Correlation Between the Osmolar Gap and Serum Ethanol Level and the Accuracy of Estimated Ethanol Level in Trauma Patients and Non-Trauma Patients

외상 환자와 비외상 환자에서 삼투압차와 에탄올 농도의 상관관계 및 추정 에탄올 농도의 정확도

  • Chang, Hyung Woo (Department of Emergency Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Sim, Min Seob (Department of Emergency Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Han, Sang Kuk (Department of Emergency Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine) ;
  • Song, Hyoung Gon (Department of Emergency Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine)
  • 장형우 (성균관대학교 의과대학 삼성서울병원 응급의학과) ;
  • 심민섭 (성균관대학교 의과대학 삼성서울병원 응급의학과) ;
  • 한상국 (성균관대학교 의과대학 강북삼성병원 응급의학과) ;
  • 송형곤 (성균관대학교 의과대학 삼성서울병원 응급의학과)
  • Received : 2009.07.22
  • Accepted : 2009.10.20
  • Published : 2009.12.30

Abstract

Purpose: The osmolar gap increases in proportion to the ethanol level. Some previous studies have shown that the correlation between the osmolar gap and the ethanol level is weak in trauma patient by using an indirect comparison with other patients. We conducted a direct comparison of the correlation of the osmolar gap to the ethanol level between trauma patients and non-trauma patients. We also analyzed the accuracy of the estimated ethanol level between the two groups. Methods: The research candidates were adult patients who had visited the emergency department of our hospital from December 2003 to November 2008. By using a retrospective chart review, we classified them into three subgroups: non-trauma without shock, trauma without shock, and trauma with shock. In each group, we compared the correlation between the osmolar gap and the measured ethanol level, and we analyzed the accuracy of the estimated ethanol level by using Lin's concordance correlation coefficient. Results: Four hundred forty-seven patients were enrolled in this study. For correlation of the osmolar gap and the measured ethanol level, Pearson's correlation coefficient was 0.916 in all patients, 0.939 in non-trauma without shock patients, 0.917 in trauma without shock patients, and 0.844 in trauma with shock patients. In the analysis of the accuracy of the estimated ethanol level by using Lin's concordance correlation coefficient, the accuracy in trauma with shock patients was lower than that in non-trauma without shock patients. Conclusion: We found that the correlation between the osmolar gap and the measured ethanol level in the patient group with trauma was lower than it was in the patient group without trauma. Moreover trauma patients with shock had a lower accuracy of the estimated ethanol level than non-trauma patients.

