Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
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Oral Amelanotic Malignant Melanoma in a Dog: Melan A Immunohistochemical Findings

개에서 발생한 구강 멜라닌결핍 악성흑색종 예 : Melan A 면역화학조직 염색 고찰

  • Kang, Min-Hee (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University) ;
  • Park, Chul (Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California Davis) ;
  • Park, Hee-Myung (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University)
  • 강민희 (건국대학교 수의과대학 내과학교실) ;
  • 박철 (미국 캘리포니아 데이비스 수의과대학) ;
  • 박희명 (건국대학교 수의과대학 내과학교실)
  • Published : 2009.12.31
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Abstract

A 10-year-old intact male mixed breed dog was presented with a three-month history of massive oral mass. Physical examination revealed extending mass from the right upper gingiva. No metastasis was found at the time of presentation. Histopathologic examination of biopsied tissue from the oral mass was consistent with a neuroendocrine tumor with generalized epithelioid cells and few spindle cells. There were highly mitoses and no visible melanin granules with H&E staining. Immunohistochemical staining for Melan A was performed on section of tumor and was strongly positive. Diagnosis was made as amelanotic malignant melanoma based on histopathology with Melan A immunohistochemistry. This case study indicates that the Melan A immunohistochemical staining may be valuable to diagnose amelanotic malignant melanoma in dogs.

10년령의 수컷 잡종견이 3개월 간의 구강내 궤양성 종양을 주증으로 내원하였다. 신체검사상 오른쪽 상악 잇몸에서 돌출된 구강내 종양이 관찰되었다. 내원당시 전이소견은 관찰되지 않았으며 구강 종양의 절제생검을 통한 조직검사결과 전반적인 상피양 세포와 일부 방추세포를 가진 전형적인 신경내분비종으로 의심되는 소견이 관찰되었다. 멜라닌 과립으로 추정되는 소견은 관찰되지 않았지만 악성종양에서 관찰되는 세포의 유사분열은 다수 관찰되었다. 확진을 위해 조직 절제 단면에 Melan A를 이용한 면역화학조직 염색을 실시하였으며, 그 결과는 강한 양성반응을 나타내었다. 조직검사와 조직면역염색을 통하여 종양은 멜라닌 결핍 악성흑색종으로 진단되었다. 결론적으로 본 증례의 경우 개에서 멜라닌결핍 악성흑색종의 진단에 Melan A를 이용한 면역화학조직염색이 유용함을 보여준다고 생각된다.

Keywords

References

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