Clinical and Experimental Pediatrics

The Korean Pediatric Society (대한소아청소년과학회)
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Correlaton between soluble transferrin receptor concentration and inflammatory markers

수용성 트랜스페린 수용체의 농도와 염증 인자와의 관련성에 관한 연구

  • Kim, So Young (Department of Pediatrics, Gyeongsang National University School of Medicine) ;
  • Son, Meong Hi (Department of Pediatrics, Gyeongsang National University School of Medicine) ;
  • Yeom, Jung suk (Department of Pediatrics, Gyeongsang National University School of Medicine) ;
  • Park, Ji sook (Department of Pediatrics, Gyeongsang National University School of Medicine) ;
  • Park, Eun Sil (Department of Pediatrics, Gyeongsang National University School of Medicine) ;
  • Seo, Ji-Hyun (Department of Pediatrics, Gyeongsang National University School of Medicine) ;
  • Lim, Jae-Young (Department of Pediatrics, Gyeongsang National University School of Medicine) ;
  • Park, Chan-Hoo (Department of Pediatrics, Gyeongsang National University School of Medicine) ;
  • Woo, Hyang-Ok (Department of Pediatrics, Gyeongsang National University School of Medicine) ;
  • Youn, Hee-Shang (Department of Pediatrics, Gyeongsang National University School of Medicine)
  • 김소영 (경상대학교 의학전문대학원 소아과학교실) ;
  • 손명희 (경상대학교 의학전문대학원 소아과학교실) ;
  • 염정숙 (경상대학교 의학전문대학원 소아과학교실) ;
  • 박지숙 (경상대학교 의학전문대학원 소아과학교실) ;
  • 박은실 (경상대학교 의학전문대학원 소아과학교실) ;
  • 서지현 (경상대학교 의학전문대학원 소아과학교실) ;
  • 임재영 (경상대학교 의학전문대학원 소아과학교실) ;
  • 박찬후 (경상대학교 의학전문대학원 소아과학교실) ;
  • 우향옥 (경상대학교 의학전문대학원 소아과학교실) ;
  • 윤희상 (경상대학교 의학전문대학원 소아과학교실)
  • Received : 2008.09.12
  • Accepted : 2008.12.01
  • Published : 2009.04.15
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Abstract

Purpose : The concentration of soluble transferrin receptor (sTfR) is estimated as an iron parameter to evaluate erythropoiesis and iron status. The aim of our study is to evaluate the correlation between sTfR concentration and inflammatory parameters and to distinguish iron deficiency anemia from anemia of inflammation. Methods : One hundred and forty-four infants younger than two years of age who visited Gyeongsang University Hospital for 7 years from 2000 to 2006 were enrolled. Patients who had hemoglobin (Hb) <11 g/dL and ferritin <12 mg/L were excluded. Routine hematologic lab, serum ferritin, sTfR, and inflammatory markers [C-reactive protein(CRP), interleukin-6(IL-6), and absolute neutrophil count (ANC)] were investigated. Results : In all patients, the sTfR concentration showed a correlation with Hb, ferritin, MCV, and ANC, but not with CRP and IL-6. In multiple regression models, positive correlations were found between sTfR concentration and IL-6 (r=0.078, P=0.043), and negative correlations were found between sTfR concentration and ANC (r=-0.117, P=0.033) and MCV (r=-0.027, P=0.009). Conclusion : sTfR concentration was influenced by inflammatory parameters. Therefore, sTfR does not appear to be a useful parameter for discriminating between iron deficiency anemia and anemia of inflammation in infants.

서 론 : 수용성 트랜스페린 수용체(sTfR)는 적혈구 조혈 및 철분 상태를 나타내는 지표로 이용된다. 본 연구는 급성 염증물질과 sTfR 농도와의 관계를 밝히고, 철분 부족 상태와 염증으로 인한 빈혈을 감별하는데 sTfR 농도가 유용한지를 알아보고자 한다. 방 법 : 2000년 1월부터 2006년 6월까지 경상대학교 병원 소아청소년과를 내원한 2세 미만의 영유아 144명을 대상으로 이들의 Hb, MCV, 페리틴, 수용성 트랜스페린 수용체, 염증인자[CRP, IL-6, ANC]를 측정하였다. Hb 11 g/dL 미만이고 페리틴 12 ug/L 미만인 철결핍 빈혈 환아는 조사에서 제외하였다. 결 과 : 전체 환자군에서 sTfR 농도는 Hb, 페리틴, MCV, ANC와 유의한 음의 상관관계를 보였고 CRP, IL-6 와는 상관관계를 보이지 않았다. 다중 선형 회귀 분석 시 IL-6 (r=0.078, P=0.043)는 sTfR 농도와 양의 상관관계를 보였고, ANC (r=-0.117, P=0.033), MCV (r=-0.027, P=0.009)는 음의 상관관계를 보였다. 결 론 : 영유아에서 sTfR 농도는 염증 상태에 따라 영향을 받을 수 있으므로 급성 감염에 의한 빈혈과 철결핍성 빈혈의 감별진단을 위해서 sTfR 농도를 단독으로 사용하는데 제한점이 있다.

Keywords

References

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