Clinical and Experimental Pediatrics

대한소아청소년과학회 (The Korean Pediatric Society)
권호 표지
DOI QR코드

DOI QR Code

소아 신이식의 최신 지견

Current status of pediatric kidney transplantation

  • 김성도 (경희대학교 의과대학 소아과학교실) ;
  • 조병수 (경희대학교 의과대학 소아과학교실)
  • Kim, Sung-Do (Department of Pediatrics, School of Medicine, Kyung Hee University) ;
  • Cho, Byoung-Soo (Department of Pediatrics, School of Medicine, Kyung Hee University)
  • 투고 : 2009.09.04
  • 심사 : 2009.11.20
  • 발행 : 2009.10.15
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Renal transplantation is the treatment of choice for children with end-stage renal disease. The outcome of pediatric kidney transplantation has improved dramatically in recent years, with lower acute rejection rates, superior graft survival, and low mortality. These improvements have allowed increased attention to other aspects of care for long-term survivors. Taking this into consideration, this review article will focus on the key issues related to pediatric kidney transplantation such as growth, neurocognitive function, nonadherence, and posttransplantation infectious complications, including lymphoproliferative disease, to broaden the understanding of pediatricians who provide pre-and postoperative care to children with end-stage renal disease.

키워드

참고문헌

  1. Goldstein SL, Graham N, Burwinkle T, Warady B, Farrah R, Varni JW. Health-related quality of life in pediatric patients with ESRD. Pediatr Nephrol 2006;21:846-50 https://doi.org/10.1007/s00467-006-0081-y
  2. Torkaman M, Khalili-Matin-Zadeh Z, Azizabadi-Farahani M, Moghani-Lankarani M, Assari S, Pourfarziani V, et al. Outcome of living kidney transplant: Pediatric in comparison to adults. Transplant Proc 2007;39:1088-90 https://doi.org/10.1016/j.transproceed.2007.03.090
  3. Smith JM, Stablein DM, Munoz R, Hebert D, McDonald RA. Contributions of the transplant registry: The 2006 annual report of the north american pediatric renal trials and collaborative studies (NAPRTCS). Pediatr Transplant 2007;11:366-73 https://doi.org/10.1111/j.1399-3046.2007.00704.x
  4. Kim PK. Renal transplantation in korean children: cooperative study. J Korean Soc Transplant 1997;11:217-24
  5. Kim KH, Yae SJ, Kim JS, Kwon TG, Chung SK. Clinical Experience of 27 Pediatric Renal Transplantation at a Single Center. Korean J Urol 2007;48:72-6 https://doi.org/10.4111/kju.2007.48.1.72
  6. Kim SJ, Jung IM, Jung SE, Kim MY, Lee TS, Ha JW, et al. Experience with 129 Pediatric (<21 yr) Kidney Transplantations. J Korean Surg Soc 1999;56:886-97
  7. Lee SY, Han H, Park YS, Han DJ. Clinical Experience of 60 Pediatric Renal Transplantations at a Single Center. Korean J Pediatr 2004;47:55-65
  8. Scandling JD. Kidney transplant candidate evaluation. Semin Dial 2005;18:487-94 https://doi.org/10.1111/j.1525-139X.2005.00094.x
  9. Cochat P, Fargue S, Mestrallet G, Jungraithmayr T, Koch- Nogueira P, Ranchin B, et al. Disease recurrence in paediatric renal transplantation. Pediatr Nephrol 2009;24:2097-108 https://doi.org/10.1007/s00467-009-1137-6
  10. Pourfarziani V, Ramezani MB, Taheri S, Izadi M, Einollahi B. Immunogenicity of pneumococcal vaccination in renal transplant recipients and hemodialysis patients: A comparative controlled trial. Ann Transplant 2008;13:43-7
  11. Watkins SL, Alexander SR, Brewer ED, Hesley TM, West DJ, Chan IS, et al. Response to recombinant hepatitis B vaccine in children and adolescents with chronic renal failure. Am J Kidney Dis 2002;40:365-72 https://doi.org/10.1053/ajkd.2002.34521
  12. Neuhaus TJ. Immunization in children with chronic renal failure: A practical approach. Pediatr Nephrol 2004;19:1334-9 https://doi.org/10.1007/s00467-004-1597-7
  13. Neu AM, Fivush BA. Recommended immunization practices for pediatric renal transplant recipients. Pediatr Transplant 1998;2:263-9
