Journal of the Korean Academy of Child and Adolescent Psychiatry

Korean Academy of Child and Adolescent Psychiatry (대한소아청소년정신의학회)
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The Association of COMT Gene Polymorphism and Tourette Syndrome : A Family Based and Case Control Study

한국인 뚜렛장애에서 환자군과 가족군간의 COMT 유전자 다형성의 연관성

  • Lim, Won-Weok (Department of Psychiatry, College of Medicine, Dankook University) ;
  • Lim, Myung-Ho (Department of Psychiatry, College of Medicine, Dankook University) ;
  • Song, Eun-Young (Cell Biology Laboratory, Korean Research Institute of Bioscience and Biotechnology) ;
  • Park, Mi-Young (Cell Biology Laboratory, Korean Research Institute of Bioscience and Biotechnology) ;
  • Kim, Jong-Wan (Department of Diagnostic & Evaluation, College of Medicine, Dankook University) ;
  • Kim, Tae-Hyun (Department of Anatomy & Cell Biology, College of Medicine, Dong-A University) ;
  • Shim, Se-Hoon (Department of Psychiatry, College of Medicine, Soonchonhyang University) ;
  • Park, Tae-Won (Department of Psychiatry, College of Medicine, Chonbuk National University) ;
  • Kim, Hyun-Woo (Department of Psychiatry, College of Medicine, Dankook University)
  • 임원석 (단국대학교 의과대학 정신과학교실) ;
  • 임명호 (단국대학교 의과대학 정신과학교실) ;
  • 송은영 (한국생명공학연구원 세포생물학연구실) ;
  • 박미영 (한국생명공학연구원 세포생물학연구실) ;
  • 김종완 (단국대학교 의과대학 진단검사학교실) ;
  • 김태현 (동아대학교 의과대학 해부학교실) ;
  • 심세훈 (순천향대학교 의과대학 신경정신과학교실) ;
  • 박태원 (전북대학교 의과대학 정신과학교실) ;
  • 김현우 (단국대학교 의과대학 정신과학교실)
  • Published : 2009.02.28
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Abstract

Objectives : Tourette disorder is known to be a disease with a strong genetic trait. There has been some recent research on the relationship between the allelic frequency distribution and Tourette disorder. In Korea, the relationship between the genetic type and the alleles for the COMT gene has been studied in Tourette patients. Methods : Seventy two patients who were diagnosed with Tourette disorder according to the DSM-IV diagnostic criteria were selected for this study. The diagnosis and clinical features were confirmed by the Yale Global Tic Severity Scale. For the control group, the parents of the patients were chosen. Blood samples were taken from the 289 subjects. DNA was extracted from the blood lymphocytes and PCR was performed for assessing COMT gene. Results : On comparing the Tourette disorder transmitted group and the not-transmitted group, no significant difference was seen between the COMT genetic type and the allelic distribution. Conclusion : Even though this result is viewed that there is no relationship between Tourette disorder and the COMT gene, it is difficult to firmly accept this negative result. Follow up studies with a larger patient population or pure subgroups are expected in the future.

Keywords

References

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