Keywords

References

  1. Etherington JM. Emergency management of acute alcohol problems. Part 1: Uncomplicated withdrawal. Can Fam Physician 1996;42:2186-90
  2. Pletcher MJ, Maselli J, Gonzales R. Uncomplicated alcohol intoxication in the emergency department: an analysis of the National Hospital Ambulatory Medical Care Survey. Am J Med 2004;117:863-7 https://doi.org/10.1016/j.amjmed.2004.07.042
  3. Maier RV. Ethanol abuse and the trauma patient. Surg Infect (Larchmt) 2001;2:133-41; discussion 41-4 https://doi.org/10.1089/109629601750469456
  4. Cherpitel CJ, Bond J, Ye Y, Borges G, MacDonald S, Stockwell T, et al. Alcohol-related injury in the ER: a cross-national meta-analysis from the Emergency Room Collaborative Alcohol Analysis Project (ERCAAP). J Stud Alcohol 2003;64:641-9 https://doi.org/10.15288/jsa.2003.64.641
  5. Zink BJ, Stern SA, McBeth BD, Wang X, Mertz M. Effects of ethanol on limited resuscitation in a model of traumatic brain injury and hemorrhagic shock. J Neurosurg 2006;105:884-93 https://doi.org/10.3171/jns.2006.105.6.884
  6. Lee K. Trend of alcohol involvement in maxillofacial trauma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2009;107:e9-13 https://doi.org/10.1016/j.tripleo.2008.12.020
  7. Shandro JR, Rivara FP, Wang J, Jurkovich GJ, Nathens AB, MacKenzie EJ. Alcohol and risk of mortality in patients with traumatic brain injury. J Trauma 2009;66:1584-90 https://doi.org/10.1097/TA.0b013e318182af96
  8. Sayette MA, Martin CS, Perrott MA. Effects of assessment frequency on subjective intoxication ratings after alcohol consumption. Alcohol Clin Exp Res 2001;25:844-6 https://doi.org/10.1111/j.1530-0277.2001.tb02288.x
  9. Cherpitel CJ, Ye Y, Bond J, Borges G, Macdonald S, Stockwell T, et al. Validity of self-reported drinking before injury compared with a physiological measure: cross-national analysis of emergency-department data from 16 countries. J Stud Alcohol Drugs 2007;68:296-302 https://doi.org/10.15288/jsad.2007.68.296
  10. Purssell RA, Lynd LD, Koga Y. The use of the osmole gap as a screening test for the presence of exogenous substances. Toxicol Rev 2004;23:189-202 https://doi.org/10.2165/00139709-200423030-00005
  11. Lynd LD, Richardson KJ, Purssell RA, Abu-Laban RB, Brubacher JR, Lepik KJ, et al. An evaluation of the osmole gap as a screening test for toxic alcohol poisoning. BMC Emerg Med 2008;8:5 https://doi.org/10.1186/1471-227X-8-5
  12. Li G, Keyl PM, Rothman R, Chanmugam A, Kelen GD. Epidemiology of alcohol-related emergency department visits. Acad Emerg Med 1998;5:788-95 https://doi.org/10.1111/j.1553-2712.1998.tb02505.x
  13. Purssell RA, Pudek M, Brubacher J, Abu-Laban RB. Derivation and validation of a formula to calculate the contribution of ethanol to the osmolal gap. Ann Emerg Med 2001;38:653-9 https://doi.org/10.1067/mem.2001.119455
  14. Galvan LA, Watts MT. Generation of an osmolality gap-ethanol nomogram from routine laboratory data. Ann Emerg Med 1992;21:1343-8 https://doi.org/10.1016/S0196-0644(05)81899-2
  15. Osterloh JD, Kelly TJ, Khayam-Bashi H, Romeo R. Discrepancies in osmolal gaps and calculated alcohol concentrations. Arch Pathol Lab Med 1996;120:637-41
  16. Britten JS, Myers RA, Benner C, Carson S, Cowley RA. Blood ethanol and serum osmolality in the trauma patient. Am Surg 1982;48:451-5
  17. Champion HR, Sacco WJ, Copes WS, Gann DS, Gennarelli TA, Flanagan ME. A revision of the Trauma Score. J Trauma 1989;29:623-9 https://doi.org/10.1097/00005373-198905000-00017
  18. Rasouli M, Kalantari KR. Comparison of methods for calculating serum osmolality: multivariate linear regression analysis. Clin Chem Lab Med 2005;43:635-40 https://doi.org/10.1515/CCLM.2005.109
  19. Worthley LI, Guerin M, Pain RW. For calculating osmolality, the simplest formula is the best. Anaesth Intensive Care 1987;15:199-202
  20. Lin L, Torbeck LD. Coefficient of accuracy and concordance correlation coefficient: new statistics for methods comparison. PDA J Pharm Sci Technol 1998;52:55-9
  21. Lin LI. A concordance correlation coefficient to evaluate reproducibility. Biometrics 1989;45:255-68 https://doi.org/10.2307/2532051
  22. Hoffman RS, Smilkstein MJ, Howland MA, Goldfrank LR. Osmol gaps revisited: normal values and limitations. J Toxicol Clin Toxicol 1993;31:81-93 https://doi.org/10.3109/15563659309000375
  23. Pappas AA, Gadsden RH, Sr., Taylor EH. Serum osmolality in acute intoxication: a prospective clinical study. Am J Clin Pathol 1985;84:74-9 https://doi.org/10.1093/ajcp/84.1.74
  24. Broder G, Weil MH. Excess Lactate: An Index of Reversibility of Shock in Human Patients. Science 1964;143:1457-9 https://doi.org/10.1126/science.143.3613.1457
  25. Peretz DI, Scott HM, Duff J, Dossetor JB, MacLean LD, McGregor M. The significance of lacticacidemia in the shock syndrome. Ann N Y Acad Sci 1965;119:1133-41 https://doi.org/10.1111/j.1749-6632.1965.tb47467.x
  26. Singh CM, Flear CT. Experimental haemorrhagic and endotoxic shock in dogs: evidence for imbalance in exchanges of water and solutes across cell membrane. Br J Surg 1969;56:703
  27. Sklar AH, Linas SL. The osmolal gap in renal failure. Ann Intern Med 1983;98:481-2 https://doi.org/10.7326/0003-4819-98-4-481
  28. Inaba H, Hirasawa H, Mizuguchi T. Serum osmolality gap in postoperative patients in intensive care. Lancet 1987;1:1331-5
  29. Milionis HJ, Liamis GL, Elisaf MS. The hyponatremic patient: a systematic approach to laboratory diagnosis. CMAJ 2002;166:1056-62