Ohtoshi K, Gorogawa S, Kuroda A, et al. Elevated C-reactive protein associated with early-stage carotid atherosclerosis in young subjects with type 1 diabetes. Diabetes care 2002; 25(8): 1432-1438 https://doi.org/10.2337/diacare.25.8.1432
  11. Sitzer M, Markus HS, Mendall MA, Liehr R, Knorr U, Steinmertz H. C-reactive protein and carotid intima media thickness in a community population. J Cardiovasc Risk 2002; 9(2): 97-103 https://doi.org/10.1097/00043798-200204000-00005
  12. Thakore AH, Guo CY, Larson MG, Corey D, Wang TJ, Vasan RS, et al. Association of multiple inflammatory markers with carotid intimal medial thickness and stenosis (from the Framingham Heart Study). Am J Cardiol 2007; 99(11): 1598-1602 https://doi.org/10.1016/j.amjcard.2007.01.036
  13. Elias-Smale SE, Kardys I, Oudkerk M, Hofman A, Witteman JC. C-reactive protein is related to extent and progression of coronary and extra-coronary atherosclerosis; Results from the Rotterdam study. Atherosclerosis 2007; 195(2): e195-202 https://doi.org/10.1016/j.atherosclerosis.2007.07.006
  14. Choi SH, Kim HC, Ahn CW, Cho HK, Cha BS, Chung YS, et al. Is high-sensitivity Creactive protein associated with carotic atherosclerosis in healthy Koreans? Eur J Cardiovasc Prev Rehabil 2005; 12(6): 548-554 https://doi.org/10.1097/00149831-200512000-00006
  15. Ryu SY, Lee YS, Park J, Kang MG, Kim KS. Relations of plasma high-sensitivity C-reactive protein to various cardiovascular risk factors. J Korean Med Sci 2005; 20(3): 379-383 https://doi.org/10.3346/jkms.2005.20.3.379
  16. Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL Jr, et al. The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: The JNC 7 Report. JAMA 2003; 289(19): 2560-2572 https://doi.org/10.1001/jama.289.19.2560
  17. Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III). JAMA 2001; 285(19): 2486-2497 https://doi.org/10.1001/jama.285.19.2486
  18. World Health Organization Western Pacific Region, International Association for the Study of Obesity, International Obesity Task Force. The Asia-Pacific Perspective: Redefining Obesity and its Treatment. Sydney: Health Communications Australia; 2000
  19. Saito I, Sato S, Nakamura M, Kokubo Y, Mannami T, Adachi H, et al. A low level of Creactive protein in Japanese adults and its association with cardiovascular risk factors: The Japan NCVC-Collaborative Inflammation Cohort (JNIC) Study. Atherosclerosis 2007; 194(1): 238-244 https://doi.org/10.1016/j.atherosclerosis.2006.07.032
  20. Ridker PM, Buring JE, Cook NR, Rifai N. Creactive protein, the metabolic syndrome, and risk of incident cardiovascular events: An 8- year follow-up of 14179 initially healthy American women. Circulation 2003; 107(3): 391-397 https://doi.org/10.1161/01.CIR.0000055014.62083.05
  21. Wang TJ, Nam BH, Wilson PW, Wolf PA, Levy D, Polak JF, et al. Association of Creactive protein with carotid atherosclerosis in men and women: The Framingham Heart Study. Atheroscler Thromb Vasc Biol 2002; 22(10): 1662-1667 https://doi.org/10.1161/01.ATV.0000034543.78801.69
  22. Kang ES, Kim HJ, Lee S, Kim HJ, Kim YM, Hur KY, et al. Serum high sensitivity Creactive protein is associated with carotid intima-media thickness, but not with microvascular complications in type 2 diabetes. Korean J Med 2003; 65(4): 443-450. (Korean)
  23. Song HY, Song YS, Ahn CW, Kang SW, Choi KH, Ha SY, et al. Realationship between inflammatory markers and high resolution Bmode carotid artery ultrasono-graphy in continuous ambulatory peritoneal dialysis (CAPD) patients. Korean J Nephrol 2002; 21(2): 285-294. (Korean)
  24. Son JC, Kim BT, Lee DJ, Choi HK, Chung HJ, Kim GM. The most associated risk factor of the metabolic syndrome with C-reactive protein. J Korean Soc Study Obes 2003; 12(1): 15-23. (Korean)
  25. Eckel RH, Grundy SM, Zimmet PZ. The metabolic syndrome. Lancet 2005; 365(9468): 1415-1428 https://doi.org/10.1016/S0140-6736(05)66378-7
  26. Timpson NJ, Lawlor DA, Harbord RM, Gaunt TR, Day IN, Palmer LJ, et al. C-reactive protein and its role in metabolic syndrome: Mendelian randomization study. Lancet 2005; 366(9468): 1954-1959 https://doi.org/10.1016/S0140-6736(05)67786-0
  27. Hotamisiligil GS, Arner P, Caro JF, Atkinson RL, Spiegelman BM. Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance. J Clin Invest 1995; 95(5): 2409-2415 https://doi.org/10.1172/JCI117936
  28. Warren RS, Starnes HF, Gabrilove JL, Oettgen HF, Brennan MF. The acute metabolic effects of tumor necrosis factor administration in human. Arch Surg 1987; 122(12): 1396-1400 https://doi.org/10.1001/archsurg.1987.01400240042007

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