DOI QR코드

DOI QR Code

The Association of Central Obesity with Type 2 Diabetes among Koreans according to the Serum Gamma-Glutamyltransferase Level: Korean Genome and Epidemiology Study

혈청 Gamma-Glutamyltransferase에 따른 복부비만과 제2형 당뇨병간의 관련성: Korean Genome and Epidemiology Study

  • Shin, Ji-Yeon (Department of Preventive Medicine, Kyungpook National University School of Medicine) ;
  • Hwang, Jun-Hyun (Department of Preventive Medicine, Kyungpook National University School of Medicine) ;
  • Jeong, Jin-Young (Hallym Research Institute of Clinical Epidermiology, Hallym University College of Medicine) ;
  • Kim, Sung-Hi (Department of Family Medicine, Daegu Catholic University Hospital) ;
  • Moon, Jai-Dong (Department of Occupational and Environmental Medicine, Chonnam National University College of Medicine) ;
  • Roh, Sang-Chul (Department of Occupational and Environmental Medicine College of Medicine, Dankook University) ;
  • Kim, Young-Wook (Department of Occupational and Environmental Medicine, Masan Samsung Hospital) ;
  • Kim, Yang-Ho (Department of Occupational and Environmental Medicine, Ulsan University Hospital, University of Ulsan College of Medicine) ;
  • Leem, Jong-Han (Department of Social.Medicine, Inha University School of Medicine) ;
  • Ju, Young-Su (Department of Occupational and Environmental Medicine, Hallym University Sacred Heart Hospital) ;
  • Hong, Young-Seoub (Department of Preventive Medicine, Dong-A University College of Medicine) ;
  • Ha, Eun-Hee (Department of Preventive Medicine, Ewha Womans University Medical School, Department of Social and Preventive Medicine) ;
  • Lee, Yong-Hwan (Department of Preventive Medicine, Kosin University College of Medicine) ;
  • Lee, Duk-Hee (Department of Preventive Medicine, Kyungpook National University School of Medicine) ;
  • Kim, Dong-Hyun (Hallym Research Institute of Clinical Epidermiology, Hallym University College of Medicine)
  • 신지연 (경북대학교 의학전문대학원 예방의학교실) ;
  • 황준현 (경북대학교 의학전문대학원 예방의학교실) ;
  • 정진영 (한림대학교 임상역학연구소) ;
  • 김성희 (대구카톨릭대학교병원 가정의학과) ;
  • 문재동 (전남대학교 의학전문대학원 산업의학과) ;
  • 노상철 (단국대학교 의과대학 산업의학교실) ;
  • 김영욱 (마산 삼성병원 산업의학과) ;
  • 김양호 (울산대학교 의과대학 산업.환경의학교실) ;
  • 임종한 (인하대학교 의학전문대학원 사회의학교실) ;
  • 주영수 (한림대학교성심병원 산업의학과) ;
  • 홍영습 (동아대학교 의과대학 예방의학교실) ;
  • 하은희 (이화여자대학교 의학전문대학원 예방의학교실) ;
  • 이용환 (고신대학교 의과대학 예방의학교실) ;
  • 이덕희 (경북대학교 의학전문대학원 예방의학교실) ;
  • 김동현 (한림대학교 임상역학연구소)
  • Published : 2009.11.30

Abstract

Objectives : This cross-sectional study was performed to examine if the serum gamma-glutamyltransferase (GGT) level that is within its normal range is associated with the risk of type 2 diabetes and if the association between the waist hip ratio (WHR) and type 2 diabetes is different depending on the serum GGT levels. Methods : The study subjects were 23,436 persons aged 40 years or older and who participated in regular health check-ups at 11 hospitals (males: 5,821, females: 17,615). The gender-specific quintiles of the serum GGT and WHR were used to examine the associations with type 2 diabetes. Results : The serum GGT levels within their normal range were positively associated with type 2 diabetes only in women. The adjusted odds ratios (ORs) were 1.0, 1.0, 1.4, 2.1, and 2.5 according to the quintiles of the serum GGT ($p_{trend}$<0.01). The WHR was more strongly associated with the prevalence of diabetes among the women with a high-normal serum GGT level as compared with those with a low-normal serum GGT level (p for interaction=0.02). For example, the adjusted ORs for women with a low normal serum GGT level were 1.0, 1.2, 1.5, 2.2, and 2.4 according to the quintiles of the WHR, while those figures were 1.0, 2.4, 3.6, 5.0, and 8.3 among the women with a high normal serum GGT level. However, in men, the serum GGT was very weakly associated with type 2 diabetes and the association between the WHR and type 2 diabetes was not different depending on the serum GGT level. Conclusions : Serum GGT within its normal range was positively associated with type 2 diabetes, and central obesity was more strongly associated with the prevalence of type 2 diabetes when the serum GGT level was highnormal. However, these associations were observed only in women, which is different from the previous findings. The stronger relation between central obesity and type 2 diabetes among women with a high-normal serum GGT level can be useful for selecting a group that is at high risk for type 2 diabetes irregardless of whatever the underlying mechanism is.

