Journal of Acupuncture Research

  • 제26권1호
  • /
  • Pages.121-133
  • /
  • 2009
  • /
  • 2586-288X(pISSN)
  • /
  • 2586-2898(eISSN)
대한침구의학회 (Korean Acupuncture & Moxibustion Medicine Society)
권호 표지

섬수의 임상적 활용을 위한 문헌적 고찰 －독성 및 수치를 중심으로－

A Bibliographic Studies on the Bufonis Venenum for Clinical Treatment: Important to Toxicity and Processing

  • 이승훈 (경희대학교 한의과대학 침구학교실) ;
  • 최도영 (경희대학교 한의과대학 침구학교실) ;
  • 백용현 (경희대학교 한의과대학 침구학교실) ;
  • 이재동 (경희대학교 한의과대학 침구학교실)
  • Lee, Seung-Hoon (Dept. of Acupuncture & Moxibustion, College of Oriental Medicine, Kyung Hee University) ;
  • Choi, Do-Young (Dept. of Acupuncture & Moxibustion, College of Oriental Medicine, Kyung Hee University) ;
  • Baek, Yong-Hyeon (Dept. of Acupuncture & Moxibustion, College of Oriental Medicine, Kyung Hee University) ;
  • Lee, Jae-Dong (Dept. of Acupuncture & Moxibustion, College of Oriental Medicine, Kyung Hee University)
  • 발행 : 2009.02.20
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Objectives : The purpose of this study is to find out the clinical possibility of Bufonis Venenum used without toxicity and side effect. Methods : We investigated the pharmacological effects, toxicity and processing of Bufonis Venenum through the literatures and studies. Results : Bufonis Venenum is made by parotid gland of dermato gland of Bufo bufo gargarizns or B. melanostictus Schneider, and it is dried for using. The medical ation of Bufonis Venenum are cardiotonic, respiration stimulation, anticancer, topical anesthesia. The toxic symptoms of Bufonis Venenum are relative with digestive, circulatory, nervous system similared with digitalis toxicity. It is important to take 0.015-0.03g by mouth, external use about 1-4% 0.5-3ml and 2-8ml injections by 20ml mix to 5% dextrose fluid. Bufonis Venenum is processed to prevent toxicity and evaluate efficacy by alcohol and milk. There are 68 prescription consisted by Bufonis Venenum in KTKP(Korean Traditional Knowledge Portal). They usually use for antiabcess, anticancer with Moschus moschiferus(麝香), Cinnabar(朱砂). Conclusions : The results from above literary studies show that internal, external medicine and Aqua-acupuncture of Bufonis Venenum could be clinically used to sedative, antiinflammatory, anticancer and topical ataralgesia without toxity through optimum dose and processing.

