Advances in Traditional Medicine

  • 제9권1호
  • /
  • Pages.74-82
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  • 2009
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  • 2662-4052(pISSN)
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  • 2662-4060(eISSN)
경희대학교 융합한의과학연구소 (Kyung Hee Oriental Medicine Research Center)
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Anti-inflammatory activity of aqueous methanolic extract of Swietenia mahagoni (L.) Jacq. (Meliaceae) leaves

  • Roy, S (Drug Development Division, Indian Institute of Chemical Biology) ;
  • Besra, SE (Drug Development Division, Indian Institute of Chemical Biology) ;
  • Banerjee, B (Department of Chemistry, K.N.College) ;
  • Mukherjee, J (Department of Life Science & Biotechnology, Jadavpur University) ;
  • Vedasiromoni, JR (Drug Development Division, Indian Institute of Chemical Biology)
  • 발행 : 2009.03.31
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초록

Pharmacological investigations were carried out with aqueous methanolic extract (AME) of Swietenia mahagoni (L.) Jacq. (Meliaceae) leaves. Acute toxicity studies revealed that the $LD_{50}$ dose of AME was 600 mg/kg, i.p. AME was found to possess significant anti-inflammatory activity in acute, sub-chronic and chronic models of inflammation. AME selectively inhibited cyclooxygenase (COX)-2 activity, which is involved in arachidonic acid metabolism and biosynthesis of prostaglandins under inflammatory conditions. Treatment with AME significantly enhanced total peritoneal cell count and the number of macrophages in normal mice, which revealed that AME may also alter the immune response along with its anti-inflammatory effect. The saponins or the alkaloids present in AME may be responsible for the anti-inflammatory activity.

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