Keywords

References

  1. Brenner H, Rothenbacher D, Arndt V, Schuberth S, Fraisse E, Fliedner TM. Distribution, determinants, and prognostic value of gamma-glutamyltransferase for all-cause mortality in a cohort of construction workers from southern Germany. Prev Med 1997; 26(3): 305-310 https://doi.org/10.1006/pmed.1997.0144
  2. Nilssen O, Forde OH, Brenn T. The Tromso Study: Distribution and population determinants of gamma-glutamyltransferase. Am J Epidemiol 1990; 132(2): 318-326 https://doi.org/10.1093/oxfordjournals.aje.a115661
  3. Lim JS, Kim YJ, Chun BY, Yang JH, Lee DH, Kam S. The association between serum GGT level within normal range and risk factors of cardiovascular diseases. J Prev Med Public Health 2005; 38(1): 101-106. (Korean)
  4. Lee DH, Jacobs DR Jr, Gross M, Kiefe CI, Roseman J, Lewis CE, et al. Gammaglutamyltransferase is a predictor of incident diabetes and hypertension: The Coronary Artery Risk Development in Young Adults (CARDIA) Study. Clin Chem 2003; 49(8): 1358-1366 https://doi.org/10.1373/49.8.1358
  5. Lee DH, Ha MH, Kim JH, Christiani DC, Gross MD, Steffes M, et al. Gamma-glutamyltransferase and diabetes: A 4 year follow-up study. Diabetologia 2003; 46(3): 359-364 https://doi.org/10.1007/s00125-003-1036-5
  6. Wannamethee G, Ebrahim S, Shaper AG. Gamma-glutamyltransferase: Determinants and association with mortality from ischemic heart disease and all causes. Am J Epidemiol 1995; 142(7): 699-708 https://doi.org/10.1093/oxfordjournals.aje.a117699
  7. Perry IJ, Wannamethee SG, Shaper AG. Prospective study of serum gamma-glutamyltransferase and risk of NIDDM. Diabetes Care 1998; 21(5): 732-737 https://doi.org/10.2337/diacare.21.5.732
  8. Nannipieri M, Gonzales C, Baldi S, Posadas R, Williams K, Haffner SM, et al. Liver enzymes, the metabolic syndrome, and incident diabetes: The Mexico city diabetes study. Diabetes Care 2005; 28(7): 1757-1762 https://doi.org/10.2337/diacare.28.7.1757
  9. Miura K, Nakagawa H, Nakamura H, Tabata M, Nagase H, Yoshida M, et al. Serum gamma-glutamyl transferase level in predicting hypertension among male drinkers. J Hum Hypertens 1994; 8(6): 445-449
  10. Meisinger C, Lowel H, Heier M, Schneider A, Thorand B, KORA Study Group. Serum gamma-glutamyltransferase and risk of type 2 diabetes mellitus in men and women from the general population. J Intern Med 2005; 258(6): 527-535 https://doi.org/10.1111/j.1365-2796.2005.01572.x
  11. Ruttmann E, Brant LJ, Concin H, Diem G, Rapp K, Ulmer H, et al. Gammaglutamyltransferase as a risk factor for cardiovascular disease mortality: An epidemiological investigation in a cohort of 163,944 Austrian adults. Circulation 2005; 112(14): 2130-2137 https://doi.org/10.1161/CIRCULATIONAHA.105.552547
  12. Lee DH, Silventoinen K, Jacobs DR Jr, Jousilahti P, Tuomileto J. Gammaglutamyltransferase, obesity, and the risk of type 2 diabetes: Observational cohort study among 20,158 middle-aged men and women. J Clin Endocrinol Metab 2004; 89(11): 5410-5414 https://doi.org/10.1210/jc.2004-0505
  13. Andre P, Balkau B, Born C, Charles MA, Eschwege E, D.E.S.I.R. Study Group. Threeyear increase of gamma-glutamyltransferase level and development of type 2 diabetes in middle-aged men and women: The D.E.S.I.R. cohort. Diabetologia 2006; 49(11): 2599-2603 https://doi.org/10.1007/s00125-006-0418-x
  14. Jousilahti P, Rastenyte D, Tuomilehto J. Serum gamma-glutamyl transferase, self-reported alcohol drinking, and the risk of stroke. Stroke 2000; 31(8): 1851-1855 https://doi.org/10.1161/01.STR.31.8.1851
  15. Mensah GA, Mokdad AH, Ford E, Narayan KM, Giles WH, Vinicor F, et al. Obesity, metabolic syndrome, and type 2 diabetes: Emerging epidemics and their cardiovascular implications. Cardiol Clin 2004; 22(4): 485-504 https://doi.org/10.1016/j.ccl.2004.06.005
