Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Screening of Antioxidative, Anti-thrombotic and Anti-atherosclerotic Effects of Moutan Root Bark Extracts

Moutan Root Bark가 항산화활성과 LDL 산화 억제 및 항철소판 응접에 미치는 영향

  • Ban, Chang-Kye (Cardiovascular Medical Research Center and Department of Diagnostics, College of Oriental Medicine, Dongguk University) ;
  • Lee, Min-Ja (Cardiovascular Medical Research Center and Department of Diagnostics, College of Oriental Medicine, Dongguk University) ;
  • Lee, Hye-Sook (Cardiovascular Medical Research Center and Department of Diagnostics, College of Oriental Medicine, Dongguk University) ;
  • Jung, Hyun-Jung (Cardiovascular Medical Research Center and Department of Diagnostics, College of Oriental Medicine, Dongguk University) ;
  • Kim, Hyuck (Cardiovascular Medical Research Center and Department of Diagnostics, College of Oriental Medicine, Dongguk University) ;
  • Kim, Jai-Eun (Cardiovascular Medical Research Center and Department of Pathology, College of Oriental Medicine, Dongguk University) ;
  • Park, Sun-Dong (Cardiovascular Medical Research Center and Department of Prescriptionology, College of Oriental Medicine, Dongguk University) ;
  • Park, Won-Hwan (Cardiovascular Medical Research Center and Department of Diagnostics, College of Oriental Medicine, Dongguk University)
  • 반창규 (동국대학교 한의과대학 기초의과학연구센터 & 진단학교실) ;
  • 이민자 (동국대학교 한의과대학 기초의과학연구센터 & 진단학교실) ;
  • 이혜숙 (동국대학교 한의과대학 기초의과학연구센터 & 진단학교실) ;
  • 정현정 (동국대학교 한의과대학 기초의과학연구센터 & 진단학교실) ;
  • 김혁 (동국대학교 한의과대학 기초의과학연구센터 & 진단학교실) ;
  • 김재은 (동국대학교 한의과대학 기초의과학연구센터 & 병리학교실) ;
  • 박선동 (동국대학교 한의과대학 기초의과학연구센터 & 방제학교실) ;
  • 박원환 (동국대학교 한의과대학 기초의과학연구센터 & 진단학교실)
  • Published : 2009.02.25
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Abstract

There is currently increased interest in the identification of antioxidant compounds that are pharmacologically potent and have low or no side effects. Plants produce significant amounts of antioxidants to prevent the oxidative stress caused by photons and oxygen, therefore they represent a potential source of new compounds with antioxidant activity. Moutan Root Sark (MRS) has been frequently used as analgesic. antispasmodic, anti-inflammatory and remedies for female diseases. In this study. the antioxidant activity of extract from MRS was studied in vitro methods by measuring the antioxidant activity by TEAC, measuring the scavenging effects on reactive oxygen species (ROS) [superoxide anion, hydroxyl radical] and on reactive nitrogen species (RNS) [nitric oxide and peroxynitrite] as well as measuring the inhibitory effect on $Cu^{2+}$ induced human LDL oxidation and the inhibitory effect on collagen induced platelet aggregation. The MRS extracts were found to have a potent scavenging activity, as well as an inhibitory effect on LDL oxidation and on platelet aggregation. In conclusion, the MRS extracts have anti-oxidative and anti-atherosclerotic effects in vitro system, which can be used for developing pharmaceutical drug against oxidative stress and atherosclerosis.

Keywords

References

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