Advances in Traditional Medicine

  • 제9권1호
  • /
  • Pages.58-66
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  • 2009
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  • 2662-4052(pISSN)
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  • 2662-4060(eISSN)
경희대학교 융합한의과학연구소 (Kyung Hee Oriental Medicine Research Center)
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Inhibitory effects of Tinospora cordifolia and Rubia cordifolia Linn. on egg albumin-induced experimental allergic conjunctivitis in rats

  • Rishit, Zalawadia (Pharmacy Department, Faculty of Tech. & Engg., Kalabhavan, M. S. University of Baroda) ;
  • Chintan, Gandhi (Pharmacy Department, Faculty of Tech. & Engg., Kalabhavan, M. S. University of Baroda) ;
  • Vaibhav, Patel (Pharmacy Department, Faculty of Tech. & Engg., Kalabhavan, M. S. University of Baroda) ;
  • Balaraman, R (Pharmacy Department, Faculty of Tech. & Engg., Kalabhavan, M. S. University of Baroda)
  • 발행 : 2009.03.31
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초록

Allergic conjunctivitis is the most common allergic disease. These diseases are severe & frequent which requires search of new treatments. The aim of the study was to investigate the effects of Tinospora cordifolia (TC), Rubia cordifolia Linn. (RC) on experimentally induced allergic conjunctivitis in rats. In this study, dried water soluble extracts of TC and RC. (250 and 500 mg/kg, p.o. for 7 days) were evaluated for their antiallergic activity in Wistar rats. They were tested for inhibition of egg albumin-induced vascular permeability, inhibition of histamine release from the rat conjunctiva as well as in histamine content in tears. TC and RC showed significant (P < 0.05) inhibition in vascular permeability, inhibition in histamine release from the rat conjunctiva which is reflected by reduced level of histamine content in tears. The activities were found to be comparable to azelastine hydrochloride. These results suggest that the inhibitory effect on egg albumin-induced experimental allergic conjunctivitis in rat may be due to the antihistaminic activity of TC and RC. Our studies provide evidence that TC and RC may be beneficial in the treatment of allergic conjunctivitis.

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