  16. Ryu SH, Beck SH, Chang YS, Kim DI, Suh BS, Kim WS, et al. Abdominal obesity in relation to the incidence of type 2 diabetes mellitus and impaired fasting glucose among some Korean adults: A retrospective cohort study. J Prev Med Public Health 2004; 37(4):359-365. (Korean)
  17. Lim JS, Lee DH, Park JY, Jin SH, Jacobs DR Jr. A strong interaction between serum gamma-glutamyltransferase and obesity on the risk of prevalent type 2 diabetes: Results from the Third National Health and Nutrition Examination Survey. Clin Chem 2007; 53(6): 1092-1098 https://doi.org/10.1373/clinchem.2006.079814
  18. Huxley R, Barzi F, Stolk R, Caterson I, Gill T, Lam TH, et al. Ethnic comparisons of obesity in the Asia-Pacific region: Protocol for a collaborative overview of cross-sectional studies. Obes Rev 2005; 6(3): 193-198 https://doi.org/10.1111/j.1467-789X.2005.00189.x
  19. Deurenberg P, Deurenberg-Yap M, Guricci S. Asians are different from Caucasians and from each other in their body mass index/body fat per cent relationship. Obes Rev 2002; 3(3): 141-146 https://doi.org/10.1046/j.1467-789X.2002.00065.x
  20. Kim DJ, Noh JH, Cho NH, Lee BW, Choi YH, Jung JH, et al. Serum gammaglutamyltransferase within its normal concentration range is related to the presence of diabetes and cardiovascular risk factors. Diabet Med 2005; 22(9): 1134-1140 https://doi.org/10.1111/j.1464-5491.2005.01581.x
  21. Sabanayagam C, Shankar A, Li J, Pollard C, Ducatman A. Serum gamma-glutamyl transferase level and diabetes mellitus among US adults. Eur J Epidemiol 2009; 24(7): 369-373 https://doi.org/10.1007/s10654-009-9346-7
  22. Zoppini G, Targher G, Trombetta M, Lippi G, Muggeo M. Relationship of serum gammaglutamyltransferase to atherogenic dyslipidemia and glycemic control in type 2 diabetes. Obesity (Silver Spring) 2009; 17(2): 370-374 https://doi.org/10.1038/oby.2008.544
  23. Grundy SM. Gamma-glutamyl transferase: Another biomarker for metabolic syndrome and cardiovascular risk. Arterioscler Thromb Vasc Biol 2007; 27(1): 4-7 https://doi.org/10.1161/01.ATV.0000253905.13219.4b
  24. Marchesini G, Brizi M, Bianchi G, Tomassetti S, Bugianesi E, Lenzi M, et al. Nonalcoholic fatty liver disease: A feature of the metabolic syndrome. Diabetes 2001; 50(8): 1844-1850 https://doi.org/10.2337/diabetes.50.8.1844
  25. Lee DH, Blomhoff R, Jacobs DR Jr. Is serum gamma glutamyltransferase a marker of oxidative stress? Free Radic Res 2004; 38(6): 535-539 https://doi.org/10.1080/10715760410001694026
  26. Shin JY, Kim YK, Park SG, Lee JN, Kim HC, Leem JH, et al. The clinical importance of an increase in serum-glutamyltransferase concentration. Korean J Occup Environ Med 2005; 17(1): 1-9. (Korean)
  27. Lee DH, Jacobs DR Jr. Association between serum concentrations of persistent organic pollutants and gamma glutamyltransferase: Results from the National Health and Examination Survey 1999-2002. Clin Chem 2006; 52(9): 1825-1827 https://doi.org/10.1373/clinchem.2006.071563
  28. Lee DH, Lee IK, Song K, Steffes M, Toscano W, Baker BA, et al. A strong dose-response relation between serum concentrations of persistent organic pollutants and diabetes: Results from the National Health and Examination Survey 1999-2002. Diabetes Care 2006; 29(7): 1638-1644 https://doi.org/10.2337/dc06-0543

Cited by

  1. Serum gamma-glutamyl transferase and risk of type 2 diabetes in the general Korean population: a Mendelian randomization study vol.25, pp.17, 2009, https://doi.org/10.1093/hmg/ddw226
  2. Uric Acid and GGT Have Causal Relations with Abdominal Obesity: A Real-Life Research in Turkish Population with 1214 Diabetics vol.7, pp.2, 2009, https://doi.org/10.4236/jbm.2019.72001
  3. 제2형 당뇨병 환자에서 피부두겹두께의 측정부위 예측 및 비만지표들 간의 관련성 vol.22, pp.1, 2020, https://doi.org/10.7586/jkbns.2020.22.1.36