  14. Barril G, Teruel JL. Vaccination scheme in advanced chronic kidney disease. Nefrologia 2008;28 Suppl 3:95-9
  15. Alam S, Sheldon C. Urological issues in pediatric renal transplantation. Curr Opin Urol 2008;18:413-8 https://doi.org/10.1097/MOU.0b013e328302ede7
  16. Rigamonti W, Capizzi A, Zacchello G, Capizzi V, Zanon GF, Montini G, et al. Kidney transplantation into bladder augmentation or urinary diversion: Long-term results. Transplantation 2005;80:1435-40 https://doi.org/10.1097/01.tp.0000174342.19265.f4
  17. Shoma AM, Eraky I, El-Kappany HA. Pretransplant native nephrectomy in patients with end-stage renal failure: Assessment of the role of laparoscopy. Urology 2003;61:915-20 https://doi.org/10.1016/S0090-4295(02)02556-6
  18. Li C, Yang CW. The pathogenesis and treatment of chronic allograft nephropathy. Nat Rev Nephrol 2009;5:513-9 https://doi.org/10.1038/nrneph.2009.113
  19. Sezer S, Ozdemir FN, Agca E, Colak T, Arat Z, Haberal M. Assessment of risk factors for chronic allograft nephropathy in renal transplant patients. Transplant Proc 2003;35:2634-6 https://doi.org/10.1016/j.transproceed.2003.08.046
  20. Tonshoff B, Hocker B. Treatment strategies in pediatric solid organ transplant recipients with calcineurin inhibitor-induced nephrotoxicity. Pediatr Transplant 2006;10:721-9 https://doi.org/10.1111/j.1399-3046.2006.00577.x
  21. McGraw ME, Haka-Ikse K. Neurologic-developmental sequelae of chronic renal failure in infancy. J Pediatr 1985;106: 579-83 https://doi.org/10.1016/S0022-3476(85)80075-5
  22. Rotundo A, Nevins TE, Lipton M, Lockman LA, Mauer SM, Michael AF. Progressive encephalopathy in children with chronic renal insufficiency in infancy. Kidney Int 1982;21: 486-91 https://doi.org/10.1038/ki.1982.50
  23. Elzouki A, Carroll J, Butinar D, Moosa A. Improved neurological outcome in children with chronic renal disease from infancy. Pediatr Nephrol 1994;8:205-10 https://doi.org/10.1007/BF00865479
  24. Qvist E, Jalanko H, Holmberg C. Psychosocial adaptation after solid organ transplantation in children. Pediatr Clin North Am 2003;50:1505-19 https://doi.org/10.1016/S0031-3955(03)00128-7
  25. Brouhard BH, Donaldson LA, Lawry KW, McGowan KR, Drotar D, Davis I, et al. Cognitive functioning in children on dialysis and post-transplantation. Pediatr Transplant 2000;4: 261-7 https://doi.org/10.1034/j.1399-3046.2000.00121.x
  26. Chavers BM, Solid CA, Gilbertson DT, Collins AJ. Infection- related hospitalization rates in pediatric versus adult patients with end-stage renal disease in the united states. J Am Soc Nephrol 2007;18:952-9 https://doi.org/10.1681/ASN.2006040406
  27. Dharnidharka VR, Harmon WE. Management of pediatric postrenal transplantation infections. Semin Nephrol 2001;21: 521-31 https://doi.org/10.1053/snep.2001.24947
  28. Neu AM. Special issues in pediatric kidney transplantation. Adv Chronic Kidney Dis 2006;13:62-9 https://doi.org/10.1053/j.ackd.2005.10.001
  29. Succi RC, Farhat CK. Vaccination in special situations. J Pediatr (Rio J) 2006;82:S91-100 https://doi.org/10.2223/JPED.1474
  30. Bouts AH, Davin JC, Krediet RT, van der Weel MB, Schroder CH, Monnens L, et al. Immunoglobulins in chronic renal failure of childhood: Effects of dialysis modalities. Kidney Int 2000;58:629-37 https://doi.org/10.1046/j.1523-1755.2000.00209.x
  31. Dharnidharka VR, Araya CE. Post-transplant lymphoproliferative disease. Pediatr Nephrol 2009;24:731-6 https://doi.org/10.1007/s00467-007-0582-3
  32. Baluarte HJ, Gruskin AB, Ingelfinger JR, Stablein D, Tejani A. Analysis of hypertension in children post renal transplantation --a report of the north american pediatric renal transplant cooperative study (NAPRTCS). Pediatr Nephrol 1994;8:570- 3 https://doi.org/10.1007/BF00858130