키워드

참고문헌

  1. 上海中醫學院. 中草藥學. 香港 : 中華商務印書館. 1975 : 627-9.
  2. 전국한의과대학 본초학교수. 본초학. 영림사. 2000 : 527-8.
  3. 김영춘, 정성학, 김종호 외. 섬수(Bufonis Venenum) 추출물의 약리작용. 응용약물학회지. 2001 ; 9(1) : 51-4.
  4. 김민희. The study of the bufonis venenum on the anti-inflammatory effects. 동의대학교 대학원. 2006.
  5. 조종관, 김동식. 항암제로 활용되는 섬서 및 섬수에 관한 문헌적 고찰. 1996 ; 4(2) : 117-28.
  6. 박태열. 섬수 추출물의 T24 인체방광암세포의 증식억제 및 apoptosis 유발에 관한 연구. 동의대학교 교육대학원. 2005.
  7. 장성은. 산자고, 섬수, 반묘가 TXM 18 흑색종에 미치는 항암효과에 대한 연구. 경희대학교 대학원. 2001.
  8. 宋奉桔. 消風散加蟾酥가 人體皮膚癌細胞(A431)에 미치는 實驗的 硏究. 대전대학교 대학원. 1998.
  9. 金喜澤. 청열소독산가섬수가 피부암세포(A431)에 미치는 영향. 대전대학교 대학원. 1995.
  10. 宋恪鎬. 선방활명음가섬소가 피부암세포(A431)에 미치는 영향. 대전대학교 대학원. 1995.
  11. 김재욱. 蟾酥의 毒性作用 및 抗血栓에 關한 實驗的 硏究. 경희대학교 대학원. 1994.
  12. 沈嘉茵, 袁旭江. 蟾酥的采集加工及炮制研究 概况. 时珍国医国药. 2008 ; 19(2) : 275-7.
  13. 王玲华, 宋克中. 蟾酥临床应用近况. Chin JMAP. 2006 July ; 23(7) : 618-20.
  14. 上海中醫學院. 中草藥學. 中華商務印書館香港分館. 1975 : 627-9.
  15. 金昌玟 외 釋. 中藥大辭典. 鼎談. 1998 : 2376-82.
  16. 黃致元. 蟾酥가 中樞神經系 및 循環器系에 미치는 影響. 동국대학교 대학원. 1996.
  17. Xie JT, Dey L, Wu JA, Lowell TK, Yuan CS. Cardiac toxicity of resibufogenin: electrophysiological evidence. Acta Pharmacol Sin. 2001 ; 22 : 289- 97.
  18. 강계성, 권기록. 蟾酥에 關한 文獻的 考察. 大韓藥鍼學會誌. 2001 ; 4(2) : 35-47.
  19. 徐國鈞 외. 中國藥材學. 北京 : 中國醫藥科技出版社. 1996 : 1810-6.
  20. 한방약리학 교재편찬위원회. 한방약리학. 신일상사. 2006 : 446-50.
  21. Brubacher JR, Ravikumar PR, Bania T, Heller MB, Hoffman RS. Treatment of toad venom poisoning with digoxin-specific Fab fragments. Chest. 1996 Nov ; 110(5) : 1282-8. https://doi.org/10.1378/chest.110.5.1282
  22. Gowda RM, Cohen RA, Khan IA. Toad venom poisoning: resemblance to digoxin toxicity and therapeutic implications. Heart. 2003 Apr ; 89(4) : e14. https://doi.org/10.1136/heart.89.4.e14
  23. Links Chen KK, Kovaríková A. Pharmacology and toxicology of toad venom. J Pharm Sci. 1967 Dec ; 56(12) : 1535-41. https://doi.org/10.1002/jps.2600561202
  24. Bhuiyan MB, Fant ME, Dasgupta A. Study on mechanism of action of Chinese medicine Chan Su: dose-dependent biphasic production of nitric oxide in trophoblastic BeWo cells. Clin Chim Acta. 2003 Apr ; 330(1-2) : 179-84. https://doi.org/10.1016/S0009-8981(03)00047-0
  25. Chan WY, Ng TB, Yeung HW. Examination for toxicity of a Chinese drug, the toad glandular secretory product Chan Su, in pregnant mice and embryos. Biology of the Neonate. 1995 ; 67(5) : 376-80. https://doi.org/10.1159/000244188
  26. Kawahara K, Mikage M. Studies on toad venom (2) : Examination of the drying processing method. Yakugaku Zasshi. 2000 Nov ; 120(11) : 1217-9.
  27. Kawahara K, Mikage M.Studies on toad venom (3) : effect of metals on the quality of toad venom torrefied on a metal plate. Yakugaku Zasshi. 2002 Jan ; 122(1) : 117-9. https://doi.org/10.1248/yakushi.122.117
  28. 김재익. 임상본초학강좌. 대성의학사. 2001. 489-90.
  29. Fishchenko L Ya, Neiko EM. The action of toad venom on wound healing. Bulletin of Experimental Biology and Medicine. 1962 July ; 52(6) : 1430-3. https://doi.org/10.1007/BF00785313