  33. Mitsnefes MM, Khoury PR, McEnery PT. Early posttransplantation hypertension and poor long-term renal allograft survival in pediatric patients. J Pediatr 2003;143:98-103 https://doi.org/10.1016/S0022-3476(03)00209-9
  34. Raiss Jalali GA, Fazelzadeh A, Mehdizadeh AR. Effect of hypertension on transplant kidney function: Three year of follow-up. Transplant Proc 2007;39:941-2 https://doi.org/10.1016/j.transproceed.2007.03.057
  35. Ahmed K, Michael B, Burke JF,Jr. Effects of isradipine on renal hemodynamics in renal transplant patients treated with cyclosporine. Clin Nephrol 1997;48:307-10
  36. Premasathian NC, Muehrer R, Brazy PC, Pirsch JD, Becker BN. Blood pressure control in kidney transplantation: Therapeutic implications. J Hum Hypertens 2004;18:871-7 https://doi.org/10.1038/sj.jhh.1001767
  37. Baum MA. Outcomes after renal transplantation for FSGS in children. Pediatr Transplant 2004;8:329-33 https://doi.org/10.1111/j.1399-3046.2004.00181.x
  38. Fine RN. Recurrence of nephrotic syndrome/focal segmental glomerulosclerosis following renal transplantation in children. Pediatr Nephrol 2007;22:496-502 https://doi.org/10.1007/s00467-006-0361-6
  39. Hickson LJ, Gera M, Amer H, Iqbal CW, Moore TB, Milliner DS, et al. Kidney transplantation for primary focal segmental glomerulosclerosis: Outcomes and response to therapy for recurrence. Transplantation 2009;87:1232-9 https://doi.org/10.1097/TP.0b013e31819f12be
  40. Mehls O, Ritz E. Skeletal growth in experimental uremia. Kidney Int Suppl 1983;15:S53-62
  41. Seikaly MG, Salhab N, Gipson D, Yiu V, Stablein D. Stature in children with chronic kidney disease: Analysis of NAPRTCS database. Pediatr Nephrol 2006;21:793-9 https://doi.org/10.1007/s00467-006-0040-7
  42. Nissel R, Brazda I, Feneberg R, Wigger M, Greiner C, Querfeld U, et al. Effect of renal transplantation in childhood on longitudinal growth and adult height. Kidney Int 2004;66: 792-800 https://doi.org/10.1111/j.1523-1755.2004.00805.x
  43. Fine RN, Ho M, Tejani A, North American Pediatric Renal Trasplant Cooperative Study (NAPRTCS). The contribution of renal transplantation to final adult height: A report of the north american pediatric renal transplant cooperative study (NAPRTCS). Pediatr Nephrol 2001;16:951-6 https://doi.org/10.1007/s004670100002
  44. Fine RN. Management of growth retardation in pediatric recipients of renal allografts. Nat Clin Pract Nephrol 2007;3: 318-24 https://doi.org/10.1038/ncpneph0502
  45. Fine RN, Stablein D. Long-term use of recombinant human growth hormone in pediatric allograft recipients: A report of the NAPRTCS transplant registry. Pediatr Nephrol 2005;20: 404-8 https://doi.org/10.1007/s00467-004-1688-5
  46. Guest G, Berard E, Crosnier H, Chevallier T, Rappaport R, Broyer M. Effects of growth hormone in short children after renal transplantation. french society of pediatric nephrology. Pediatr Nephrol 1998;12:437-4 https://doi.org/10.1007/s004670050483
  47. Benfield MR. Current status of kidney transplant: Update 2003. Pediatr Clin North Am 2003;50:1301-34 https://doi.org/10.1016/S0031-3955(03)00122-6
  48. Dobbels F, Van Damme-Lombaert R, Vanhaecke J, De Geest S. Growing pains: Non-adherence with the immunosuppressive regimen in adolescent transplant recipients. Pediatr Transplant 2005;9:381-90 https://doi.org/10.1111/j.1399-3046.2005.00356.x
  49. Gaston RS, Hudson SL, Ward M, Jones P, Macon R. Late renal allograft loss: Noncompliance masquerading as chronic rejection. Transplant Proc 1999;31:21S-3S

피인용 문헌

  1. Severe Anemia Due to Parvovirus Infection Following Treatment with Rituximab in a Pediatric Kidney Transplant Recipient : Anemia after Treatment of Rituximab in Kidney Recipient Patient vol.19, pp.2, 2009, https://doi.org/10.3339/chikd.2015.19.2.176
  2. Experience with Pediatric Kidney Transplantation, 1985-2016: A Single Regional Center Study vol.21, pp.2, 2017, https://doi.org/10.3339/jkspn.2017.21.2.69